Online, low-volume meditation does not alter immune-related biomarkers
Graham B, Jin Y, Bazeley P, Husni E, Calabrese LH. · Brain, behavior, & immunity - health · 2022 · Randomized pilot trial; single-blind
Original publication · Original publication
Recorded summary
The trial found no significant between-group differences in the prespecified immune-related gene set, wider RNA expression or other tested biomarkers. Stress improved earlier in the music group and later in the mindfulness group.
Recorded limitations
A small trial of brief online practice in otherwise healthy nurses. The result concerns this dose and delivery; it does not establish the absence of effects from other programmes.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Randomized pilot trial; single-blind
- assessment
- basis
- The Methods section explicitly describes a single-blind randomized parallel pilot trial.
- sources
https://pmc.ncbi.nlm.nih.gov/articles/PMC9576541/ · https://pubmed.ncbi.nlm.nih.gov/36267832/ · https://doi.org/10.1016/j.bbih.2022.100531
- assessed At
- 2026-10-23
- registered Masking Basis
- false
- category
- single-blind-rct
- peer Reviewed
- true
- trust Factor
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- single
- peer Reviewed
- true
- basis
- The Methods section explicitly describes a single-blind randomized parallel pilot trial.
- sources
https://pubmed.ncbi.nlm.nih.gov/36267832/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC9576541/ · https://doi.org/10.1016/j.bbih.2022.100531
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- intervention
- Online mindfulness-based stress management
- comparator
- Relaxing music
- sample
- 61 nurses randomized; 52 included in analysis
- measurement
- Whole-blood mRNA sequencing; cytokines; PBMC telomerase; salivary cortisol
- timing
- 6 weeks; questionnaires through 12 weeks
- trial Id
- Not recorded
- measured Genes
- None recorded
- pathways
CTRA
- evidence Type
- RNA expression
- source URLs
https://pmc.ncbi.nlm.nih.gov/articles/PMC9576541/ · https://pubmed.ncbi.nlm.nih.gov/36267832/ · https://doi.org/10.1016/j.bbih.2022.100531
- checked At
- 2026-10-23
- review Scope
- Publication abstract and selected full-text methods; Jadad assessment pending
Topics and recorded topic scores
- key
- language:mindfulness-rna
- title
- Mindfulness interventions and gene expression
- collection
- language
- trust Score
- 2
Citation snapshot and identifiers
- id
- pmid-36267832
- doi
- 10.1016/j.bbih.2022.100531
- pmid
- 36267832
- citation Snapshot
- count
- 10
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1016/j.bbih.2022.100531
- citations By Collection
- language
- 10
- sound
- Not recorded
Complete approved library record
- id
- pmid-36267832
- publication Key
- Not recorded
- aliases
- None recorded
- title
- Online, low-volume meditation does not alter immune-related biomarkers
- journal
- Brain, behavior, & immunity - health
- neurotransmitters
- None recorded
- year
- 2022
- authors
- Graham B, Jin Y, Bazeley P, Husni E, Calabrese LH.
- design
- Randomized pilot trial; single-blind
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1016/j.bbih.2022.100531
- pmid
- 36267832
- urls
https://doi.org/10.1016/j.bbih.2022.100531 · https://pubmed.ncbi.nlm.nih.gov/36267832/
- collections
language · sound
- categories
Gene expression
- targets
- None recorded
- priority
- 0
- quotes
- None recorded
- summary
- The trial found no significant between-group differences in the prespecified immune-related gene set, wider RNA expression or other tested biomarkers. Stress improved earlier in the music group and later in the mindfulness group.
- limitation
- A small trial of brief online practice in otherwise healthy nurses. The result concerns this dose and delivery; it does not establish the absence of effects from other programmes.
- citation Count
- 10
- citation Snapshot
- count
- 10
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1016/j.bbih.2022.100531
- study Design Assessment
- basis
- The Methods section explicitly describes a single-blind randomized parallel pilot trial.
- sources
https://pmc.ncbi.nlm.nih.gov/articles/PMC9576541/ · https://pubmed.ncbi.nlm.nih.gov/36267832/ · https://doi.org/10.1016/j.bbih.2022.100531
- assessed At
- 2026-10-23
- registered Masking Basis
- false
- category
- single-blind-rct
- peer Reviewed
- true
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- single
- peer Reviewed
- true
- basis
- The Methods section explicitly describes a single-blind randomized parallel pilot trial.
- sources
https://pubmed.ncbi.nlm.nih.gov/36267832/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC9576541/ · https://doi.org/10.1016/j.bbih.2022.100531
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- language
- 10
- sound
- Not recorded
- topics
- key
- language:mindfulness-rna
- title
- Mindfulness interventions and gene expression
- collection
- language
- trust Score
- 2
- journal Key
- brainbehaviorandimmunityhealth
- journal Label
- Brain, behavior, & immunity - health
- chapter Entries
- id
- language-mindfulness-rna-pmid-36267832
- record Id
- pmid-36267832
- title
- Online, low-volume meditation does not alter immune-related biomarkers
- journal
- Brain, behavior, & immunity - health
- year
- 2022
- authors
- Graham B, Jin Y, Bazeley P, Husni E, Calabrese LH.
- design
- Randomized pilot trial; single-blind
- urls
https://doi.org/10.1016/j.bbih.2022.100531 · https://pubmed.ncbi.nlm.nih.gov/36267832/
- quotes
- None recorded
- summary
- The trial found no significant between-group differences in the prespecified immune-related gene set, wider RNA expression or other tested biomarkers. Stress improved earlier in the music group and later in the mindfulness group.
- limitation
- A small trial of brief online practice in otherwise healthy nurses. The result concerns this dose and delivery; it does not establish the absence of effects from other programmes.
- citation Count
- 10
- citation Snapshot
- count
- 10
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1016/j.bbih.2022.100531
- study Design Assessment
- basis
- The Methods section explicitly describes a single-blind randomized parallel pilot trial.
- sources
https://pmc.ncbi.nlm.nih.gov/articles/PMC9576541/ · https://pubmed.ncbi.nlm.nih.gov/36267832/ · https://doi.org/10.1016/j.bbih.2022.100531
- assessed At
- 2026-10-23
- registered Masking Basis
- false
- category
- single-blind-rct
- peer Reviewed
- true
- source Pages
- None recorded
- targets
- None recorded
- categories
Gene expression
- doi
- 10.1016/j.bbih.2022.100531
- pmid
- 36267832
- evidence
- intervention
- Online mindfulness-based stress management
- comparator
- Relaxing music
- sample
- 61 nurses randomized; 52 included in analysis
- measurement
- Whole-blood mRNA sequencing; cytokines; PBMC telomerase; salivary cortisol
- timing
- 6 weeks; questionnaires through 12 weeks
- trial Id
- Not recorded
- measured Genes
- None recorded
- pathways
CTRA
- evidence Type
- RNA expression
- source URLs
https://pmc.ncbi.nlm.nih.gov/articles/PMC9576541/ · https://pubmed.ncbi.nlm.nih.gov/36267832/ · https://doi.org/10.1016/j.bbih.2022.100531
- checked At
- 2026-10-23
- review Scope
- Publication abstract and selected full-text methods; Jadad assessment pending
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- single
- peer Reviewed
- true
- basis
- The Methods section explicitly describes a single-blind randomized parallel pilot trial.
- sources
https://pubmed.ncbi.nlm.nih.gov/36267832/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC9576541/ · https://doi.org/10.1016/j.bbih.2022.100531
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- collection
- language
- chapter Number
- 4
- topic Id
- mindfulness-rna
- topic Title
- Mindfulness interventions and gene expression
- trust Score
- 2
- evidence
- intervention
- Online mindfulness-based stress management
- comparator
- Relaxing music
- sample
- 61 nurses randomized; 52 included in analysis
- measurement
- Whole-blood mRNA sequencing; cytokines; PBMC telomerase; salivary cortisol
- timing
- 6 weeks; questionnaires through 12 weeks
- trial Id
- Not recorded
- measured Genes
- None recorded
- pathways
CTRA
- evidence Type
- RNA expression
- source URLs
https://pmc.ncbi.nlm.nih.gov/articles/PMC9576541/ · https://pubmed.ncbi.nlm.nih.gov/36267832/ · https://doi.org/10.1016/j.bbih.2022.100531
- checked At
- 2026-10-23
- review Scope
- Publication abstract and selected full-text methods; Jadad assessment pending
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
2
- full Text
- status
- not-indexed
- retrieval Available
- false