Photobiomodulation at 660 nm promotes collagen synthesis via downregulation of HIF-1α expression without photodamage in human scleral fibroblasts in vitro in a hypoxic environment
Zhang P, Zhang X, Zhu H. · Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023 · Human scleral fibroblast experiment in vitro
Original publication · Original publication
Recorded summary
In hypoxic human scleral fibroblasts, 660 nm photobiomodulation increased collagen and reduced HIF-1α protein. HIF-1α overexpression attenuated the response.
Recorded limitations
The reported assays concern protein and cellular responses, not clinical myopia outcomes or direct COL1A1 RNA quantification.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Human scleral fibroblast experiment in vitro
- assessment
- Not recorded
- trust Factor
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-applicable
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/37074407/ · https://doi.org/10.1007/s00417-023-06066-5
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- Not recorded
Topics and recorded topic scores
None recordedCitation snapshot and identifiers
- id
- pmid-37074407
- doi
- 10.1007/s00417-023-06066-5
- pmid
- 37074407
- citation Snapshot
- Not recorded
- citations By Collection
- vision
- Not recorded
Complete approved library record
- id
- pmid-37074407
- publication Key
- Not recorded
- aliases
- None recorded
- title
- Photobiomodulation at 660 nm promotes collagen synthesis via downregulation of HIF-1α expression without photodamage in human scleral fibroblasts in vitro in a hypoxic environment
- journal
- Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
- neurotransmitters
- None recorded
- year
- 2023
- authors
- Zhang P, Zhang X, Zhu H.
- design
- Human scleral fibroblast experiment in vitro
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1007/s00417-023-06066-5
- pmid
- 37074407
- urls
https://doi.org/10.1007/s00417-023-06066-5 · https://pubmed.ncbi.nlm.nih.gov/37074407/
- collections
vision
- categories
Molecular biomarkers
- targets
COL1A1
- priority
- 1
- quotes
- None recorded
- summary
- In hypoxic human scleral fibroblasts, 660 nm photobiomodulation increased collagen and reduced HIF-1α protein. HIF-1α overexpression attenuated the response.
- limitation
- The reported assays concern protein and cellular responses, not clinical myopia outcomes or direct COL1A1 RNA quantification.
- citation Count
- Not recorded
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-applicable
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/37074407/ · https://doi.org/10.1007/s00417-023-06066-5
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- vision
- Not recorded
- topics
- None recorded
- journal Key
- graefesarchiveforclinicalandexperimentalophthalmology
- journal Label
- Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
- chapter Entries
- None recorded
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
- None recorded
- full Text
- status
- not-indexed
- retrieval Available
- false