Epigenetics of traumatic stress: The association of NR3C1 methylation and posttraumatic stress disorder symptom changes in response to narrative exposure therapy
Wilker S, Vukojevic V, Schneider A, Pfeiffer A, Inerle S, Pauly M, Elbert T, Papassotiropoulos A, de Quervain D, Kolassa IT. · Translational Psychiatry · 2023 · Longitudinal psychotherapy cohort
Original publication · Original publication
Recorded summary
Change at NR3C1 CpG cg25535999 was associated with PTSD symptom change after correction for multiple comparisons. Responders showed increased methylation at this site.
Recorded limitations
The study examines a complete therapy programme and an association with recovery. It does not establish a causal effect of individual words or show NR3C1 RNA changes.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Longitudinal psychotherapy cohort
- assessment
- Not recorded
- trust Factor
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/36658116/ · https://doi.org/10.1038/s41398-023-02316-6
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- Not recorded
Topics and recorded topic scores
None recordedCitation snapshot and identifiers
- id
- pmid-36658116
- doi
- 10.1038/s41398-023-02316-6
- pmid
- 36658116
- citation Snapshot
- Not recorded
- citations By Collection
- language
- Not recorded
Complete approved library record
- id
- pmid-36658116
- publication Key
- Not recorded
- aliases
- None recorded
- title
- Epigenetics of traumatic stress: The association of NR3C1 methylation and posttraumatic stress disorder symptom changes in response to narrative exposure therapy
- journal
- Translational Psychiatry
- publisher Family
- nature
- publisher Family Label
- Nature Portfolio
- neurotransmitters
- None recorded
- year
- 2023
- authors
- Wilker S, Vukojevic V, Schneider A, Pfeiffer A, Inerle S, Pauly M, Elbert T, Papassotiropoulos A, de Quervain D, Kolassa IT.
- design
- Longitudinal psychotherapy cohort
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1038/s41398-023-02316-6
- pmid
- 36658116
- urls
https://doi.org/10.1038/s41398-023-02316-6 · https://pubmed.ncbi.nlm.nih.gov/36658116/
- collections
language
- categories
Epigenetics
- targets
NR3C1
- priority
- 0
- quotes
- None recorded
- summary
- Change at NR3C1 CpG cg25535999 was associated with PTSD symptom change after correction for multiple comparisons. Responders showed increased methylation at this site.
- limitation
- The study examines a complete therapy programme and an association with recovery. It does not establish a causal effect of individual words or show NR3C1 RNA changes.
- citation Count
- Not recorded
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/36658116/ · https://doi.org/10.1038/s41398-023-02316-6
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- language
- Not recorded
- topics
- None recorded
- journal Key
- translationalpsychiatry
- journal Label
- Translational Psychiatry
- chapter Entries
- None recorded
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- id
- ptsd
- evidence
- field
- title
- text
- Epigenetics of traumatic stress: The association of NR3C1 methylation and posttraumatic stress disorder symptom changes in response to narrative exposure therapy
- matched Text
- posttraumatic stress
- id
- trauma
- evidence
- field
- title
- text
- Epigenetics of traumatic stress: The association of NR3C1 methylation and posttraumatic stress disorder symptom changes in response to narrative exposure therapy
- matched Text
- traumatic
- id
- stress
- evidence
- field
- title
- text
- Epigenetics of traumatic stress: The association of NR3C1 methylation and posttraumatic stress disorder symptom changes in response to narrative exposure therapy
- matched Text
- stress
- conditions
ptsd · trauma · stress
- topic Trust Scores
- None recorded
- full Text
- status
- open-license
- retrieval Available
- true
- url
- https://www.ebi.ac.uk/europepmc/webservices/rest/PMC9852425/fullTextXML
- pmcid
- PMC9852425
- rights
- license
- https://creativecommons.org/licenses/by/4.0/
- statement
© The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/ Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ .
- sha256
- 52fdf2f97f29e4006d676f65454d9ac1d788992559b96c9dcc060e0014e83cb2
- checked At
- 2026-10-24