Binaural Beats Reduce Postoperative Morphine Consumption in Older adults After Total Knee Replacement Surgery.
Tani A, Vagheggini G, Moretti F, Del Colombo V, Lehle J, Campana S, Labate A, Tomaiuolo F. · Alternative therapies in health and medicine · 2021 · Randomized controlled trial
Recorded summary
In 40 older adults undergoing knee replacement, preoperative 4 Hz binaural beats reduced first-day self-administered morphine from 11.85 to 5.75 mg compared with matched tones presented at the same frequency to both ears.
Recorded limitations
Pain ratings did not differ between groups. This small, single-centre trial supports an opioid-consumption finding in a specific surgical protocol, with broader effectiveness still requiring replication.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Randomized controlled trial
- assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/32412916/
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- trust Factor
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/32412916/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- intervention
- 4 Hz binaural beats, 256/260 Hz carriers
- comparator
- 256 Hz tones in both ears
- evidence Type
- Clinical or experimental outcomes
- source URLs
https://pubmed.ncbi.nlm.nih.gov/32412916/
- checked At
- 2026-10-26
- review Scope
- Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
- discovery Sources
https://daytab.com/study/rbmbb92p · https://europepmc.org/article/MED/32412916
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
Topics and recorded topic scores
- key
- sound:i
- title
- Brain entrainment, pain, anxiety and heart-rate variability
- collection
- sound
- trust Score
- 3
Citation snapshot and identifiers
- id
- pmid-32412916
- doi
- Not recorded
- pmid
- 32412916
- citation Snapshot
- count
- 9
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/32412916
- citations By Collection
- sound
- 9
Complete approved library record
- id
- pmid-32412916
- publication Key
- pmid:32412916
- aliases
- None recorded
- title
- Binaural Beats Reduce Postoperative Morphine Consumption in Older adults After Total Knee Replacement Surgery.
- journal
- Alternative therapies in health and medicine
- neurotransmitters
- None recorded
- year
- 2021
- authors
- Tani A, Vagheggini G, Moretti F, Del Colombo V, Lehle J, Campana S, Labate A, Tomaiuolo F.
- design
- Randomized controlled trial
- identity Conflict
- Not recorded
- doi
- Not recorded
- pmid
- 32412916
- urls
https://pubmed.ncbi.nlm.nih.gov/32412916/
- collections
sound
- categories
Clinical & self-report
- targets
- None recorded
- priority
- 1
- quotes
- None recorded
- summary
- In 40 older adults undergoing knee replacement, preoperative 4 Hz binaural beats reduced first-day self-administered morphine from 11.85 to 5.75 mg compared with matched tones presented at the same frequency to both ears.
- limitation
- Pain ratings did not differ between groups. This small, single-centre trial supports an opioid-consumption finding in a specific surgical protocol, with broader effectiveness still requiring replication.
- citation Count
- 9
- citation Snapshot
- count
- 9
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/32412916
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/32412916/
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/32412916/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- sound
- 9
- topics
- key
- sound:i
- title
- Brain entrainment, pain, anxiety and heart-rate variability
- collection
- sound
- trust Score
- 3
- journal Key
- alternativetherapiesinhealthandmedicine
- journal Label
- Alternative therapies in health and medicine
- chapter Entries
- title
- Binaural Beats Reduce Postoperative Morphine Consumption in Older adults After Total Knee Replacement Surgery.
- journal
- Alternative therapies in health and medicine
- year
- 2021
- authors
- Tani A, Vagheggini G, Moretti F, Del Colombo V, Lehle J, Campana S, Labate A, Tomaiuolo F.
- design
- Randomized controlled trial
- urls
https://pubmed.ncbi.nlm.nih.gov/32412916/
- doi
- Not recorded
- pmid
- 32412916
- targets
- None recorded
- categories
Clinical & self-report
- citation Count
- 9
- citation Snapshot
- count
- 9
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/32412916
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/32412916/
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- evidence
- intervention
- 4 Hz binaural beats, 256/260 Hz carriers
- comparator
- 256 Hz tones in both ears
- evidence Type
- Clinical or experimental outcomes
- source URLs
https://pubmed.ncbi.nlm.nih.gov/32412916/
- checked At
- 2026-10-26
- review Scope
- Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
- discovery Sources
https://daytab.com/study/rbmbb92p · https://europepmc.org/article/MED/32412916
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
- id
- sound-i-pmid-32412916
- record Id
- pmid-32412916
- quotes
- None recorded
- source Pages
- None recorded
- summary
- In 40 older adults undergoing knee replacement, preoperative 4 Hz binaural beats reduced first-day self-administered morphine from 11.85 to 5.75 mg compared with matched tones presented at the same frequency to both ears.
- limitation
- Pain ratings did not differ between groups. This small, single-centre trial supports an opioid-consumption finding in a specific surgical protocol, with broader effectiveness still requiring replication.
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/32412916/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- publication Key
- pmid:32412916
- collection
- sound
- chapter Number
- 1
- topic Id
- i
- topic Title
- Brain entrainment, pain, anxiety and heart-rate variability
- trust Score
- 3
- evidence
- intervention
- 4 Hz binaural beats, 256/260 Hz carriers
- comparator
- 256 Hz tones in both ears
- evidence Type
- Clinical or experimental outcomes
- source URLs
https://pubmed.ncbi.nlm.nih.gov/32412916/
- checked At
- 2026-10-26
- review Scope
- Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
- discovery Sources
https://daytab.com/study/rbmbb92p · https://europepmc.org/article/MED/32412916
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
3
- full Text
- status
- not-indexed
- retrieval Available
- false