Oxytocin pathway gene networks in the human brain
Quintana DS, Rokicki J, van der Meer D, Alnæs D, Kaufmann T, Córdova-Palomera A, Dieset I, Andreassen OA, Westlye LT. · Nature Communications · 2019 · Human post-mortem expression mapping and co-expression analysis
Original publication · Original publication · Original publication
Recorded summary
Human brain expression maps showed regional enrichment of oxytocin-pathway transcripts and co-expression with dopaminergic and muscarinic acetylcholine genes. The study provides anatomical context for an OXTR-centred research programme.
Attributed extracts from the research record
“Three oxytocin signaling genes have been frequently implicated in human social behavior: OXT (structural gene for oxytocin), OXTR (oxytocin receptor), and CD38 (oxytocin secretion).”
“Expression of the three selected oxytocin pathway genes was enriched in subcortical and olfactory regions and there was high co-expression with several dopaminergic and muscarinic acetylcholine genes, reflecting an anatomical basis for critical gene pathway interactions.”
“The oxytocin signaling system may interact with dopaminergic and muscarinic acetylcholine signaling to modulate cognitive state processes involved in complex human behaviors.”
Recorded limitations
Spatial co-expression is an association. This study did not test sound, vision or language interventions, Fibonacci-derived features, or causal interactions across the proposed target network.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Human post-mortem expression mapping and co-expression analysis
- assessment
- Not recorded
- trust Factor
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/30737392/ · https://doi.org/10.1038/s41467-019-08503-8 · https://www.nature.com/articles/s41467-019-08503-8
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- Not recorded
Topics and recorded topic scores
- key
- sound:xxix
- title
- Oxytocin pathways, dopamine and serotonin
- collection
- sound
- trust Score
- 1
- key
- general:sound-xxix
- title
- Oxytocin pathways, dopamine and serotonin
- collection
- general
- trust Score
- 1
Citation snapshot and identifiers
- id
- pmid-30737392
- doi
- 10.1038/s41467-019-08503-8
- pmid
- 30737392
- citation Snapshot
- Not recorded
- citations By Collection
- sound
- 76
- vision
- Not recorded
- language
- Not recorded
- general
- 76
Complete approved library record
- id
- pmid-30737392
- publication Key
- Not recorded
- aliases
- None recorded
- title
- Oxytocin pathway gene networks in the human brain
- journal
- Nature Communications
- publisher Family
- nature
- publisher Family Label
- Nature Portfolio
- neurotransmitters
- None recorded
- year
- 2019
- authors
- Quintana DS, Rokicki J, van der Meer D, Alnæs D, Kaufmann T, Córdova-Palomera A, Dieset I, Andreassen OA, Westlye LT.
- design
- Human post-mortem expression mapping and co-expression analysis
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1038/s41467-019-08503-8
- pmid
- 30737392
- urls
https://www.nature.com/articles/s41467-019-08503-8 · https://doi.org/10.1038/s41467-019-08503-8 · https://pmc.ncbi.nlm.nih.gov/articles/PMC6368605/
- collections
sound · vision · language · general
- categories
Gene expression · Methods & context
- targets
OXTR · OXT · CD38 · DRD2
- priority
- 0
- quotes
“Three oxytocin signaling genes have been frequently implicated in human social behavior: OXT (structural gene for oxytocin), OXTR (oxytocin receptor), and CD38 (oxytocin secretion).” · “Expression of the three selected oxytocin pathway genes was enriched in subcortical and olfactory regions and there was high co-expression with several dopaminergic and muscarinic acetylcholine genes, reflecting an anatomical basis for critical gene pathway interactions.” · “The oxytocin signaling system may interact with dopaminergic and muscarinic acetylcholine signaling to modulate cognitive state processes involved in complex human behaviors.”
- summary
- Human brain expression maps showed regional enrichment of oxytocin-pathway transcripts and co-expression with dopaminergic and muscarinic acetylcholine genes. The study provides anatomical context for an OXTR-centred research programme.
- limitation
- Spatial co-expression is an association. This study did not test sound, vision or language interventions, Fibonacci-derived features, or causal interactions across the proposed target network.
- citation Count
- 76
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/30737392/ · https://doi.org/10.1038/s41467-019-08503-8 · https://www.nature.com/articles/s41467-019-08503-8
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- sound
- 76
- vision
- Not recorded
- language
- Not recorded
- general
- 76
- topics
- key
- sound:xxix
- title
- Oxytocin pathways, dopamine and serotonin
- collection
- sound
- trust Score
- 1
- key
- general:sound-xxix
- title
- Oxytocin pathways, dopamine and serotonin
- collection
- general
- trust Score
- 1
- journal Key
- naturecommunications
- journal Label
- Nature Communications
- chapter Entries
- id
- xxix-pmid-30737392
- record Id
- pmid-30737392
- title
- Oxytocin pathway gene networks in the human brain
- journal
- Nature Communications
- year
- 2019
- authors
- Quintana DS, Rokicki J, van der Meer D, Alnæs D, Kaufmann T, Córdova-Palomera A, Dieset I, Andreassen OA, Westlye LT.
- design
- urls
https://www.nature.com/articles/s41467-019-08503-8 · https://doi.org/10.1038/s41467-019-08503-8 · https://pmc.ncbi.nlm.nih.gov/articles/PMC6368605/
- quotes
- text
- “Three oxytocin signaling genes have been frequently implicated in human social behavior: OXT (structural gene for oxytocin), OXTR (oxytocin receptor), and CD38 (oxytocin secretion).”
- emphasis
- false
- text
- “Expression of the three selected oxytocin pathway genes was enriched in subcortical and olfactory regions and there was high co-expression with several dopaminergic and muscarinic acetylcholine genes, reflecting an anatomical basis for critical gene pathway interactions.”
- emphasis
- false
- text
- “The oxytocin signaling system may interact with dopaminergic and muscarinic acetylcholine signaling to modulate cognitive state processes involved in complex human behaviors.”
- emphasis
- false
- citation Count
- 76
- source Pages
119
- targets
OXTR · OXT · CD38 · DRD2
- categories
Gene expression · Methods & context
- doi
- 10.1038/s41467-019-08503-8
- pmid
- 30737392
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/30737392/ · https://doi.org/10.1038/s41467-019-08503-8 · https://www.nature.com/articles/s41467-019-08503-8
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- collection
- sound
- chapter Number
- 6
- topic Id
- xxix
- topic Title
- Oxytocin pathways, dopamine and serotonin
- trust Score
- 1
- id
- general-xxix-pmid-30737392
- record Id
- pmid-30737392
- title
- Oxytocin pathway gene networks in the human brain
- journal
- Nature Communications
- year
- 2019
- authors
- Quintana DS, Rokicki J, van der Meer D, Alnæs D, Kaufmann T, Córdova-Palomera A, Dieset I, Andreassen OA, Westlye LT.
- design
- urls
https://www.nature.com/articles/s41467-019-08503-8 · https://doi.org/10.1038/s41467-019-08503-8 · https://pmc.ncbi.nlm.nih.gov/articles/PMC6368605/
- quotes
- text
- “Three oxytocin signaling genes have been frequently implicated in human social behavior: OXT (structural gene for oxytocin), OXTR (oxytocin receptor), and CD38 (oxytocin secretion).”
- emphasis
- false
- text
- “Expression of the three selected oxytocin pathway genes was enriched in subcortical and olfactory regions and there was high co-expression with several dopaminergic and muscarinic acetylcholine genes, reflecting an anatomical basis for critical gene pathway interactions.”
- emphasis
- false
- text
- “The oxytocin signaling system may interact with dopaminergic and muscarinic acetylcholine signaling to modulate cognitive state processes involved in complex human behaviors.”
- emphasis
- false
- citation Count
- 76
- source Pages
119
- targets
OXTR · OXT · CD38 · DRD2
- categories
Gene expression · Methods & context
- doi
- 10.1038/s41467-019-08503-8
- pmid
- 30737392
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/30737392/ · https://doi.org/10.1038/s41467-019-08503-8 · https://www.nature.com/articles/s41467-019-08503-8
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- collection
- general
- chapter Number
- 1
- topic Id
- sound-xxix
- topic Title
- Oxytocin pathways, dopamine and serotonin
- trust Score
- 1
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
1
- full Text
- status
- open-license
- retrieval Available
- true
- url
- https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6368605/fullTextXML
- pmcid
- PMC6368605
- rights
- license
- http://creativecommons.org/licenses/by/4.0/
- statement
© The Author(s) 2019 https://creativecommons.org/licenses/by/4.0/ Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ .
- sha256
- 802123b575c0038b771fd1b9f14ff2f623fb89a9a6e25e3e3d88aeb3c50e8074
- checked At
- 2026-10-24