Effect of Mindfulness Meditation on Intraocular Pressure and Trabecular Meshwork Gene Expression: A Randomized Controlled Trial.
Dada T, Bhai N, Midha N, Shakrawal J, Kumar M, Chaurasia P, Gupta S, Angmo D, Yadav R, Dada R, Sihota R. · American journal of ophthalmology · 2021 · Single-blind randomized controlled trial
Original publication · Original publication
Recorded summary
In 60 glaucoma patients, a three-week meditation adjunct reduced intraocular pressure relative to medication alone and was associated with trabecular-meshwork expression changes involving nitric-oxide and inflammatory pathways.
Recorded limitations
The measured tissue was ocular rather than brain tissue. The short, small trial and multiple molecular endpoints do not establish a general genomic mechanism or replacement for glaucoma care.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Single-blind randomized controlled trial
- assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/33393484/ · https://doi.org/10.1016/j.ajo.2020.10.012
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- trust Factor
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- single
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/33393484/ · https://doi.org/10.1016/j.ajo.2020.10.012
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- intervention
- Three-week meditation adjunct
- comparator
- Glaucoma medication alone
- evidence Type
- Gene expression
- source URLs
https://pubmed.ncbi.nlm.nih.gov/33393484/ · https://doi.org/10.1016/j.ajo.2020.10.012
- checked At
- 2026-10-26
- review Scope
- Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
- discovery Sources
https://daytab.com/study/b5xzgp8h · https://europepmc.org/article/MED/33393484
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
- measurement
- Trabecular-meshwork gene expression and intraocular pressure
- measured Genes
NOS1 · NOS3
- sample
- 60 glaucoma patients
Topics and recorded topic scores
- key
- language:mindfulness-rna
- title
- Mindfulness interventions and gene expression
- collection
- language
- trust Score
- 2
Citation snapshot and identifiers
- id
- pmid-33393484
- doi
- 10.1016/j.ajo.2020.10.012
- pmid
- 33393484
- citation Snapshot
- count
- 32
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/33393484
- citations By Collection
- language
- 32
Complete approved library record
- id
- pmid-33393484
- publication Key
- doi:10.1016/j.ajo.2020.10.012
- aliases
- None recorded
- title
- Effect of Mindfulness Meditation on Intraocular Pressure and Trabecular Meshwork Gene Expression: A Randomized Controlled Trial.
- journal
- American journal of ophthalmology
- neurotransmitters
- None recorded
- year
- 2021
- authors
- Dada T, Bhai N, Midha N, Shakrawal J, Kumar M, Chaurasia P, Gupta S, Angmo D, Yadav R, Dada R, Sihota R.
- design
- Single-blind randomized controlled trial
- identity Conflict
- Not recorded
- doi
- 10.1016/j.ajo.2020.10.012
- pmid
- 33393484
- urls
https://pubmed.ncbi.nlm.nih.gov/33393484/ · https://doi.org/10.1016/j.ajo.2020.10.012
- collections
language
- categories
Gene expression
- targets
NOS1 · NOS3
- priority
- 0
- quotes
- None recorded
- summary
- In 60 glaucoma patients, a three-week meditation adjunct reduced intraocular pressure relative to medication alone and was associated with trabecular-meshwork expression changes involving nitric-oxide and inflammatory pathways.
- limitation
- The measured tissue was ocular rather than brain tissue. The short, small trial and multiple molecular endpoints do not establish a general genomic mechanism or replacement for glaucoma care.
- citation Count
- 32
- citation Snapshot
- count
- 32
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/33393484
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/33393484/ · https://doi.org/10.1016/j.ajo.2020.10.012
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- single
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/33393484/ · https://doi.org/10.1016/j.ajo.2020.10.012
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- language
- 32
- topics
- key
- language:mindfulness-rna
- title
- Mindfulness interventions and gene expression
- collection
- language
- trust Score
- 2
- journal Key
- americanjournalofophthalmology
- journal Label
- American journal of ophthalmology
- chapter Entries
- title
- Effect of Mindfulness Meditation on Intraocular Pressure and Trabecular Meshwork Gene Expression: A Randomized Controlled Trial.
- journal
- American journal of ophthalmology
- year
- 2021
- authors
- Dada T, Bhai N, Midha N, Shakrawal J, Kumar M, Chaurasia P, Gupta S, Angmo D, Yadav R, Dada R, Sihota R.
- design
- Single-blind randomized controlled trial
- urls
https://pubmed.ncbi.nlm.nih.gov/33393484/ · https://doi.org/10.1016/j.ajo.2020.10.012
- doi
- 10.1016/j.ajo.2020.10.012
- pmid
- 33393484
- targets
NOS1 · NOS3
- categories
Gene expression
- citation Count
- 32
- citation Snapshot
- count
- 32
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/33393484
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/33393484/ · https://doi.org/10.1016/j.ajo.2020.10.012
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- evidence
- intervention
- Three-week meditation adjunct
- comparator
- Glaucoma medication alone
- evidence Type
- Gene expression
- source URLs
https://pubmed.ncbi.nlm.nih.gov/33393484/ · https://doi.org/10.1016/j.ajo.2020.10.012
- checked At
- 2026-10-26
- review Scope
- Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
- discovery Sources
https://daytab.com/study/b5xzgp8h · https://europepmc.org/article/MED/33393484
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
- measurement
- Trabecular-meshwork gene expression and intraocular pressure
- measured Genes
NOS1 · NOS3
- sample
- 60 glaucoma patients
- id
- language-mindfulness-rna-pmid-33393484
- record Id
- pmid-33393484
- quotes
- None recorded
- source Pages
- None recorded
- summary
- In 60 glaucoma patients, a three-week meditation adjunct reduced intraocular pressure relative to medication alone and was associated with trabecular-meshwork expression changes involving nitric-oxide and inflammatory pathways.
- limitation
- The measured tissue was ocular rather than brain tissue. The short, small trial and multiple molecular endpoints do not establish a general genomic mechanism or replacement for glaucoma care.
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- single
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/33393484/ · https://doi.org/10.1016/j.ajo.2020.10.012
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- publication Key
- doi:10.1016/j.ajo.2020.10.012
- collection
- language
- chapter Number
- 4
- topic Id
- mindfulness-rna
- topic Title
- Mindfulness interventions and gene expression
- trust Score
- 2
- evidence
- intervention
- Three-week meditation adjunct
- comparator
- Glaucoma medication alone
- evidence Type
- Gene expression
- source URLs
https://pubmed.ncbi.nlm.nih.gov/33393484/ · https://doi.org/10.1016/j.ajo.2020.10.012
- checked At
- 2026-10-26
- review Scope
- Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
- discovery Sources
https://daytab.com/study/b5xzgp8h · https://europepmc.org/article/MED/33393484
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
- measurement
- Trabecular-meshwork gene expression and intraocular pressure
- measured Genes
NOS1 · NOS3
- sample
- 60 glaucoma patients
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
2
- full Text
- status
- not-indexed
- retrieval Available
- false