Epigenetic impact of a 1-week intensive multimodal group program for adolescents with multiple adverse childhood experiences.
Kaliman P, Cosín-Tomás M, Madrid A, Roque López S, Llanez-Anaya E, Papale LA, Alisch RS, Davidson RJ. · Scientific Reports · 2022 · Randomized trial · molecular analysis
Original publication · Original publication · Original publication
Recorded summary
A one-week programme combining mindfulness, artistic expression and EMDR group therapy studied 44 adolescent girls with multiple adverse experiences. Forty-nine DNA-methylation loci differed with intervention; SIRT5 and TRAPPC2L changes correlated with trauma measures.
Recorded limitations
The programme has several components. Saliva methylation findings do not isolate EMDR; the study detected no intervention effect on intrinsic epigenetic age acceleration.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Randomized trial · molecular analysis
- assessment
- category
- rct-masking-unclear
- peer Reviewed
- true
- basis
- The methods report random-number allocation for 44 girls. Post-allocation participant or assessor masking is not established. The intervention combines mindfulness, art and group EMDR.
- sources
https://pubmed.ncbi.nlm.nih.gov/36266402/ · https://doi.org/10.1038/s41598-022-21246-9
- reviewed At
- 2026-10-23
- trust Factor
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- The methods report random-number allocation for 44 girls. Post-allocation participant or assessor masking is not established. The intervention combines mindfulness, art and group EMDR.
- sources
https://pubmed.ncbi.nlm.nih.gov/36266402/ · https://doi.org/10.1038/s41598-022-21246-9
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- evidence Type
- Epigenetics
- measured Genes
SIRT5 · TRAPPC2L
- relationship Note
- The programme has several components. Saliva methylation findings do not isolate EMDR; the study detected no intervention effect on intrinsic epigenetic age acceleration.
Topics and recorded topic scores
- key
- vision:epigenetics
- title
- EMDR and trauma-focused psychotherapy: DNA methylation
- collection
- vision
- trust Score
- 1
Citation snapshot and identifiers
- id
- pmid-36266402
- doi
- 10.1038/s41598-022-21246-9
- pmid
- 36266402
- citation Snapshot
- count
- 24
- source
- Crossref
- retrieved At
- 2026-10-23
- citations By Collection
- vision
- 24
Complete approved library record
- id
- pmid-36266402
- publication Key
- doi:10.1038/s41598-022-21246-9
- aliases
- None recorded
- title
- Epigenetic impact of a 1-week intensive multimodal group program for adolescents with multiple adverse childhood experiences.
- journal
- Scientific Reports
- publisher Family
- nature
- publisher Family Label
- Nature Portfolio
- neurotransmitters
- None recorded
- year
- 2022
- authors
- Kaliman P, Cosín-Tomás M, Madrid A, Roque López S, Llanez-Anaya E, Papale LA, Alisch RS, Davidson RJ.
- design
- Randomized trial · molecular analysis
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1038/s41598-022-21246-9
- pmid
- 36266402
- urls
https://pmc.ncbi.nlm.nih.gov/articles/PMC9585146/ · https://pubmed.ncbi.nlm.nih.gov/36266402/ · https://doi.org/10.1038/s41598-022-21246-9
- collections
vision
- categories
Epigenetics · Clinical & self-report
- targets
SIRT5 · TRAPPC2L
- priority
- 0
- quotes
- None recorded
- summary
- A one-week programme combining mindfulness, artistic expression and EMDR group therapy studied 44 adolescent girls with multiple adverse experiences. Forty-nine DNA-methylation loci differed with intervention; SIRT5 and TRAPPC2L changes correlated with trauma measures.
- limitation
- The programme has several components. Saliva methylation findings do not isolate EMDR; the study detected no intervention effect on intrinsic epigenetic age acceleration.
- citation Count
- 24
- citation Snapshot
- count
- 24
- source
- Crossref
- retrieved At
- 2026-10-23
- study Design Assessment
- category
- rct-masking-unclear
- peer Reviewed
- true
- basis
- The methods report random-number allocation for 44 girls. Post-allocation participant or assessor masking is not established. The intervention combines mindfulness, art and group EMDR.
- sources
https://pubmed.ncbi.nlm.nih.gov/36266402/ · https://doi.org/10.1038/s41598-022-21246-9
- reviewed At
- 2026-10-23
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- The methods report random-number allocation for 44 girls. Post-allocation participant or assessor masking is not established. The intervention combines mindfulness, art and group EMDR.
- sources
https://pubmed.ncbi.nlm.nih.gov/36266402/ · https://doi.org/10.1038/s41598-022-21246-9
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- vision
- 24
- topics
- key
- vision:epigenetics
- title
- EMDR and trauma-focused psychotherapy: DNA methylation
- collection
- vision
- trust Score
- 1
- journal Key
- scientificreports
- journal Label
- Scientific Reports
- chapter Entries
- title
- Epigenetic impact of a 1-week intensive multimodal group program for adolescents with multiple adverse childhood experiences.
- journal
- Scientific Reports
- year
- 2022
- authors
- Kaliman P, Cosín-Tomás M, Madrid A, Roque López S, Llanez-Anaya E, Papale LA, Alisch RS, Davidson RJ.
- design
- Randomized trial · molecular analysis
- urls
https://pmc.ncbi.nlm.nih.gov/articles/PMC9585146/ · https://pubmed.ncbi.nlm.nih.gov/36266402/ · https://doi.org/10.1038/s41598-022-21246-9
- doi
- 10.1038/s41598-022-21246-9
- pmid
- 36266402
- targets
SIRT5 · TRAPPC2L
- categories
Epigenetics · Clinical & self-report
- citation Count
- 24
- citation Snapshot
- count
- 24
- source
- Crossref
- retrieved At
- 2026-10-23
- study Design Assessment
- category
- rct-masking-unclear
- peer Reviewed
- true
- basis
- The methods report random-number allocation for 44 girls. Post-allocation participant or assessor masking is not established. The intervention combines mindfulness, art and group EMDR.
- sources
https://pubmed.ncbi.nlm.nih.gov/36266402/ · https://doi.org/10.1038/s41598-022-21246-9
- reviewed At
- 2026-10-23
- evidence
- evidence Type
- Epigenetics
- measured Genes
SIRT5 · TRAPPC2L
- relationship Note
- The programme has several components. Saliva methylation findings do not isolate EMDR; the study detected no intervention effect on intrinsic epigenetic age acceleration.
- record Id
- pmid-36266402
- quotes
- None recorded
- source Pages
- None recorded
- summary
- A one-week programme combining mindfulness, artistic expression and EMDR group therapy studied 44 adolescent girls with multiple adverse experiences. Forty-nine DNA-methylation loci differed with intervention; SIRT5 and TRAPPC2L changes correlated with trauma measures.
- limitation
- The programme has several components. Saliva methylation findings do not isolate EMDR; the study detected no intervention effect on intrinsic epigenetic age acceleration.
- id
- vision-epigenetics-pmid-36266402
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- The methods report random-number allocation for 44 girls. Post-allocation participant or assessor masking is not established. The intervention combines mindfulness, art and group EMDR.
- sources
https://pubmed.ncbi.nlm.nih.gov/36266402/ · https://doi.org/10.1038/s41598-022-21246-9
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- publication Key
- doi:10.1038/s41598-022-21246-9
- collection
- vision
- chapter Number
- 4
- topic Id
- epigenetics
- topic Title
- EMDR and trauma-focused psychotherapy: DNA methylation
- trust Score
- 1
- evidence
- evidence Type
- Epigenetics
- measured Genes
SIRT5 · TRAPPC2L
- relationship Note
- The programme has several components. Saliva methylation findings do not isolate EMDR; the study detected no intervention effect on intrinsic epigenetic age acceleration.
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
1
- full Text
- status
- open-license
- retrieval Available
- true
- url
- https://www.ebi.ac.uk/europepmc/webservices/rest/PMC9585146/fullTextXML
- pmcid
- PMC9585146
- rights
- license
- https://creativecommons.org/licenses/by/4.0/
- statement
© The Author(s) 2022 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ .
- sha256
- 0607c4228978f1d5cecc9a83ea9c2cb2cc3f31ed7f5fdc80abeb6a460e2eafcc
- checked At
- 2026-10-24