Quantitative cellular-resolution map of the oxytocin receptor in postnatally developing mouse brains
Kyra T. Newmaster; Zachary T. Nolan; Uree Chon; Daniel J. Vanselow; Abigael R. Weit; Manal Tabbaa; Shizu Hidema; Katsuhiko Nishimori; Elizabeth A. D. Hammock; Yongsoo Kim · Nature Communications · 2020 · Experimental developmental brain-mapping study
Original publication · Original publication · Original publication · Original publication
Recorded summary
Cellular-resolution maps show that oxytocin receptor expression changes across brain regions and postnatal development in mice. Reporter imaging and RNA measurements identify transient cortical expression and region-specific patterns, providing an anatomical reference for oxytocin research.
Recorded limitations
Mouse developmental maps do not establish the corresponding receptor distribution or functional connections in the human brain.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Experimental developmental brain-mapping study
- assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Experimental developmental brain-mapping study. No masked human randomized trial classification is assigned.
- sources
https://www.nature.com/articles/s41467-020-15659-1 · https://doi.org/10.1038/s41467-020-15659-1 · https://pmc.ncbi.nlm.nih.gov/articles/PMC7171089/ · https://pubmed.ncbi.nlm.nih.gov/32313029/
- reviewed At
- 2026-10-23
- trust Factor
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Experimental developmental brain-mapping study. No masked human randomized trial classification is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/32313029/ · https://www.nature.com/articles/s41467-020-15659-1 · https://doi.org/10.1038/s41467-020-15659-1 · https://pmc.ncbi.nlm.nih.gov/articles/PMC7171089/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- evidence Type
- Gene expression
- sample
- Postnatally developing mice
- measurement
- Oxytocin receptor reporter imaging and in situ RNA measurements
- measured Genes
OXTR
- relationship Note
- Mouse developmental maps do not establish the corresponding receptor distribution or functional connections in the human brain.
- source URLs
https://www.nature.com/articles/s41467-020-15659-1 · https://doi.org/10.1038/s41467-020-15659-1 · https://pmc.ncbi.nlm.nih.gov/articles/PMC7171089/ · https://pubmed.ncbi.nlm.nih.gov/32313029/
- checked At
- 2026-10-23
Topics and recorded topic scores
- key
- general:oxytocin-sensory
- title
- Oxytocin receptors and sensory experience
- collection
- general
- trust Score
- 1
Citation snapshot and identifiers
- id
- pmid-32313029
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- 10.1038/s41467-020-15659-1
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- 124
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- 2026-10-23
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- https://api.crossref.org/works/10.1038/s41467-020-15659-1
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Complete approved library record
- id
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- aliases
- None recorded
- title
- Quantitative cellular-resolution map of the oxytocin receptor in postnatally developing mouse brains
- journal
- Nature Communications
- publisher Family
- nature
- publisher Family Label
- Nature Portfolio
- neurotransmitters
Oxytocin
- year
- 2020
- authors
- Kyra T. Newmaster; Zachary T. Nolan; Uree Chon; Daniel J. Vanselow; Abigael R. Weit; Manal Tabbaa; Shizu Hidema; Katsuhiko Nishimori; Elizabeth A. D. Hammock; Yongsoo Kim
- design
- Experimental developmental brain-mapping study
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1038/s41467-020-15659-1
- pmid
- 32313029
- urls
https://www.nature.com/articles/s41467-020-15659-1 · https://doi.org/10.1038/s41467-020-15659-1 · https://pmc.ncbi.nlm.nih.gov/articles/PMC7171089/ · https://pubmed.ncbi.nlm.nih.gov/32313029/
- collections
general
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Gene expression
- targets
OXTR
- priority
- 0
- quotes
- None recorded
- summary
- Cellular-resolution maps show that oxytocin receptor expression changes across brain regions and postnatal development in mice. Reporter imaging and RNA measurements identify transient cortical expression and region-specific patterns, providing an anatomical reference for oxytocin research.
- limitation
- Mouse developmental maps do not establish the corresponding receptor distribution or functional connections in the human brain.
- citation Count
- 124
- citation Snapshot
- count
- 124
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1038/s41467-020-15659-1
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Experimental developmental brain-mapping study. No masked human randomized trial classification is assigned.
- sources
https://www.nature.com/articles/s41467-020-15659-1 · https://doi.org/10.1038/s41467-020-15659-1 · https://pmc.ncbi.nlm.nih.gov/articles/PMC7171089/ · https://pubmed.ncbi.nlm.nih.gov/32313029/
- reviewed At
- 2026-10-23
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Experimental developmental brain-mapping study. No masked human randomized trial classification is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/32313029/ · https://www.nature.com/articles/s41467-020-15659-1 · https://doi.org/10.1038/s41467-020-15659-1 · https://pmc.ncbi.nlm.nih.gov/articles/PMC7171089/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- general
- 124
- topics
- key
- general:oxytocin-sensory
- title
- Oxytocin receptors and sensory experience
- collection
- general
- trust Score
- 1
- journal Key
- naturecommunications
- journal Label
- Nature Communications
- chapter Entries
- title
- Quantitative cellular-resolution map of the oxytocin receptor in postnatally developing mouse brains
- journal
- Nature Communications
- year
- 2020
- authors
- Kyra T. Newmaster; Zachary T. Nolan; Uree Chon; Daniel J. Vanselow; Abigael R. Weit; Manal Tabbaa; Shizu Hidema; Katsuhiko Nishimori; Elizabeth A. D. Hammock; Yongsoo Kim
- design
- Experimental developmental brain-mapping study
- urls
https://www.nature.com/articles/s41467-020-15659-1 · https://doi.org/10.1038/s41467-020-15659-1 · https://pmc.ncbi.nlm.nih.gov/articles/PMC7171089/ · https://pubmed.ncbi.nlm.nih.gov/32313029/
- doi
- 10.1038/s41467-020-15659-1
- pmid
- 32313029
- targets
OXTR
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Oxytocin
- categories
Gene expression
- citation Count
- 124
- citation Snapshot
- count
- 124
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1038/s41467-020-15659-1
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Experimental developmental brain-mapping study. No masked human randomized trial classification is assigned.
- sources
https://www.nature.com/articles/s41467-020-15659-1 · https://doi.org/10.1038/s41467-020-15659-1 · https://pmc.ncbi.nlm.nih.gov/articles/PMC7171089/ · https://pubmed.ncbi.nlm.nih.gov/32313029/
- reviewed At
- 2026-10-23
- evidence
- evidence Type
- Gene expression
- sample
- Postnatally developing mice
- measurement
- Oxytocin receptor reporter imaging and in situ RNA measurements
- measured Genes
OXTR
- relationship Note
- Mouse developmental maps do not establish the corresponding receptor distribution or functional connections in the human brain.
- source URLs
https://www.nature.com/articles/s41467-020-15659-1 · https://doi.org/10.1038/s41467-020-15659-1 · https://pmc.ncbi.nlm.nih.gov/articles/PMC7171089/ · https://pubmed.ncbi.nlm.nih.gov/32313029/
- checked At
- 2026-10-23
- id
- general-oxytocin-sensory-pmid-32313029
- record Id
- pmid-32313029
- quotes
- None recorded
- source Pages
- None recorded
- summary
- Cellular-resolution maps show that oxytocin receptor expression changes across brain regions and postnatal development in mice. Reporter imaging and RNA measurements identify transient cortical expression and region-specific patterns, providing an anatomical reference for oxytocin research.
- limitation
- Mouse developmental maps do not establish the corresponding receptor distribution or functional connections in the human brain.
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Experimental developmental brain-mapping study. No masked human randomized trial classification is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/32313029/ · https://www.nature.com/articles/s41467-020-15659-1 · https://doi.org/10.1038/s41467-020-15659-1 · https://pmc.ncbi.nlm.nih.gov/articles/PMC7171089/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- collection
- general
- chapter Number
- 8
- topic Id
- oxytocin-sensory
- topic Title
- Oxytocin receptors and sensory experience
- trust Score
- 1
- evidence
- evidence Type
- Gene expression
- sample
- Postnatally developing mice
- measurement
- Oxytocin receptor reporter imaging and in situ RNA measurements
- measured Genes
OXTR
- relationship Note
- Mouse developmental maps do not establish the corresponding receptor distribution or functional connections in the human brain.
- source URLs
https://www.nature.com/articles/s41467-020-15659-1 · https://doi.org/10.1038/s41467-020-15659-1 · https://pmc.ncbi.nlm.nih.gov/articles/PMC7171089/ · https://pubmed.ncbi.nlm.nih.gov/32313029/
- checked At
- 2026-10-23
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- condition Evidence
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- None recorded
- topic Trust Scores
1
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- https://pmc-oa-opendata.s3.amazonaws.com/PMC7171089.1/PMC7171089.1.xml?md5=23dbae33af352201559e22b452ac2dfe
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- article Rights
© The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/ Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ .
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- checked At
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