Mindfulness-Based Stress Reduction vs Escitalopram for the Treatment of Adults With Anxiety Disorders: A Randomized Clinical Trial
Hoge EA, Bui E, Mete M, Dutton MA, Baker AW, Simon NM. · JAMA psychiatry · 2023 · Randomized controlled trial; single-blind (clinical assessors)
Original publication · Original publication · Original publication
Recorded summary
MBSR met the prespecified noninferiority criterion against escitalopram for anxiety severity at eight weeks. Mean CGI-S improvement was 1.35 points with MBSR and 1.43 with escitalopram.
Recorded limitations
This result applies to a structured, teacher-led MBSR course and the trial’s noninferiority margin. It is not a test of an app or gene expression.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Randomized controlled trial; single-blind (clinical assessors)
- assessment
- basis
- The article identifies a single-blind trial: independent clinical evaluators were masked, while participants and providers knew the treatment.
- sources
https://pmc.ncbi.nlm.nih.gov/articles/PMC9647561/ · https://pubmed.ncbi.nlm.nih.gov/36350591/ · https://doi.org/10.1001/jamapsychiatry.2022.3679 · https://clinicaltrials.gov/study/NCT03522844
- assessed At
- 2026-10-23
- registered Masking Basis
- false
- category
- single-blind-rct
- peer Reviewed
- true
- trust Factor
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- single
- peer Reviewed
- true
- basis
- The article identifies a single-blind trial: independent clinical evaluators were masked, while participants and providers knew the treatment.
- sources
https://pubmed.ncbi.nlm.nih.gov/36350591/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC9647561/ · https://doi.org/10.1001/jamapsychiatry.2022.3679 · https://clinicaltrials.gov/study/NCT03522844
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- intervention
- MBSR
- comparator
- Escitalopram
- sample
- 276 adults randomized; 208 in the primary per-protocol analysis
- measurement
- Clinician-rated anxiety severity
- timing
- 8-week primary endpoint; follow-up to 24 weeks
- trial Id
- NCT03522844
- measured Genes
- None recorded
- pathways
- None recorded
- evidence Type
- Clinical outcomes
- source URLs
https://pmc.ncbi.nlm.nih.gov/articles/PMC9647561/ · https://pubmed.ncbi.nlm.nih.gov/36350591/ · https://doi.org/10.1001/jamapsychiatry.2022.3679
- checked At
- 2026-10-23
- review Scope
- Publication abstract and selected full-text methods; Jadad assessment pending
Topics and recorded topic scores
- key
- language:mindfulness-clinical
- title
- Mindfulness-based interventions: controlled clinical trials
- collection
- language
- trust Score
- 2
Citation snapshot and identifiers
- id
- pmid-36350591
- doi
- 10.1001/jamapsychiatry.2022.3679
- pmid
- 36350591
- citation Snapshot
- count
- 184
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1001/jamapsychiatry.2022.3679
- citations By Collection
- language
- 184
Complete approved library record
- id
- pmid-36350591
- aliases
- None recorded
- title
- Mindfulness-Based Stress Reduction vs Escitalopram for the Treatment of Adults With Anxiety Disorders: A Randomized Clinical Trial
- journal
- JAMA psychiatry
- neurotransmitters
- None recorded
- year
- 2023
- authors
- Hoge EA, Bui E, Mete M, Dutton MA, Baker AW, Simon NM.
- design
- Randomized controlled trial; single-blind (clinical assessors)
- identity Conflict
- Not recorded
- doi
- 10.1001/jamapsychiatry.2022.3679
- pmid
- 36350591
- urls
https://pmc.ncbi.nlm.nih.gov/articles/PMC9647561/ · https://pubmed.ncbi.nlm.nih.gov/36350591/ · https://doi.org/10.1001/jamapsychiatry.2022.3679
- collections
language
- categories
Clinical & self-report
- targets
- None recorded
- priority
- 1
- quotes
- None recorded
- summary
- MBSR met the prespecified noninferiority criterion against escitalopram for anxiety severity at eight weeks. Mean CGI-S improvement was 1.35 points with MBSR and 1.43 with escitalopram.
- limitation
- This result applies to a structured, teacher-led MBSR course and the trial’s noninferiority margin. It is not a test of an app or gene expression.
- citation Count
- 184
- citation Snapshot
- count
- 184
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1001/jamapsychiatry.2022.3679
- study Design Assessment
- basis
- The article identifies a single-blind trial: independent clinical evaluators were masked, while participants and providers knew the treatment.
- sources
https://pmc.ncbi.nlm.nih.gov/articles/PMC9647561/ · https://pubmed.ncbi.nlm.nih.gov/36350591/ · https://doi.org/10.1001/jamapsychiatry.2022.3679 · https://clinicaltrials.gov/study/NCT03522844
- assessed At
- 2026-10-23
- registered Masking Basis
- false
- category
- single-blind-rct
- peer Reviewed
- true
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- single
- peer Reviewed
- true
- basis
- The article identifies a single-blind trial: independent clinical evaluators were masked, while participants and providers knew the treatment.
- sources
https://pubmed.ncbi.nlm.nih.gov/36350591/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC9647561/ · https://doi.org/10.1001/jamapsychiatry.2022.3679 · https://clinicaltrials.gov/study/NCT03522844
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- language
- 184
- topics
- key
- language:mindfulness-clinical
- title
- Mindfulness-based interventions: controlled clinical trials
- collection
- language
- trust Score
- 2
- journal Key
- jamapsychiatry
- journal Label
- JAMA psychiatry
- chapter Entries
- id
- language-mindfulness-clinical-pmid-36350591
- record Id
- pmid-36350591
- title
- Mindfulness-Based Stress Reduction vs Escitalopram for the Treatment of Adults With Anxiety Disorders: A Randomized Clinical Trial
- journal
- JAMA psychiatry
- year
- 2023
- authors
- Hoge EA, Bui E, Mete M, Dutton MA, Baker AW, Simon NM.
- design
- Randomized controlled trial; single-blind (clinical assessors)
- urls
https://pmc.ncbi.nlm.nih.gov/articles/PMC9647561/ · https://pubmed.ncbi.nlm.nih.gov/36350591/ · https://doi.org/10.1001/jamapsychiatry.2022.3679
- quotes
- None recorded
- summary
- MBSR met the prespecified noninferiority criterion against escitalopram for anxiety severity at eight weeks. Mean CGI-S improvement was 1.35 points with MBSR and 1.43 with escitalopram.
- limitation
- This result applies to a structured, teacher-led MBSR course and the trial’s noninferiority margin. It is not a test of an app or gene expression.
- citation Count
- 184
- citation Snapshot
- count
- 184
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1001/jamapsychiatry.2022.3679
- study Design Assessment
- basis
- The article identifies a single-blind trial: independent clinical evaluators were masked, while participants and providers knew the treatment.
- sources
https://pmc.ncbi.nlm.nih.gov/articles/PMC9647561/ · https://pubmed.ncbi.nlm.nih.gov/36350591/ · https://doi.org/10.1001/jamapsychiatry.2022.3679 · https://clinicaltrials.gov/study/NCT03522844
- assessed At
- 2026-10-23
- registered Masking Basis
- false
- category
- single-blind-rct
- peer Reviewed
- true
- source Pages
- None recorded
- targets
- None recorded
- categories
Clinical & self-report
- doi
- 10.1001/jamapsychiatry.2022.3679
- pmid
- 36350591
- evidence
- intervention
- MBSR
- comparator
- Escitalopram
- sample
- 276 adults randomized; 208 in the primary per-protocol analysis
- measurement
- Clinician-rated anxiety severity
- timing
- 8-week primary endpoint; follow-up to 24 weeks
- trial Id
- NCT03522844
- measured Genes
- None recorded
- pathways
- None recorded
- evidence Type
- Clinical outcomes
- source URLs
https://pmc.ncbi.nlm.nih.gov/articles/PMC9647561/ · https://pubmed.ncbi.nlm.nih.gov/36350591/ · https://doi.org/10.1001/jamapsychiatry.2022.3679
- checked At
- 2026-10-23
- review Scope
- Publication abstract and selected full-text methods; Jadad assessment pending
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- single
- peer Reviewed
- true
- basis
- The article identifies a single-blind trial: independent clinical evaluators were masked, while participants and providers knew the treatment.
- sources
https://pubmed.ncbi.nlm.nih.gov/36350591/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC9647561/ · https://doi.org/10.1001/jamapsychiatry.2022.3679 · https://clinicaltrials.gov/study/NCT03522844
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- collection
- language
- chapter Number
- 4
- topic Id
- mindfulness-clinical
- topic Title
- Mindfulness-based interventions: controlled clinical trials
- trust Score
- 2
- evidence
- intervention
- MBSR
- comparator
- Escitalopram
- sample
- 276 adults randomized; 208 in the primary per-protocol analysis
- measurement
- Clinician-rated anxiety severity
- timing
- 8-week primary endpoint; follow-up to 24 weeks
- trial Id
- NCT03522844
- measured Genes
- None recorded
- pathways
- None recorded
- evidence Type
- Clinical outcomes
- source URLs
https://pmc.ncbi.nlm.nih.gov/articles/PMC9647561/ · https://pubmed.ncbi.nlm.nih.gov/36350591/ · https://doi.org/10.1001/jamapsychiatry.2022.3679
- checked At
- 2026-10-23
- review Scope
- Publication abstract and selected full-text methods; Jadad assessment pending
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- id
- anxiety
- evidence
- field
- title
- text
- Mindfulness-Based Stress Reduction vs Escitalopram for the Treatment of Adults With Anxiety Disorders: A Randomized Clinical Trial
- matched Text
- Anxiety
- field
- evidence.measurement
- text
- Clinician-rated anxiety severity
- matched Text
- anxiety
- conditions
anxiety
- topic Trust Scores
2
- full Text
- status
- not-indexed
- retrieval Available
- false