Inflammation-related microRNAs are involved in stressful life events exposure and in trauma-focused psychotherapy in treatment-resistant depressed patients.
Maffioletti E, Bocchio-Chiavetto L, Perusi G, Carvalho Silva R, Sacco C, Bazzanella R, Zampieri E, Bortolomasi M, Gennarelli M, Minelli A. · European journal of psychotraumatology · 2021 · Longitudinal molecular study
Original publication · Original publication · Original publication
Recorded summary
Blood microRNA was measured in 41 people with treatment-resistant depression; 21 received EMDR or trauma-focused CBT. miR-15a, miR-29a, miR-126, miR-195 and let-7f changed during treatment; baseline miR-29a was associated with response.
Recorded limitations
The longitudinal group combined 12 EMDR and nine CBT participants. This cohort also informs the 2023 stress-gene paper, so the two publications are not independent replications.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Longitudinal molecular study
- assessment
- category
- observational
- peer Reviewed
- true
- basis
- Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/35070159/ · https://doi.org/10.1080/20008198.2021.1987655
- reviewed At
- 2026-10-23
- trust Factor
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/35070159/ · https://doi.org/10.1080/20008198.2021.1987655
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- evidence Type
- Genomics & gene expression
- measured Genes
MIR15A · MIR29A · MIR126 · MIR195 · MIRLET7F · MIR146A
- relationship Note
- The longitudinal group combined 12 EMDR and nine CBT participants. This cohort also informs the 2023 stress-gene paper, so the two publications are not independent replications.
- sample
- 41 baseline; 21 longitudinal (12 EMDR, 9 TF-CBT)
- measurement
- Whole-blood microRNA expression
- trial Id
- Brescia-TRD-21
Topics and recorded topic scores
- key
- vision:rna
- title
- EMDR and trauma-focused psychotherapy: gene expression
- collection
- vision
- trust Score
- Not recorded
Citation snapshot and identifiers
- id
- pmid-35070159
- doi
- 10.1080/20008198.2021.1987655
- pmid
- 35070159
- citation Snapshot
- count
- 36
- source
- Crossref
- retrieved At
- 2026-10-23
- citations By Collection
- vision
- 36
Complete approved library record
- id
- pmid-35070159
- publication Key
- doi:10.1080/20008198.2021.1987655
- aliases
- None recorded
- title
- Inflammation-related microRNAs are involved in stressful life events exposure and in trauma-focused psychotherapy in treatment-resistant depressed patients.
- journal
- European journal of psychotraumatology
- neurotransmitters
- None recorded
- year
- 2021
- authors
- Maffioletti E, Bocchio-Chiavetto L, Perusi G, Carvalho Silva R, Sacco C, Bazzanella R, Zampieri E, Bortolomasi M, Gennarelli M, Minelli A.
- design
- Longitudinal molecular study
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1080/20008198.2021.1987655
- pmid
- 35070159
- urls
https://pmc.ncbi.nlm.nih.gov/articles/PMC8772504/ · https://pubmed.ncbi.nlm.nih.gov/35070159/ · https://doi.org/10.1080/20008198.2021.1987655
- collections
vision
- categories
Genomics & gene expression · Clinical & self-report
- targets
MIR15A · MIR29A · MIR126 · MIR195 · MIRLET7F · MIR146A
- priority
- 0
- quotes
- None recorded
- summary
- Blood microRNA was measured in 41 people with treatment-resistant depression; 21 received EMDR or trauma-focused CBT. miR-15a, miR-29a, miR-126, miR-195 and let-7f changed during treatment; baseline miR-29a was associated with response.
- limitation
- The longitudinal group combined 12 EMDR and nine CBT participants. This cohort also informs the 2023 stress-gene paper, so the two publications are not independent replications.
- citation Count
- 36
- citation Snapshot
- count
- 36
- source
- Crossref
- retrieved At
- 2026-10-23
- study Design Assessment
- category
- observational
- peer Reviewed
- true
- basis
- Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/35070159/ · https://doi.org/10.1080/20008198.2021.1987655
- reviewed At
- 2026-10-23
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/35070159/ · https://doi.org/10.1080/20008198.2021.1987655
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- vision
- 36
- topics
- key
- vision:rna
- title
- EMDR and trauma-focused psychotherapy: gene expression
- collection
- vision
- trust Score
- Not recorded
- journal Key
- europeanjournalofpsychotraumatology
- journal Label
- European journal of psychotraumatology
- chapter Entries
- title
- Inflammation-related microRNAs are involved in stressful life events exposure and in trauma-focused psychotherapy in treatment-resistant depressed patients.
- journal
- European journal of psychotraumatology
- year
- 2021
- authors
- Maffioletti E, Bocchio-Chiavetto L, Perusi G, Carvalho Silva R, Sacco C, Bazzanella R, Zampieri E, Bortolomasi M, Gennarelli M, Minelli A.
- design
- Longitudinal molecular study
- urls
https://pmc.ncbi.nlm.nih.gov/articles/PMC8772504/ · https://pubmed.ncbi.nlm.nih.gov/35070159/ · https://doi.org/10.1080/20008198.2021.1987655
- doi
- 10.1080/20008198.2021.1987655
- pmid
- 35070159
- targets
MIR15A · MIR29A · MIR126 · MIR195 · MIRLET7F · MIR146A
- categories
Genomics & gene expression · Clinical & self-report
- citation Count
- 36
- citation Snapshot
- count
- 36
- source
- Crossref
- retrieved At
- 2026-10-23
- study Design Assessment
- category
- observational
- peer Reviewed
- true
- basis
- Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/35070159/ · https://doi.org/10.1080/20008198.2021.1987655
- reviewed At
- 2026-10-23
- evidence
- evidence Type
- Genomics & gene expression
- measured Genes
MIR15A · MIR29A · MIR126 · MIR195 · MIRLET7F · MIR146A
- relationship Note
- The longitudinal group combined 12 EMDR and nine CBT participants. This cohort also informs the 2023 stress-gene paper, so the two publications are not independent replications.
- sample
- 41 baseline; 21 longitudinal (12 EMDR, 9 TF-CBT)
- measurement
- Whole-blood microRNA expression
- trial Id
- Brescia-TRD-21
- record Id
- pmid-35070159
- quotes
- None recorded
- source Pages
- None recorded
- summary
- Blood microRNA was measured in 41 people with treatment-resistant depression; 21 received EMDR or trauma-focused CBT. miR-15a, miR-29a, miR-126, miR-195 and let-7f changed during treatment; baseline miR-29a was associated with response.
- limitation
- The longitudinal group combined 12 EMDR and nine CBT participants. This cohort also informs the 2023 stress-gene paper, so the two publications are not independent replications.
- id
- vision-rna-pmid-35070159
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/35070159/ · https://doi.org/10.1080/20008198.2021.1987655
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- publication Key
- doi:10.1080/20008198.2021.1987655
- collection
- vision
- chapter Number
- 4
- topic Id
- rna
- topic Title
- EMDR and trauma-focused psychotherapy: gene expression
- trust Score
- Not recorded
- evidence
- evidence Type
- Genomics & gene expression
- measured Genes
MIR15A · MIR29A · MIR126 · MIR195 · MIRLET7F · MIR146A
- relationship Note
- The longitudinal group combined 12 EMDR and nine CBT participants. This cohort also informs the 2023 stress-gene paper, so the two publications are not independent replications.
- sample
- 41 baseline; 21 longitudinal (12 EMDR, 9 TF-CBT)
- measurement
- Whole-blood microRNA expression
- trial Id
- Brescia-TRD-21
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- id
- trauma
- evidence
- field
- title
- text
- Inflammation-related microRNAs are involved in stressful life events exposure and in trauma-focused psychotherapy in treatment-resistant depressed patients.
- matched Text
- trauma
- id
- depression
- evidence
- field
- title
- text
- Inflammation-related microRNAs are involved in stressful life events exposure and in trauma-focused psychotherapy in treatment-resistant depressed patients.
- matched Text
- depressed
- conditions
trauma · depression
- topic Trust Scores
- None recorded
- full Text
- status
- not-indexed
- retrieval Available
- false