Potential epigenetic mechanisms in psychotherapy: a pilot study on DNA methylation and mentalization change in borderline personality disorder
Quevedo Y, Booij L, Herrera L, Hernández C, Jiménez JP. · Frontiers in Human Neuroscience · 2022 · Exploratory psychotherapy pilot
Original publication · Original publication
Recorded summary
FKBP5 methylation decreased over time, particularly among participants with early trauma who responded to psychotherapy.
Recorded limitations
A small uncontrolled pilot cannot establish causation. Confounding and the relationship between peripheral and brain measures remain unresolved.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Exploratory psychotherapy pilot
- assessment
- Not recorded
- trust Factor
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/36171872/ · https://doi.org/10.3389/fnhum.2022.955005
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- Not recorded
Topics and recorded topic scores
None recordedCitation snapshot and identifiers
- id
- pmid-36171872
- doi
- 10.3389/fnhum.2022.955005
- pmid
- 36171872
- citation Snapshot
- Not recorded
- citations By Collection
- language
- Not recorded
Complete approved library record
- id
- pmid-36171872
- publication Key
- Not recorded
- aliases
- None recorded
- title
- Potential epigenetic mechanisms in psychotherapy: a pilot study on DNA methylation and mentalization change in borderline personality disorder
- journal
- Frontiers in Human Neuroscience
- publisher Family
- frontiers
- publisher Family Label
- Frontiers
- neurotransmitters
- None recorded
- year
- 2022
- authors
- Quevedo Y, Booij L, Herrera L, Hernández C, Jiménez JP.
- design
- Exploratory psychotherapy pilot
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.3389/fnhum.2022.955005
- pmid
- 36171872
- urls
https://doi.org/10.3389/fnhum.2022.955005 · https://pubmed.ncbi.nlm.nih.gov/36171872/
- collections
language
- categories
Epigenetics
- targets
FKBP5
- priority
- 0
- quotes
- None recorded
- summary
- FKBP5 methylation decreased over time, particularly among participants with early trauma who responded to psychotherapy.
- limitation
- A small uncontrolled pilot cannot establish causation. Confounding and the relationship between peripheral and brain measures remain unresolved.
- citation Count
- Not recorded
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/36171872/ · https://doi.org/10.3389/fnhum.2022.955005
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- language
- Not recorded
- topics
- None recorded
- journal Key
- frontiersinhumanneuroscience
- journal Label
- Frontiers in Human Neuroscience
- chapter Entries
- None recorded
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
- None recorded
- full Text
- status
- open-license
- retrieval Available
- true
- url
- https://www.ebi.ac.uk/europepmc/webservices/rest/PMC9510615/fullTextXML
- pmcid
- PMC9510615
- rights
- license
- https://creativecommons.org/licenses/by/4.0/
- statement
Copyright © 2022 Quevedo, Booij, Herrera, Hernández and Jiménez. 2022 Quevedo, Booij, Herrera, Hernández and Jiménez https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- sha256
- 7ba29c44b2c048902e08a9bf517a33b232eb95cc15ac7b775e3f086661272427
- checked At
- 2026-10-24