Smartphone mindfulness meditation training reduces Pro-inflammatory gene expression in stressed adults: A randomized controlled trial
Dutcher JM, Cole SW, Williams AC, Creswell JD. · Brain, behavior, and immunity · 2022 · Randomized controlled trial; registered single-blind (outcome assessors)
Original publication · Original publication
Recorded summary
Mindfulness training reduced inferred NF-κB activity relative to the active comparison programme. Stress decreased in both groups, without a significant difference between them.
Recorded limitations
The molecular result concerns an inferred transcription-control pathway. It does not establish a measured change in every NF-κB-related gene or a clinical treatment effect.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Randomized controlled trial; registered single-blind (outcome assessors)
- assessment
- basis
- The linked trial register specifies masked outcome assessors. The experimenter setting up the apps knew the assigned condition.
- sources
https://pubmed.ncbi.nlm.nih.gov/35427760/ · https://doi.org/10.1016/j.bbi.2022.04.003 · https://clinicaltrials.gov/study/NCT03803865 · https://www.healthandhumanperformancelab.com/_files/ugd/b30fc8_81ef3b38218542ec880d0700d6e1dec1.pdf
- assessed At
- 2026-10-23
- registered Masking Basis
- true
- category
- single-blind-rct
- peer Reviewed
- true
- trust Factor
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- single
- peer Reviewed
- true
- basis
- The linked trial register specifies masked outcome assessors. The experimenter setting up the apps knew the assigned condition.
- sources
https://pubmed.ncbi.nlm.nih.gov/35427760/ · https://doi.org/10.1016/j.bbi.2022.04.003 · https://clinicaltrials.gov/study/NCT03803865 · https://www.healthandhumanperformancelab.com/_files/ugd/b30fc8_81ef3b38218542ec880d0700d6e1dec1.pdf
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- intervention
- Smartphone mindfulness meditation
- comparator
- Problem-solving programme
- sample
- Stressed customer-service workers
- measurement
- Immune-cell gene expression; promoter-based pathway analysis
- timing
- 30 days
- trial Id
- NCT03803865
- measured Genes
- None recorded
- pathways
NF-κB
- evidence Type
- RNA expression
- source URLs
https://pubmed.ncbi.nlm.nih.gov/35427760/ · https://doi.org/10.1016/j.bbi.2022.04.003
- checked At
- 2026-10-23
- review Scope
- Publication abstract and selected full-text methods; Jadad assessment pending
Topics and recorded topic scores
- key
- language:mindfulness-rna
- title
- Mindfulness interventions and gene expression
- collection
- language
- trust Score
- 2
Citation snapshot and identifiers
- id
- pmid-35427760
- doi
- 10.1016/j.bbi.2022.04.003
- pmid
- 35427760
- citation Snapshot
- count
- 27
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1016/j.bbi.2022.04.003
- citations By Collection
- language
- 27
Complete approved library record
- id
- pmid-35427760
- publication Key
- Not recorded
- aliases
- None recorded
- title
- Smartphone mindfulness meditation training reduces Pro-inflammatory gene expression in stressed adults: A randomized controlled trial
- journal
- Brain, behavior, and immunity
- neurotransmitters
- None recorded
- year
- 2022
- authors
- Dutcher JM, Cole SW, Williams AC, Creswell JD.
- design
- Randomized controlled trial; registered single-blind (outcome assessors)
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1016/j.bbi.2022.04.003
- pmid
- 35427760
- urls
https://doi.org/10.1016/j.bbi.2022.04.003 · https://pubmed.ncbi.nlm.nih.gov/35427760/
- collections
language
- categories
Gene expression
- targets
- None recorded
- priority
- 0
- quotes
- None recorded
- summary
- Mindfulness training reduced inferred NF-κB activity relative to the active comparison programme. Stress decreased in both groups, without a significant difference between them.
- limitation
- The molecular result concerns an inferred transcription-control pathway. It does not establish a measured change in every NF-κB-related gene or a clinical treatment effect.
- citation Count
- 27
- citation Snapshot
- count
- 27
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1016/j.bbi.2022.04.003
- study Design Assessment
- basis
- The linked trial register specifies masked outcome assessors. The experimenter setting up the apps knew the assigned condition.
- sources
https://pubmed.ncbi.nlm.nih.gov/35427760/ · https://doi.org/10.1016/j.bbi.2022.04.003 · https://clinicaltrials.gov/study/NCT03803865 · https://www.healthandhumanperformancelab.com/_files/ugd/b30fc8_81ef3b38218542ec880d0700d6e1dec1.pdf
- assessed At
- 2026-10-23
- registered Masking Basis
- true
- category
- single-blind-rct
- peer Reviewed
- true
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- single
- peer Reviewed
- true
- basis
- The linked trial register specifies masked outcome assessors. The experimenter setting up the apps knew the assigned condition.
- sources
https://pubmed.ncbi.nlm.nih.gov/35427760/ · https://doi.org/10.1016/j.bbi.2022.04.003 · https://clinicaltrials.gov/study/NCT03803865 · https://www.healthandhumanperformancelab.com/_files/ugd/b30fc8_81ef3b38218542ec880d0700d6e1dec1.pdf
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- language
- 27
- topics
- key
- language:mindfulness-rna
- title
- Mindfulness interventions and gene expression
- collection
- language
- trust Score
- 2
- journal Key
- brainbehaviorandimmunity
- journal Label
- Brain, behavior, and immunity
- chapter Entries
- id
- language-mindfulness-rna-pmid-35427760
- record Id
- pmid-35427760
- title
- Smartphone mindfulness meditation training reduces Pro-inflammatory gene expression in stressed adults: A randomized controlled trial
- journal
- Brain, behavior, and immunity
- year
- 2022
- authors
- Dutcher JM, Cole SW, Williams AC, Creswell JD.
- design
- Randomized controlled trial; registered single-blind (outcome assessors)
- urls
https://doi.org/10.1016/j.bbi.2022.04.003 · https://pubmed.ncbi.nlm.nih.gov/35427760/
- quotes
- None recorded
- summary
- Mindfulness training reduced inferred NF-κB activity relative to the active comparison programme. Stress decreased in both groups, without a significant difference between them.
- limitation
- The molecular result concerns an inferred transcription-control pathway. It does not establish a measured change in every NF-κB-related gene or a clinical treatment effect.
- citation Count
- 27
- citation Snapshot
- count
- 27
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1016/j.bbi.2022.04.003
- study Design Assessment
- basis
- The linked trial register specifies masked outcome assessors. The experimenter setting up the apps knew the assigned condition.
- sources
https://pubmed.ncbi.nlm.nih.gov/35427760/ · https://doi.org/10.1016/j.bbi.2022.04.003 · https://clinicaltrials.gov/study/NCT03803865 · https://www.healthandhumanperformancelab.com/_files/ugd/b30fc8_81ef3b38218542ec880d0700d6e1dec1.pdf
- assessed At
- 2026-10-23
- registered Masking Basis
- true
- category
- single-blind-rct
- peer Reviewed
- true
- source Pages
- None recorded
- targets
- None recorded
- categories
Gene expression
- doi
- 10.1016/j.bbi.2022.04.003
- pmid
- 35427760
- evidence
- intervention
- Smartphone mindfulness meditation
- comparator
- Problem-solving programme
- sample
- Stressed customer-service workers
- measurement
- Immune-cell gene expression; promoter-based pathway analysis
- timing
- 30 days
- trial Id
- NCT03803865
- measured Genes
- None recorded
- pathways
NF-κB
- evidence Type
- RNA expression
- source URLs
https://pubmed.ncbi.nlm.nih.gov/35427760/ · https://doi.org/10.1016/j.bbi.2022.04.003
- checked At
- 2026-10-23
- review Scope
- Publication abstract and selected full-text methods; Jadad assessment pending
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- single
- peer Reviewed
- true
- basis
- The linked trial register specifies masked outcome assessors. The experimenter setting up the apps knew the assigned condition.
- sources
https://pubmed.ncbi.nlm.nih.gov/35427760/ · https://doi.org/10.1016/j.bbi.2022.04.003 · https://clinicaltrials.gov/study/NCT03803865 · https://www.healthandhumanperformancelab.com/_files/ugd/b30fc8_81ef3b38218542ec880d0700d6e1dec1.pdf
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- collection
- language
- chapter Number
- 4
- topic Id
- mindfulness-rna
- topic Title
- Mindfulness interventions and gene expression
- trust Score
- 2
- evidence
- intervention
- Smartphone mindfulness meditation
- comparator
- Problem-solving programme
- sample
- Stressed customer-service workers
- measurement
- Immune-cell gene expression; promoter-based pathway analysis
- timing
- 30 days
- trial Id
- NCT03803865
- measured Genes
- None recorded
- pathways
NF-κB
- evidence Type
- RNA expression
- source URLs
https://pubmed.ncbi.nlm.nih.gov/35427760/ · https://doi.org/10.1016/j.bbi.2022.04.003
- checked At
- 2026-10-23
- review Scope
- Publication abstract and selected full-text methods; Jadad assessment pending
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
2
- full Text
- status
- not-indexed
- retrieval Available
- false