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Theta burst stimulation for the acute treatment of major depressive disorder: A systematic review and meta-analysis

Voigt JD, Leuchter AF, Carpenter LL. · Translational Psychiatry · 2021

Original publication · Original publication · Original publication

Attributed extracts from the research record

“We screened 195 articles identified upon search from PubMed, EBSCO/CINAHL, and CENTRAL; 23 were retrieved for inclusion assessment. Ultimately 10 articles were included in the meta-analyses . Of these, nine were single-center trials and one was a multicenter Canadian study1. Four studies took place in Germany two in Taiwan and one each in Australia, Belgium, Canada, and Israel”
“The finding of positive effects of TBS on major depressive disorder confirm prior meta-analyses, expand upon prior findings, and support the growing interest in application of TBS protocols for treating neuropsychiatric disorders such as major depressive disorder.”

Evidence and provenance

Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.

Study design and assessment
design
assessment
Not recorded
trust Factor
score
1
scope
Paper
status
assessed
randomized Controlled Trial
false
blinding
not-applicable
peer Reviewed
true
basis
Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
sources

https://pubmed.ncbi.nlm.nih.gov/34050123/ · https://doi.org/10.1038/s41398-021-01441-4 · https://www.nature.com/articles/s41398-021-01441-4

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
jadad
status
unassessed
score
Not recorded
evidence
Not recorded
Topics and recorded topic scores
  1. key
    sound:iii
    title
    7.83 Hz and low-frequency electromagnetic research
    collection
    sound
    trust Score
    2
  2. key
    general:sound-iii
    title
    7.83 Hz and low-frequency electromagnetic research
    collection
    general
    trust Score
    2
Citation snapshot and identifiers
id
pmid-34050123
doi
10.1038/s41398-021-01441-4
pmid
34050123
citation Snapshot
Not recorded
citations By Collection
sound
Not recorded
general
Not recorded
Complete approved library record
id
pmid-34050123
publication Key
Not recorded
aliases
None recorded
title
Theta burst stimulation for the acute treatment of major depressive disorder: A systematic review and meta-analysis
journal
Translational Psychiatry
publisher Family
nature
publisher Family Label
Nature Portfolio
neurotransmitters
None recorded
year
2021
authors
Voigt JD, Leuchter AF, Carpenter LL.
design
kind
Review / synthesis
identity Conflict
Not recorded
doi
10.1038/s41398-021-01441-4
pmid
34050123
urls

https://doi.org/10.1038/s41398-021-01441-4 · https://www.nature.com/articles/s41398-021-01441-4 · https://pubmed.ncbi.nlm.nih.gov/34050123/

collections

sound · general

categories

Methods & context

targets
None recorded
priority
1
quotes

“We screened 195 articles identified upon search from PubMed, EBSCO/CINAHL, and CENTRAL; 23 were retrieved for inclusion assessment. Ultimately 10 articles were included in the meta-analyses . Of these, nine were single-center trials and one was a multicenter Canadian study1. Four studies took place in Germany two in Taiwan and one each in Australia, Belgium, Canada, and Israel” · “The finding of positive effects of TBS on major depressive disorder confirm prior meta-analyses, expand upon prior findings, and support the growing interest in application of TBS protocols for treating neuropsychiatric disorders such as major depressive disorder.”

summary
limitation
citation Count
Not recorded
paper Trust Assessment
score
1
scope
Paper
status
assessed
randomized Controlled Trial
false
blinding
not-applicable
peer Reviewed
true
basis
Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
sources

https://pubmed.ncbi.nlm.nih.gov/34050123/ · https://doi.org/10.1038/s41398-021-01441-4 · https://www.nature.com/articles/s41398-021-01441-4

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
citations By Collection
sound
Not recorded
general
Not recorded
topics
  1. key
    sound:iii
    title
    7.83 Hz and low-frequency electromagnetic research
    collection
    sound
    trust Score
    2
  2. key
    general:sound-iii
    title
    7.83 Hz and low-frequency electromagnetic research
    collection
    general
    trust Score
    2
journal Key
translationalpsychiatry
journal Label
Translational Psychiatry
chapter Entries
  1. id
    iii-pmid-34050123
    record Id
    pmid-34050123
    title
    Theta burst stimulation for the acute treatment of major depressive disorder: A systematic review and meta-analysis
    journal
    Translational Psychiatry
    year
    2021
    authors
    Voigt JD, Leuchter AF, Carpenter LL.
    design
    urls

    https://doi.org/10.1038/s41398-021-01441-4 · https://www.nature.com/articles/s41398-021-01441-4 · https://pubmed.ncbi.nlm.nih.gov/34050123/

    quotes
      1. text
        “We screened
        emphasis
        false
      2. text
        195 articles
        emphasis
        true
      3. text
        identified upon search from PubMed, EBSCO/CINAHL, and CENTRAL; 23 were retrieved for inclusion assessment. Ultimately
        emphasis
        false
      4. text
        10 articles were included in the meta-analyses
        emphasis
        true
      5. text
        . Of these, nine were single-center trials and one was a multicenter Canadian study1. Four studies took place in Germany two in Taiwan and one each in Australia, Belgium, Canada, and Israel”
        emphasis
        false
      1. text
        “The finding of
        emphasis
        false
      2. text
        positive effects of TBS on major depressive disorder
        emphasis
        true
      3. text
        confirm prior meta-analyses, expand upon prior findings, and support the growing interest in application of TBS protocols for treating neuropsychiatric disorders such as major depressive disorder.”
        emphasis
        false
    citation Count
    Not recorded
    source Pages

    21

    targets
    None recorded
    categories

    Methods & context

    doi
    10.1038/s41398-021-01441-4
    pmid
    34050123
    paper Trust Assessment
    score
    1
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    false
    blinding
    not-applicable
    peer Reviewed
    true
    basis
    Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
    sources

    https://pubmed.ncbi.nlm.nih.gov/34050123/ · https://doi.org/10.1038/s41398-021-01441-4 · https://www.nature.com/articles/s41398-021-01441-4

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    collection
    sound
    chapter Number
    1
    topic Id
    iii
    topic Title
    7.83 Hz and low-frequency electromagnetic research
    trust Score
    2
  2. id
    general-iii-pmid-34050123
    record Id
    pmid-34050123
    title
    Theta burst stimulation for the acute treatment of major depressive disorder: A systematic review and meta-analysis
    journal
    Translational Psychiatry
    year
    2021
    authors
    Voigt JD, Leuchter AF, Carpenter LL.
    design
    urls

    https://doi.org/10.1038/s41398-021-01441-4 · https://www.nature.com/articles/s41398-021-01441-4 · https://pubmed.ncbi.nlm.nih.gov/34050123/

    quotes
      1. text
        “We screened
        emphasis
        false
      2. text
        195 articles
        emphasis
        true
      3. text
        identified upon search from PubMed, EBSCO/CINAHL, and CENTRAL; 23 were retrieved for inclusion assessment. Ultimately
        emphasis
        false
      4. text
        10 articles were included in the meta-analyses
        emphasis
        true
      5. text
        . Of these, nine were single-center trials and one was a multicenter Canadian study1. Four studies took place in Germany two in Taiwan and one each in Australia, Belgium, Canada, and Israel”
        emphasis
        false
      1. text
        “The finding of
        emphasis
        false
      2. text
        positive effects of TBS on major depressive disorder
        emphasis
        true
      3. text
        confirm prior meta-analyses, expand upon prior findings, and support the growing interest in application of TBS protocols for treating neuropsychiatric disorders such as major depressive disorder.”
        emphasis
        false
    citation Count
    Not recorded
    source Pages

    21

    targets
    None recorded
    categories

    Methods & context

    doi
    10.1038/s41398-021-01441-4
    pmid
    34050123
    paper Trust Assessment
    score
    1
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    false
    blinding
    not-applicable
    peer Reviewed
    true
    basis
    Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
    sources

    https://pubmed.ncbi.nlm.nih.gov/34050123/ · https://doi.org/10.1038/s41398-021-01441-4 · https://www.nature.com/articles/s41398-021-01441-4

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    collection
    general
    chapter Number
    2
    topic Id
    sound-iii
    topic Title
    7.83 Hz and low-frequency electromagnetic research
    trust Score
    2
jadad
status
unassessed
score
Not recorded
condition Evidence
  1. id
    depression
    evidence
    1. field
      title
      text
      Theta burst stimulation for the acute treatment of major depressive disorder: A systematic review and meta-analysis
      matched Text
      depressive
conditions

depression

topic Trust Scores

2

full Text
status
open-license
retrieval Available
true
url
https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8163818/fullTextXML
pmcid
PMC8163818
rights
license
https://creativecommons.org/licenses/by/4.0/
statement

© The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/ Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ .

sha256
c431b0972a064da72165f77d5b55bf59d924acac09246594e17d47670ee29e32
checked At
2026-10-24

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