Successful treatment of post-traumatic stress disorder reverses DNA methylation marks.
Vinkers CH, Geuze E, van Rooij SJH, Kennis M, Schür RR, Nispeling DM, Smith AK, Nievergelt CM, Uddin M, Rutten BPF, Vermetten E, Boks MP. · Molecular Psychiatry · 2019 · Longitudinal molecular cohort
Original publication · Original publication
Recorded summary
In veterans receiving trauma-focused psychotherapy, remission was associated with changes in 12 blood DNA-methylation regions. ZFP57 also showed evidence in an independent prospective deployment cohort.
Recorded limitations
Treatment included trauma-focused CBT and/or EMDR. This observational analysis does not isolate EMDR or establish altered gene expression from methylation alone.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Longitudinal molecular cohort
- assessment
- category
- observational
- peer Reviewed
- true
- basis
- Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/31645664/ · https://doi.org/10.1038/s41380-019-0549-3
- reviewed At
- 2026-10-23
- trust Factor
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/31645664/ · https://doi.org/10.1038/s41380-019-0549-3
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- evidence Type
- Epigenetics
- measured Genes
ZFP57 · APOB · MUC4 · EDN2 · GPX6 · AFF3 · TP73
- relationship Note
- Treatment included trauma-focused CBT and/or EMDR. This observational analysis does not isolate EMDR or establish altered gene expression from methylation alone.
Topics and recorded topic scores
- key
- vision:epigenetics
- title
- EMDR and trauma-focused psychotherapy: DNA methylation
- collection
- vision
- trust Score
- 1
Citation snapshot and identifiers
- id
- pmid-31645664
- doi
- 10.1038/s41380-019-0549-3
- pmid
- 31645664
- citation Snapshot
- count
- 103
- source
- Crossref
- retrieved At
- 2026-10-23
- citations By Collection
- vision
- 103
Complete approved library record
- id
- pmid-31645664
- publication Key
- doi:10.1038/s41380-019-0549-3
- aliases
- None recorded
- title
- Successful treatment of post-traumatic stress disorder reverses DNA methylation marks.
- journal
- Molecular Psychiatry
- publisher Family
- nature
- publisher Family Label
- Nature Portfolio
- neurotransmitters
- None recorded
- year
- 2019
- authors
- Vinkers CH, Geuze E, van Rooij SJH, Kennis M, Schür RR, Nispeling DM, Smith AK, Nievergelt CM, Uddin M, Rutten BPF, Vermetten E, Boks MP.
- design
- Longitudinal molecular cohort
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1038/s41380-019-0549-3
- pmid
- 31645664
- urls
https://pubmed.ncbi.nlm.nih.gov/31645664/ · https://doi.org/10.1038/s41380-019-0549-3
- collections
vision
- categories
Epigenetics · Clinical & self-report
- targets
ZFP57 · APOB · MUC4 · EDN2 · GPX6 · AFF3 · TP73
- priority
- 0
- quotes
- None recorded
- summary
- In veterans receiving trauma-focused psychotherapy, remission was associated with changes in 12 blood DNA-methylation regions. ZFP57 also showed evidence in an independent prospective deployment cohort.
- limitation
- Treatment included trauma-focused CBT and/or EMDR. This observational analysis does not isolate EMDR or establish altered gene expression from methylation alone.
- citation Count
- 103
- citation Snapshot
- count
- 103
- source
- Crossref
- retrieved At
- 2026-10-23
- study Design Assessment
- category
- observational
- peer Reviewed
- true
- basis
- Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/31645664/ · https://doi.org/10.1038/s41380-019-0549-3
- reviewed At
- 2026-10-23
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/31645664/ · https://doi.org/10.1038/s41380-019-0549-3
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- vision
- 103
- topics
- key
- vision:epigenetics
- title
- EMDR and trauma-focused psychotherapy: DNA methylation
- collection
- vision
- trust Score
- 1
- journal Key
- molecularpsychiatry
- journal Label
- Molecular Psychiatry
- chapter Entries
- title
- Successful treatment of post-traumatic stress disorder reverses DNA methylation marks.
- journal
- Molecular Psychiatry
- year
- 2019
- authors
- Vinkers CH, Geuze E, van Rooij SJH, Kennis M, Schür RR, Nispeling DM, Smith AK, Nievergelt CM, Uddin M, Rutten BPF, Vermetten E, Boks MP.
- design
- Longitudinal molecular cohort
- urls
https://pubmed.ncbi.nlm.nih.gov/31645664/ · https://doi.org/10.1038/s41380-019-0549-3
- doi
- 10.1038/s41380-019-0549-3
- pmid
- 31645664
- targets
ZFP57 · APOB · MUC4 · EDN2 · GPX6 · AFF3 · TP73
- categories
Epigenetics · Clinical & self-report
- citation Count
- 103
- citation Snapshot
- count
- 103
- source
- Crossref
- retrieved At
- 2026-10-23
- study Design Assessment
- category
- observational
- peer Reviewed
- true
- basis
- Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/31645664/ · https://doi.org/10.1038/s41380-019-0549-3
- reviewed At
- 2026-10-23
- evidence
- evidence Type
- Epigenetics
- measured Genes
ZFP57 · APOB · MUC4 · EDN2 · GPX6 · AFF3 · TP73
- relationship Note
- Treatment included trauma-focused CBT and/or EMDR. This observational analysis does not isolate EMDR or establish altered gene expression from methylation alone.
- record Id
- pmid-31645664
- quotes
- None recorded
- source Pages
- None recorded
- summary
- In veterans receiving trauma-focused psychotherapy, remission was associated with changes in 12 blood DNA-methylation regions. ZFP57 also showed evidence in an independent prospective deployment cohort.
- limitation
- Treatment included trauma-focused CBT and/or EMDR. This observational analysis does not isolate EMDR or establish altered gene expression from methylation alone.
- id
- vision-epigenetics-pmid-31645664
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/31645664/ · https://doi.org/10.1038/s41380-019-0549-3
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- publication Key
- doi:10.1038/s41380-019-0549-3
- collection
- vision
- chapter Number
- 4
- topic Id
- epigenetics
- topic Title
- EMDR and trauma-focused psychotherapy: DNA methylation
- trust Score
- 1
- evidence
- evidence Type
- Epigenetics
- measured Genes
ZFP57 · APOB · MUC4 · EDN2 · GPX6 · AFF3 · TP73
- relationship Note
- Treatment included trauma-focused CBT and/or EMDR. This observational analysis does not isolate EMDR or establish altered gene expression from methylation alone.
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- id
- ptsd
- evidence
- field
- title
- text
- Successful treatment of post-traumatic stress disorder reverses DNA methylation marks.
- matched Text
- post-traumatic stress
- id
- trauma
- evidence
- field
- title
- text
- Successful treatment of post-traumatic stress disorder reverses DNA methylation marks.
- matched Text
- post-traumatic
- id
- stress
- evidence
- field
- title
- text
- Successful treatment of post-traumatic stress disorder reverses DNA methylation marks.
- matched Text
- stress
- conditions
ptsd · trauma · stress
- topic Trust Scores
1
- full Text
- status
- not-indexed
- retrieval Available
- false