Dopamine receptor signaling regulates fibrotic activation of retinal pigmented epithelial cells
Gao AY, Link PA, Bakri SJ, Haak AJ. · American journal of physiology. Cell physiology · 2022 · Human retinal pigment epithelial cell-line experiment
Original publication · Original publication
Recorded summary
DRD2 and DRD5 were prominent receptors in ARPE-19 cells. Dopamine-receptor manipulation altered profibrotic gene expression and cellular fibrosis measures.
Recorded limitations
Pharmacological receptor manipulation provides ocular pathway context. It is not a test of light or visual-stimulation effects on DRD2 expression.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Human retinal pigment epithelial cell-line experiment
- assessment
- Not recorded
- trust Factor
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/35544697/ · https://doi.org/10.1152/ajpcell.00468.2021
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- Not recorded
Topics and recorded topic scores
None recordedCitation snapshot and identifiers
- id
- pmid-35544697
- doi
- 10.1152/ajpcell.00468.2021
- pmid
- 35544697
- citation Snapshot
- Not recorded
- citations By Collection
- vision
- Not recorded
Complete approved library record
- id
- pmid-35544697
- publication Key
- Not recorded
- aliases
- None recorded
- title
- Dopamine receptor signaling regulates fibrotic activation of retinal pigmented epithelial cells
- journal
- American journal of physiology. Cell physiology
- neurotransmitters
- None recorded
- year
- 2022
- authors
- Gao AY, Link PA, Bakri SJ, Haak AJ.
- design
- Human retinal pigment epithelial cell-line experiment
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1152/ajpcell.00468.2021
- pmid
- 35544697
- urls
https://pubmed.ncbi.nlm.nih.gov/35544697/ · https://doi.org/10.1152/ajpcell.00468.2021
- collections
vision
- categories
Gene expression
- targets
DRD2
- priority
- 0
- quotes
- None recorded
- summary
- DRD2 and DRD5 were prominent receptors in ARPE-19 cells. Dopamine-receptor manipulation altered profibrotic gene expression and cellular fibrosis measures.
- limitation
- Pharmacological receptor manipulation provides ocular pathway context. It is not a test of light or visual-stimulation effects on DRD2 expression.
- citation Count
- Not recorded
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/35544697/ · https://doi.org/10.1152/ajpcell.00468.2021
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- vision
- Not recorded
- topics
- None recorded
- journal Key
- americanjournalofphysiologycellphysiology
- journal Label
- American journal of physiology. Cell physiology
- chapter Entries
- None recorded
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
- None recorded
- full Text
- status
- not-indexed
- retrieval Available
- false