Glial cell response to constant low light exposure in rat retina
Bruera MG, Benedetto MM, Guido ME, Degano AL, Contin MA. · Visual neuroscience · 2022 · Rat constant-light exposure experiment
Original publication · Original publication
Recorded summary
Prolonged constant low light was followed by retinal degeneration, glial activation and increased immune-mediator expression, including IL-6 and TNF.
Recorded limitations
This is a retinal-damage model. It does not establish that ordinary visual activity produces the same changes, or that increased expression is beneficial.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Rat constant-light exposure experiment
- assessment
- Not recorded
- trust Factor
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/36164752/ · https://doi.org/10.1017/s0952523822000049
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- Not recorded
Topics and recorded topic scores
None recordedCitation snapshot and identifiers
- id
- pmid-36164752
- doi
- 10.1017/s0952523822000049
- pmid
- 36164752
- citation Snapshot
- Not recorded
- citations By Collection
- vision
- Not recorded
Complete approved library record
- id
- pmid-36164752
- publication Key
- Not recorded
- aliases
- None recorded
- title
- Glial cell response to constant low light exposure in rat retina
- journal
- Visual neuroscience
- neurotransmitters
- None recorded
- year
- 2022
- authors
- Bruera MG, Benedetto MM, Guido ME, Degano AL, Contin MA.
- design
- Rat constant-light exposure experiment
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1017/s0952523822000049
- pmid
- 36164752
- urls
https://doi.org/10.1017/s0952523822000049 · https://pubmed.ncbi.nlm.nih.gov/36164752/
- collections
vision
- categories
Gene expression · Molecular biomarkers
- targets
IL6 · TNF
- priority
- 0
- quotes
- None recorded
- summary
- Prolonged constant low light was followed by retinal degeneration, glial activation and increased immune-mediator expression, including IL-6 and TNF.
- limitation
- This is a retinal-damage model. It does not establish that ordinary visual activity produces the same changes, or that increased expression is beneficial.
- citation Count
- Not recorded
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/36164752/ · https://doi.org/10.1017/s0952523822000049
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- vision
- Not recorded
- topics
- None recorded
- journal Key
- visualneuroscience
- journal Label
- Visual neuroscience
- chapter Entries
- None recorded
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
- None recorded
- full Text
- status
- not-indexed
- retrieval Available
- false