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The oxytocin receptor represents a key hub in the GPCR heteroreceptor network: potential relevance for brain and behavior

Borroto-Escuela DO, Cuesta-Marti C, Lopez-Salas A, Chruścicka-Smaga B, Crespo-Ramírez M, Tesoro-Cruz E, Palacios-Lagunas DA, Perez de la Mora M, Schellekens H, Fuxe K. · Frontiers in Molecular Neuroscience · 2022 · Narrative review of receptor-complex studies

Original publication · Original publication

Recorded summary

The review describes OXTR-containing receptor complexes, including dopamine D2 receptor–OXTR complexes reported in rat striatal regions, and discusses potential functional consequences for behaviour.

Recorded limitations

Receptor complex formation and signalling do not establish human DRD2 transcriptional regulation. This review does not test sensory interventions, the Fibonacci hypothesis or all proposed target relationships.

Evidence and provenance

Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.

Study design and assessment
design
Narrative review of receptor-complex studies
assessment
Not recorded
trust Factor
score
1
scope
Paper
status
assessed
randomized Controlled Trial
false
blinding
not-applicable
peer Reviewed
true
basis
Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
sources

https://pubmed.ncbi.nlm.nih.gov/36618821/ · https://doi.org/10.3389/fnmol.2022.1055344

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
jadad
status
unassessed
score
Not recorded
evidence
Not recorded
Topics and recorded topic scores
  1. key
    general:optical-physiology
    title
    Optical Physiology and Tissue Imaging
    collection
    general
    trust Score
    Not recorded
Citation snapshot and identifiers
id
pmid-36618821
doi
10.3389/fnmol.2022.1055344
pmid
36618821
citation Snapshot
Not recorded
citations By Collection
sound
Not recorded
vision
Not recorded
language
Not recorded
general
Not recorded
Complete approved library record
id
pmid-36618821
publication Key
Not recorded
aliases
None recorded
source References
  1. ref
    NPL-29
    record Id
    pmid-36618821
    source Type
    Review
    title
    The oxytocin receptor represents a key hub in the GPCR heteroreceptor network: potential relevance for brain and behavior.
    authors
    Borroto-Escuela DO, Cuesta-Marti C, Lopez-Salas A, Chruścicka-Smaga B, Crespo-Ramírez M, Tesoro-Cruz E, Palacios-Lagunas DA, Perez de la Mora M, Schellekens H, Fuxe K.
    year
    2022
    journal
    Frontiers in molecular neuroscience
    doi
    10.3389/fnmol.2022.1055344
    pmid
    36618821
    pmcid
    PMC9812438
    patent Number
    Not recorded
    original Assignee
    Not recorded
    original Citation
    Busnelli M, Bhatt S (2022). "The oxytocin receptor represents a key hub in the GPCR signaling network." Frontiers in Endocrinology (PMC 9812438)
    original Section
    OXTR Influence on Facial Microcirculation
    metadata Status
    metadata-reconciled
    claim Review
    Not independently appraised
    source URL
    https://www.notion.so/3807b9c99c5680599be7d8337c817b15
    publication URL
    https://pubmed.ncbi.nlm.nih.gov/36618821/
    metadata URL
    https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.3389%2Ffnmol.2022.1055344%22&format=json&resultType=core&pageSize=4
    corrections

    Canonical title, authors, year and identifiers follow the linked public metadata record. The original citation is retained for comparison. · Published title reconciled with the metadata record. · Author attribution differs from the public metadata; canonical authors are shown in source details.

    topic Id
    optical-physiology
    role
    Focused chapter source
source Type
Review
source Verification
Bibliographic metadata matched; scientific claims await appraisal.
source Collection
Hyperspectral Imaging · patent section 2.4
title
The oxytocin receptor represents a key hub in the GPCR heteroreceptor network: potential relevance for brain and behavior
journal
Frontiers in Molecular Neuroscience
publisher Family
frontiers
publisher Family Label
Frontiers
neurotransmitters
None recorded
year
2022
authors
Borroto-Escuela DO, Cuesta-Marti C, Lopez-Salas A, Chruścicka-Smaga B, Crespo-Ramírez M, Tesoro-Cruz E, Palacios-Lagunas DA, Perez de la Mora M, Schellekens H, Fuxe K.
design
Narrative review of receptor-complex studies
kind
Review / synthesis
identity Conflict
Not recorded
doi
10.3389/fnmol.2022.1055344
pmid
36618821
urls

https://doi.org/10.3389/fnmol.2022.1055344 · https://pubmed.ncbi.nlm.nih.gov/36618821/

collections

sound · vision · language · general

categories

Molecular biomarkers · Methods & context

targets

OXTR · OXT · DRD2

priority
1
quotes
None recorded
summary
The review describes OXTR-containing receptor complexes, including dopamine D2 receptor–OXTR complexes reported in rat striatal regions, and discusses potential functional consequences for behaviour.
limitation
Receptor complex formation and signalling do not establish human DRD2 transcriptional regulation. This review does not test sensory interventions, the Fibonacci hypothesis or all proposed target relationships.
citation Count
Not recorded
paper Trust Assessment
score
1
scope
Paper
status
assessed
randomized Controlled Trial
false
blinding
not-applicable
peer Reviewed
true
basis
Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
sources

https://pubmed.ncbi.nlm.nih.gov/36618821/ · https://doi.org/10.3389/fnmol.2022.1055344

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
citations By Collection
sound
Not recorded
vision
Not recorded
language
Not recorded
general
Not recorded
topics
  1. key
    general:optical-physiology
    title
    Optical Physiology and Tissue Imaging
    collection
    general
    trust Score
    Not recorded
journal Key
frontiersinmolecularneuroscience
journal Label
Frontiers in Molecular Neuroscience
chapter Entries
  1. id
    general-optical-physiology-pmid-36618821
    record Id
    pmid-36618821
    title
    The oxytocin receptor represents a key hub in the GPCR heteroreceptor network: potential relevance for brain and behavior
    journal
    Frontiers in Molecular Neuroscience
    year
    2022
    authors
    Borroto-Escuela DO, Cuesta-Marti C, Lopez-Salas A, Chruścicka-Smaga B, Crespo-Ramírez M, Tesoro-Cruz E, Palacios-Lagunas DA, Perez de la Mora M, Schellekens H, Fuxe K.
    design
    Narrative review of receptor-complex studies
    urls

    https://doi.org/10.3389/fnmol.2022.1055344 · https://pubmed.ncbi.nlm.nih.gov/36618821/

    quotes
    None recorded
    summary
    The review describes OXTR-containing receptor complexes, including dopamine D2 receptor–OXTR complexes reported in rat striatal regions, and discusses potential functional consequences for behaviour.
    related Versions
    None recorded
    limitation
    Receptor complex formation and signalling do not establish human DRD2 transcriptional regulation. This review does not test sensory interventions, the Fibonacci hypothesis or all proposed target relationships.
    citation Count
    Not recorded
    source Pages
    None recorded
    doi
    10.3389/fnmol.2022.1055344
    pmid
    36618821
    targets

    OXTR · OXT · DRD2

    categories

    Molecular biomarkers · Methods & context

    source References
    1. ref
      NPL-29
      record Id
      pmid-36618821
      source Type
      Review
      title
      The oxytocin receptor represents a key hub in the GPCR heteroreceptor network: potential relevance for brain and behavior.
      authors
      Borroto-Escuela DO, Cuesta-Marti C, Lopez-Salas A, Chruścicka-Smaga B, Crespo-Ramírez M, Tesoro-Cruz E, Palacios-Lagunas DA, Perez de la Mora M, Schellekens H, Fuxe K.
      year
      2022
      journal
      Frontiers in molecular neuroscience
      doi
      10.3389/fnmol.2022.1055344
      pmid
      36618821
      pmcid
      PMC9812438
      patent Number
      Not recorded
      original Assignee
      Not recorded
      original Citation
      Busnelli M, Bhatt S (2022). "The oxytocin receptor represents a key hub in the GPCR signaling network." Frontiers in Endocrinology (PMC 9812438)
      original Section
      OXTR Influence on Facial Microcirculation
      metadata Status
      metadata-reconciled
      claim Review
      Not independently appraised
      source URL
      https://www.notion.so/3807b9c99c5680599be7d8337c817b15
      publication URL
      https://pubmed.ncbi.nlm.nih.gov/36618821/
      metadata URL
      https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI%3A%2210.3389%2Ffnmol.2022.1055344%22&format=json&resultType=core&pageSize=4
      corrections

      Canonical title, authors, year and identifiers follow the linked public metadata record. The original citation is retained for comparison. · Published title reconciled with the metadata record. · Author attribution differs from the public metadata; canonical authors are shown in source details.

      topic Id
      optical-physiology
      role
      Focused chapter source
    source Type
    Review
    source Verification
    Bibliographic metadata matched; scientific claims await appraisal.
    collection
    general
    chapter Number
    11
    topic Id
    optical-physiology
    topic Title
    Optical Physiology and Tissue Imaging
    trust Score
    Not recorded
    paper Trust Assessment
    score
    1
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    false
    blinding
    not-applicable
    peer Reviewed
    true
    basis
    Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
    sources

    https://pubmed.ncbi.nlm.nih.gov/36618821/ · https://doi.org/10.3389/fnmol.2022.1055344

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
jadad
status
unassessed
score
Not recorded
condition Evidence
None recorded
conditions
None recorded
topic Trust Scores
None recorded
full Text
status
open-license
retrieval Available
true
url
https://www.ebi.ac.uk/europepmc/webservices/rest/PMC9812438/fullTextXML
pmcid
PMC9812438
rights
license
CC BY (version not specified in article)
statement

Copyright © 2022 Borroto-Escuela, Cuesta-Marti, Lopez-Salas, Chruścicka-Smaga, Crespo-Ramírez, Tesoro-Cruz, Palacios-Lagunas, Perez de la Mora, Schellekens and Fuxe. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

sha256
cb16595aca7bdb54e723aa7040a7209d2183db43bd4a643feb2b9231a1611700
checked At
2026-10-24

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