Reduced pain and analgesic use after acoustic binaural beats therapy in chronic pain - A double-blind randomized control cross-over trial.
Gkolias V, Amaniti A, Triantafyllou A, Papakonstantinou P, Kartsidis P, Paraskevopoulos E, Bamidis PD, Hadjileontiadis L, Kouvelas D. · European journal of pain (London, England) · 2020 · Double-blind randomized crossover trial
Original publication · Original publication
Recorded summary
A sham-controlled crossover study reported lower pain ratings and analgesic use after 5 Hz binaural stimulation in people with chronic pain, together with increased EEG power at the stimulation frequency.
Recorded limitations
Sample size and participant flow require full-text appraisal. The short treatment periods and crossover design limit conclusions about sustained benefit or wider patient populations.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Double-blind randomized crossover trial
- assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/32564499/ · https://doi.org/10.1002/ejp.1615
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- trust Factor
- score
- 3
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- double
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/32564499/ · https://doi.org/10.1002/ejp.1615
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- intervention
- 5 Hz binaural beats for chronic pain
- comparator
- Sham stimulation
- evidence Type
- Clinical or experimental outcomes
- source URLs
https://pubmed.ncbi.nlm.nih.gov/32564499/ · https://doi.org/10.1002/ejp.1615
- checked At
- 2026-10-26
- review Scope
- Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
- discovery Sources
https://europepmc.org/article/MED/32564499
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
Topics and recorded topic scores
- key
- sound:i
- title
- Brain entrainment, pain, anxiety and heart-rate variability
- collection
- sound
- trust Score
- 3
Citation snapshot and identifiers
- id
- pmid-32564499
- doi
- 10.1002/ejp.1615
- pmid
- 32564499
- citation Snapshot
- count
- 19
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/32564499
- citations By Collection
- sound
- 19
Complete approved library record
- id
- pmid-32564499
- publication Key
- doi:10.1002/ejp.1615
- aliases
- None recorded
- title
- Reduced pain and analgesic use after acoustic binaural beats therapy in chronic pain - A double-blind randomized control cross-over trial.
- journal
- European journal of pain (London, England)
- neurotransmitters
- None recorded
- year
- 2020
- authors
- Gkolias V, Amaniti A, Triantafyllou A, Papakonstantinou P, Kartsidis P, Paraskevopoulos E, Bamidis PD, Hadjileontiadis L, Kouvelas D.
- design
- Double-blind randomized crossover trial
- identity Conflict
- Not recorded
- doi
- 10.1002/ejp.1615
- pmid
- 32564499
- urls
https://pubmed.ncbi.nlm.nih.gov/32564499/ · https://doi.org/10.1002/ejp.1615
- collections
sound
- categories
Clinical & self-report
- targets
- None recorded
- priority
- 1
- quotes
- None recorded
- summary
- A sham-controlled crossover study reported lower pain ratings and analgesic use after 5 Hz binaural stimulation in people with chronic pain, together with increased EEG power at the stimulation frequency.
- limitation
- Sample size and participant flow require full-text appraisal. The short treatment periods and crossover design limit conclusions about sustained benefit or wider patient populations.
- citation Count
- 19
- citation Snapshot
- count
- 19
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/32564499
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/32564499/ · https://doi.org/10.1002/ejp.1615
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- paper Trust Assessment
- score
- 3
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- double
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/32564499/ · https://doi.org/10.1002/ejp.1615
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- sound
- 19
- topics
- key
- sound:i
- title
- Brain entrainment, pain, anxiety and heart-rate variability
- collection
- sound
- trust Score
- 3
- journal Key
- europeanjournalofpain
- journal Label
- European journal of pain (London, England)
- chapter Entries
- title
- Reduced pain and analgesic use after acoustic binaural beats therapy in chronic pain - A double-blind randomized control cross-over trial.
- journal
- European journal of pain (London, England)
- year
- 2020
- authors
- Gkolias V, Amaniti A, Triantafyllou A, Papakonstantinou P, Kartsidis P, Paraskevopoulos E, Bamidis PD, Hadjileontiadis L, Kouvelas D.
- design
- Double-blind randomized crossover trial
- urls
https://pubmed.ncbi.nlm.nih.gov/32564499/ · https://doi.org/10.1002/ejp.1615
- doi
- 10.1002/ejp.1615
- pmid
- 32564499
- targets
- None recorded
- categories
Clinical & self-report
- citation Count
- 19
- citation Snapshot
- count
- 19
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/32564499
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/32564499/ · https://doi.org/10.1002/ejp.1615
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- evidence
- intervention
- 5 Hz binaural beats for chronic pain
- comparator
- Sham stimulation
- evidence Type
- Clinical or experimental outcomes
- source URLs
https://pubmed.ncbi.nlm.nih.gov/32564499/ · https://doi.org/10.1002/ejp.1615
- checked At
- 2026-10-26
- review Scope
- Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
- discovery Sources
https://europepmc.org/article/MED/32564499
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
- id
- sound-i-pmid-32564499
- record Id
- pmid-32564499
- quotes
- None recorded
- source Pages
- None recorded
- summary
- A sham-controlled crossover study reported lower pain ratings and analgesic use after 5 Hz binaural stimulation in people with chronic pain, together with increased EEG power at the stimulation frequency.
- limitation
- Sample size and participant flow require full-text appraisal. The short treatment periods and crossover design limit conclusions about sustained benefit or wider patient populations.
- paper Trust Assessment
- score
- 3
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- double
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/32564499/ · https://doi.org/10.1002/ejp.1615
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- publication Key
- doi:10.1002/ejp.1615
- collection
- sound
- chapter Number
- 1
- topic Id
- i
- topic Title
- Brain entrainment, pain, anxiety and heart-rate variability
- trust Score
- 3
- evidence
- intervention
- 5 Hz binaural beats for chronic pain
- comparator
- Sham stimulation
- evidence Type
- Clinical or experimental outcomes
- source URLs
https://pubmed.ncbi.nlm.nih.gov/32564499/ · https://doi.org/10.1002/ejp.1615
- checked At
- 2026-10-26
- review Scope
- Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
- discovery Sources
https://europepmc.org/article/MED/32564499
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
3
- full Text
- status
- not-indexed
- retrieval Available
- false