Pretreatment cortisol predicts trauma-focused psychotherapy response in youth with (partial) posttraumatic stress disorder.
Zantvoord JB, Ensink JBM, Op den Kelder R, Wessel AMA, Lok A, Lindauer RJL. · Psychoneuroendocrinology · 2019 · Prospective biomarker study
Original publication · Original publication
Recorded summary
Among 53 young people aged 8–18 treated with EMDR or trauma-focused CBT, higher pretreatment basal salivary cortisol was associated with greater subsequent symptom improvement.
Recorded limitations
The trauma script rarely produced a cortisol stress response. The predictive contribution was limited and insufficient for clinical application; this is not a gene-expression measurement.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Prospective biomarker study
- assessment
- category
- observational
- peer Reviewed
- true
- basis
- Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/31352130/ · https://doi.org/10.1016/j.psyneuen.2019.104380
- reviewed At
- 2026-10-23
- trust Factor
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/31352130/ · https://doi.org/10.1016/j.psyneuen.2019.104380
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- evidence Type
- Molecular biomarkers
- measured Genes
- None recorded
- relationship Note
- The trauma script rarely produced a cortisol stress response. The predictive contribution was limited and insufficient for clinical application; this is not a gene-expression measurement.
Topics and recorded topic scores
- key
- vision:biomarkers
- title
- EMDR, cortisol and molecular biomarkers
- collection
- vision
- trust Score
- 1
Citation snapshot and identifiers
- id
- pmid-31352130
- doi
- 10.1016/j.psyneuen.2019.104380
- pmid
- 31352130
- citation Snapshot
- count
- 23
- source
- Crossref
- retrieved At
- 2026-10-23
- citations By Collection
- vision
- 23
Complete approved library record
- id
- pmid-31352130
- publication Key
- doi:10.1016/j.psyneuen.2019.104380
- aliases
- None recorded
- title
- Pretreatment cortisol predicts trauma-focused psychotherapy response in youth with (partial) posttraumatic stress disorder.
- journal
- Psychoneuroendocrinology
- neurotransmitters
- None recorded
- year
- 2019
- authors
- Zantvoord JB, Ensink JBM, Op den Kelder R, Wessel AMA, Lok A, Lindauer RJL.
- design
- Prospective biomarker study
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1016/j.psyneuen.2019.104380
- pmid
- 31352130
- urls
https://pubmed.ncbi.nlm.nih.gov/31352130/ · https://doi.org/10.1016/j.psyneuen.2019.104380
- collections
vision
- categories
Molecular biomarkers · Clinical & self-report
- targets
- None recorded
- priority
- 1
- quotes
- None recorded
- summary
- Among 53 young people aged 8–18 treated with EMDR or trauma-focused CBT, higher pretreatment basal salivary cortisol was associated with greater subsequent symptom improvement.
- limitation
- The trauma script rarely produced a cortisol stress response. The predictive contribution was limited and insufficient for clinical application; this is not a gene-expression measurement.
- citation Count
- 23
- citation Snapshot
- count
- 23
- source
- Crossref
- retrieved At
- 2026-10-23
- study Design Assessment
- category
- observational
- peer Reviewed
- true
- basis
- Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/31352130/ · https://doi.org/10.1016/j.psyneuen.2019.104380
- reviewed At
- 2026-10-23
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/31352130/ · https://doi.org/10.1016/j.psyneuen.2019.104380
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- vision
- 23
- topics
- key
- vision:biomarkers
- title
- EMDR, cortisol and molecular biomarkers
- collection
- vision
- trust Score
- 1
- journal Key
- psychoneuroendocrinology
- journal Label
- Psychoneuroendocrinology
- chapter Entries
- title
- Pretreatment cortisol predicts trauma-focused psychotherapy response in youth with (partial) posttraumatic stress disorder.
- journal
- Psychoneuroendocrinology
- year
- 2019
- authors
- Zantvoord JB, Ensink JBM, Op den Kelder R, Wessel AMA, Lok A, Lindauer RJL.
- design
- Prospective biomarker study
- urls
https://pubmed.ncbi.nlm.nih.gov/31352130/ · https://doi.org/10.1016/j.psyneuen.2019.104380
- doi
- 10.1016/j.psyneuen.2019.104380
- pmid
- 31352130
- targets
- None recorded
- categories
Molecular biomarkers · Clinical & self-report
- citation Count
- 23
- citation Snapshot
- count
- 23
- source
- Crossref
- retrieved At
- 2026-10-23
- study Design Assessment
- category
- observational
- peer Reviewed
- true
- basis
- Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/31352130/ · https://doi.org/10.1016/j.psyneuen.2019.104380
- reviewed At
- 2026-10-23
- evidence
- evidence Type
- Molecular biomarkers
- measured Genes
- None recorded
- relationship Note
- The trauma script rarely produced a cortisol stress response. The predictive contribution was limited and insufficient for clinical application; this is not a gene-expression measurement.
- record Id
- pmid-31352130
- quotes
- None recorded
- source Pages
- None recorded
- summary
- Among 53 young people aged 8–18 treated with EMDR or trauma-focused CBT, higher pretreatment basal salivary cortisol was associated with greater subsequent symptom improvement.
- limitation
- The trauma script rarely produced a cortisol stress response. The predictive contribution was limited and insufficient for clinical application; this is not a gene-expression measurement.
- id
- vision-biomarkers-pmid-31352130
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/31352130/ · https://doi.org/10.1016/j.psyneuen.2019.104380
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- publication Key
- doi:10.1016/j.psyneuen.2019.104380
- collection
- vision
- chapter Number
- 4
- topic Id
- biomarkers
- topic Title
- EMDR, cortisol and molecular biomarkers
- trust Score
- 1
- evidence
- evidence Type
- Molecular biomarkers
- measured Genes
- None recorded
- relationship Note
- The trauma script rarely produced a cortisol stress response. The predictive contribution was limited and insufficient for clinical application; this is not a gene-expression measurement.
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- id
- ptsd
- evidence
- field
- title
- text
- Pretreatment cortisol predicts trauma-focused psychotherapy response in youth with (partial) posttraumatic stress disorder.
- matched Text
- posttraumatic stress
- id
- trauma
- evidence
- field
- title
- text
- Pretreatment cortisol predicts trauma-focused psychotherapy response in youth with (partial) posttraumatic stress disorder.
- matched Text
- trauma
- id
- stress
- evidence
- field
- title
- text
- Pretreatment cortisol predicts trauma-focused psychotherapy response in youth with (partial) posttraumatic stress disorder.
- matched Text
- stress
- conditions
ptsd · trauma · stress
- topic Trust Scores
1
- full Text
- status
- not-indexed
- retrieval Available
- false