Neural circuits underlying a psychotherapeutic regimen for fear disorders
Jinhee Baek; Sukchan Lee; Taesup Cho; Seong-Wook Kim; Minsoo Kim; Yongwoo Yoon; Ko Keun Kim; Junweon Byun; Sang Jeong Kim; Jaeseung Jeong; Hee-Sup Shin · Nature · 2019 · Experimental mouse neural-circuit study
Original publication · Original publication · Original publication
Recorded summary
Alternating bilateral visual stimulation during fear extinction recruited a superior-colliculus–thalamus–amygdala circuit in mice and reduced the return of conditioned fear. The experiments identify a possible neural mechanism relevant to eye-movement-based approaches.
Recorded limitations
A mouse model inspired by a psychotherapeutic component; it is not a trial of clinical EMDR or a self-administered treatment in humans.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Experimental mouse neural-circuit study
- assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Experimental mouse neural-circuit study. No masked human randomized trial classification is assigned.
- sources
https://www.nature.com/articles/s41586-019-0931-y · https://doi.org/10.1038/s41586-019-0931-y · https://pubmed.ncbi.nlm.nih.gov/30760920/
- reviewed At
- 2026-10-23
- trust Factor
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-applicable
- peer Reviewed
- true
- basis
- Experimental mouse neural-circuit study. No masked human randomized trial classification is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/30760920/ · https://www.nature.com/articles/s41586-019-0931-y · https://doi.org/10.1038/s41586-019-0931-y
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- evidence Type
- Brain & nervous system
- sample
- Mice
- measurement
- Circuit manipulation, neural activity and conditioned fear
- measured Genes
- None recorded
- relationship Note
- A mouse model inspired by a psychotherapeutic component; it is not a trial of clinical EMDR or a self-administered treatment in humans.
- source URLs
https://www.nature.com/articles/s41586-019-0931-y · https://doi.org/10.1038/s41586-019-0931-y · https://pubmed.ncbi.nlm.nih.gov/30760920/
- checked At
- 2026-10-23
Topics and recorded topic scores
- key
- vision:bilateral-mechanisms
- title
- Bilateral visual stimulation and memory processing
- collection
- vision
- trust Score
- Not recorded
Citation snapshot and identifiers
- id
- pmid-30760920
- doi
- 10.1038/s41586-019-0931-y
- pmid
- 30760920
- citation Snapshot
- count
- 136
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1038/s41586-019-0931-y
- citations By Collection
- vision
- 136
Complete approved library record
- id
- pmid-30760920
- aliases
- None recorded
- title
- Neural circuits underlying a psychotherapeutic regimen for fear disorders
- journal
- Nature
- publisher Family
- nature
- publisher Family Label
- Nature Portfolio
- neurotransmitters
- None recorded
- year
- 2019
- authors
- Jinhee Baek; Sukchan Lee; Taesup Cho; Seong-Wook Kim; Minsoo Kim; Yongwoo Yoon; Ko Keun Kim; Junweon Byun; Sang Jeong Kim; Jaeseung Jeong; Hee-Sup Shin
- design
- Experimental mouse neural-circuit study
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1038/s41586-019-0931-y
- pmid
- 30760920
- urls
https://www.nature.com/articles/s41586-019-0931-y · https://doi.org/10.1038/s41586-019-0931-y · https://pubmed.ncbi.nlm.nih.gov/30760920/
- collections
vision
- categories
Brain & nervous system
- targets
- None recorded
- priority
- 1
- quotes
- None recorded
- summary
- Alternating bilateral visual stimulation during fear extinction recruited a superior-colliculus–thalamus–amygdala circuit in mice and reduced the return of conditioned fear. The experiments identify a possible neural mechanism relevant to eye-movement-based approaches.
- limitation
- A mouse model inspired by a psychotherapeutic component; it is not a trial of clinical EMDR or a self-administered treatment in humans.
- citation Count
- 136
- citation Snapshot
- count
- 136
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1038/s41586-019-0931-y
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Experimental mouse neural-circuit study. No masked human randomized trial classification is assigned.
- sources
https://www.nature.com/articles/s41586-019-0931-y · https://doi.org/10.1038/s41586-019-0931-y · https://pubmed.ncbi.nlm.nih.gov/30760920/
- reviewed At
- 2026-10-23
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-applicable
- peer Reviewed
- true
- basis
- Experimental mouse neural-circuit study. No masked human randomized trial classification is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/30760920/ · https://www.nature.com/articles/s41586-019-0931-y · https://doi.org/10.1038/s41586-019-0931-y
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- vision
- 136
- topics
- key
- vision:bilateral-mechanisms
- title
- Bilateral visual stimulation and memory processing
- collection
- vision
- trust Score
- Not recorded
- journal Key
- nature
- journal Label
- Nature
- chapter Entries
- title
- Neural circuits underlying a psychotherapeutic regimen for fear disorders
- journal
- Nature
- year
- 2019
- authors
- Jinhee Baek; Sukchan Lee; Taesup Cho; Seong-Wook Kim; Minsoo Kim; Yongwoo Yoon; Ko Keun Kim; Junweon Byun; Sang Jeong Kim; Jaeseung Jeong; Hee-Sup Shin
- design
- Experimental mouse neural-circuit study
- urls
https://www.nature.com/articles/s41586-019-0931-y · https://doi.org/10.1038/s41586-019-0931-y · https://pubmed.ncbi.nlm.nih.gov/30760920/
- doi
- 10.1038/s41586-019-0931-y
- pmid
- 30760920
- targets
- None recorded
- neurotransmitters
- None recorded
- categories
Brain & nervous system
- citation Count
- 136
- citation Snapshot
- count
- 136
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1038/s41586-019-0931-y
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Experimental mouse neural-circuit study. No masked human randomized trial classification is assigned.
- sources
https://www.nature.com/articles/s41586-019-0931-y · https://doi.org/10.1038/s41586-019-0931-y · https://pubmed.ncbi.nlm.nih.gov/30760920/
- reviewed At
- 2026-10-23
- evidence
- evidence Type
- Brain & nervous system
- sample
- Mice
- measurement
- Circuit manipulation, neural activity and conditioned fear
- measured Genes
- None recorded
- relationship Note
- A mouse model inspired by a psychotherapeutic component; it is not a trial of clinical EMDR or a self-administered treatment in humans.
- source URLs
https://www.nature.com/articles/s41586-019-0931-y · https://doi.org/10.1038/s41586-019-0931-y · https://pubmed.ncbi.nlm.nih.gov/30760920/
- checked At
- 2026-10-23
- id
- vision-bilateral-mechanisms-pmid-30760920
- record Id
- pmid-30760920
- quotes
- None recorded
- source Pages
- None recorded
- summary
- Alternating bilateral visual stimulation during fear extinction recruited a superior-colliculus–thalamus–amygdala circuit in mice and reduced the return of conditioned fear. The experiments identify a possible neural mechanism relevant to eye-movement-based approaches.
- limitation
- A mouse model inspired by a psychotherapeutic component; it is not a trial of clinical EMDR or a self-administered treatment in humans.
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-applicable
- peer Reviewed
- true
- basis
- Experimental mouse neural-circuit study. No masked human randomized trial classification is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/30760920/ · https://www.nature.com/articles/s41586-019-0931-y · https://doi.org/10.1038/s41586-019-0931-y
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- collection
- vision
- chapter Number
- 5
- topic Id
- bilateral-mechanisms
- topic Title
- Bilateral visual stimulation and memory processing
- trust Score
- Not recorded
- evidence
- evidence Type
- Brain & nervous system
- sample
- Mice
- measurement
- Circuit manipulation, neural activity and conditioned fear
- measured Genes
- None recorded
- relationship Note
- A mouse model inspired by a psychotherapeutic component; it is not a trial of clinical EMDR or a self-administered treatment in humans.
- source URLs
https://www.nature.com/articles/s41586-019-0931-y · https://doi.org/10.1038/s41586-019-0931-y · https://pubmed.ncbi.nlm.nih.gov/30760920/
- checked At
- 2026-10-23
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
- None recorded
- full Text
- status
- not-indexed
- retrieval Available
- false