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Neural circuitry for maternal oxytocin release induced by infant cries

Silvana Valtcheva; Habon A. Issa; Chloe J. Bair-Marshall; Kathleen A. Martin; Kanghoon Jung; Yiyao Zhang; Hyung-Bae Kwon; Robert C. Froemke · Nature · 2023 · Experimental mouse neural-circuit study

Original publication · Original publication · Original publication · Original publication

Recorded summary

Pup calls activated a thalamus-to-hypothalamus pathway that promoted maternal oxytocin release in mice. Prolonged disinhibition of oxytocin neurons linked an auditory social cue to neuropeptide release.

Recorded limitations

The study examines maternal responses to infant calls in mice. It does not test music, brain entrainment or human stress reduction.

Evidence and provenance

Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.

Study design and assessment
design
Experimental mouse neural-circuit study
assessment
category
peer-reviewed
peer Reviewed
true
basis
Experimental mouse neural-circuit study. No masked human randomized trial classification is assigned.
sources

https://www.nature.com/articles/s41586-023-06540-4 · https://doi.org/10.1038/s41586-023-06540-4 · https://pmc.ncbi.nlm.nih.gov/articles/PMC10639004/ · https://pubmed.ncbi.nlm.nih.gov/37730989/

reviewed At
2026-10-23
trust Factor
score
1
scope
Paper
status
assessed
randomized Controlled Trial
false
blinding
not-applicable
peer Reviewed
true
basis
Experimental mouse neural-circuit study. No masked human randomized trial classification is assigned.
sources

https://pubmed.ncbi.nlm.nih.gov/37730989/ · https://www.nature.com/articles/s41586-023-06540-4 · https://doi.org/10.1038/s41586-023-06540-4 · https://pmc.ncbi.nlm.nih.gov/articles/PMC10639004/

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
jadad
status
unassessed
score
Not recorded
evidence
evidence Type
Brain & nervous system
sample
Maternal mice
measurement
Neural recordings, circuit manipulation and oxytocin release
measured Genes
None recorded
relationship Note
The study examines maternal responses to infant calls in mice. It does not test music, brain entrainment or human stress reduction.
source URLs

https://www.nature.com/articles/s41586-023-06540-4 · https://doi.org/10.1038/s41586-023-06540-4 · https://pmc.ncbi.nlm.nih.gov/articles/PMC10639004/ · https://pubmed.ncbi.nlm.nih.gov/37730989/

checked At
2026-10-23
Topics and recorded topic scores
  1. key
    general:oxytocin-sensory
    title
    Oxytocin receptors and sensory experience
    collection
    general
    trust Score
    1
Citation snapshot and identifiers
id
pmid-37730989
doi
10.1038/s41586-023-06540-4
pmid
37730989
citation Snapshot
count
110
source
Crossref
retrieved At
2026-10-23
url
https://api.crossref.org/works/10.1038/s41586-023-06540-4
citations By Collection
general
110
Complete approved library record
id
pmid-37730989
aliases
None recorded
title
Neural circuitry for maternal oxytocin release induced by infant cries
journal
Nature
publisher Family
nature
publisher Family Label
Nature Portfolio
neurotransmitters

Oxytocin

year
2023
authors
Silvana Valtcheva; Habon A. Issa; Chloe J. Bair-Marshall; Kathleen A. Martin; Kanghoon Jung; Yiyao Zhang; Hyung-Bae Kwon; Robert C. Froemke
design
Experimental mouse neural-circuit study
kind
Journal article
identity Conflict
Not recorded
doi
10.1038/s41586-023-06540-4
pmid
37730989
urls

https://www.nature.com/articles/s41586-023-06540-4 · https://doi.org/10.1038/s41586-023-06540-4 · https://pmc.ncbi.nlm.nih.gov/articles/PMC10639004/ · https://pubmed.ncbi.nlm.nih.gov/37730989/

collections

general

categories

Brain & nervous system

targets

OXT

priority
1
quotes
None recorded
summary
Pup calls activated a thalamus-to-hypothalamus pathway that promoted maternal oxytocin release in mice. Prolonged disinhibition of oxytocin neurons linked an auditory social cue to neuropeptide release.
limitation
The study examines maternal responses to infant calls in mice. It does not test music, brain entrainment or human stress reduction.
citation Count
110
citation Snapshot
count
110
source
Crossref
retrieved At
2026-10-23
url
https://api.crossref.org/works/10.1038/s41586-023-06540-4
study Design Assessment
category
peer-reviewed
peer Reviewed
true
basis
Experimental mouse neural-circuit study. No masked human randomized trial classification is assigned.
sources

https://www.nature.com/articles/s41586-023-06540-4 · https://doi.org/10.1038/s41586-023-06540-4 · https://pmc.ncbi.nlm.nih.gov/articles/PMC10639004/ · https://pubmed.ncbi.nlm.nih.gov/37730989/

reviewed At
2026-10-23
paper Trust Assessment
score
1
scope
Paper
status
assessed
randomized Controlled Trial
false
blinding
not-applicable
peer Reviewed
true
basis
Experimental mouse neural-circuit study. No masked human randomized trial classification is assigned.
sources

https://pubmed.ncbi.nlm.nih.gov/37730989/ · https://www.nature.com/articles/s41586-023-06540-4 · https://doi.org/10.1038/s41586-023-06540-4 · https://pmc.ncbi.nlm.nih.gov/articles/PMC10639004/

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
citations By Collection
general
110
topics
  1. key
    general:oxytocin-sensory
    title
    Oxytocin receptors and sensory experience
    collection
    general
    trust Score
    1
journal Key
nature
journal Label
Nature
chapter Entries
  1. title
    Neural circuitry for maternal oxytocin release induced by infant cries
    journal
    Nature
    year
    2023
    authors
    Silvana Valtcheva; Habon A. Issa; Chloe J. Bair-Marshall; Kathleen A. Martin; Kanghoon Jung; Yiyao Zhang; Hyung-Bae Kwon; Robert C. Froemke
    design
    Experimental mouse neural-circuit study
    urls

    https://www.nature.com/articles/s41586-023-06540-4 · https://doi.org/10.1038/s41586-023-06540-4 · https://pmc.ncbi.nlm.nih.gov/articles/PMC10639004/ · https://pubmed.ncbi.nlm.nih.gov/37730989/

    doi
    10.1038/s41586-023-06540-4
    pmid
    37730989
    targets

    OXT

    neurotransmitters

    Oxytocin

    categories

    Brain & nervous system

    citation Count
    110
    citation Snapshot
    count
    110
    source
    Crossref
    retrieved At
    2026-10-23
    url
    https://api.crossref.org/works/10.1038/s41586-023-06540-4
    study Design Assessment
    category
    peer-reviewed
    peer Reviewed
    true
    basis
    Experimental mouse neural-circuit study. No masked human randomized trial classification is assigned.
    sources

    https://www.nature.com/articles/s41586-023-06540-4 · https://doi.org/10.1038/s41586-023-06540-4 · https://pmc.ncbi.nlm.nih.gov/articles/PMC10639004/ · https://pubmed.ncbi.nlm.nih.gov/37730989/

    reviewed At
    2026-10-23
    evidence
    evidence Type
    Brain & nervous system
    sample
    Maternal mice
    measurement
    Neural recordings, circuit manipulation and oxytocin release
    measured Genes
    None recorded
    relationship Note
    The study examines maternal responses to infant calls in mice. It does not test music, brain entrainment or human stress reduction.
    source URLs

    https://www.nature.com/articles/s41586-023-06540-4 · https://doi.org/10.1038/s41586-023-06540-4 · https://pmc.ncbi.nlm.nih.gov/articles/PMC10639004/ · https://pubmed.ncbi.nlm.nih.gov/37730989/

    checked At
    2026-10-23
    id
    general-oxytocin-sensory-pmid-37730989
    record Id
    pmid-37730989
    quotes
    None recorded
    source Pages
    None recorded
    summary
    Pup calls activated a thalamus-to-hypothalamus pathway that promoted maternal oxytocin release in mice. Prolonged disinhibition of oxytocin neurons linked an auditory social cue to neuropeptide release.
    limitation
    The study examines maternal responses to infant calls in mice. It does not test music, brain entrainment or human stress reduction.
    paper Trust Assessment
    score
    1
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    false
    blinding
    not-applicable
    peer Reviewed
    true
    basis
    Experimental mouse neural-circuit study. No masked human randomized trial classification is assigned.
    sources

    https://pubmed.ncbi.nlm.nih.gov/37730989/ · https://www.nature.com/articles/s41586-023-06540-4 · https://doi.org/10.1038/s41586-023-06540-4 · https://pmc.ncbi.nlm.nih.gov/articles/PMC10639004/

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    collection
    general
    chapter Number
    8
    topic Id
    oxytocin-sensory
    topic Title
    Oxytocin receptors and sensory experience
    trust Score
    1
evidence
evidence Type
Brain & nervous system
sample
Maternal mice
measurement
Neural recordings, circuit manipulation and oxytocin release
measured Genes
None recorded
relationship Note
The study examines maternal responses to infant calls in mice. It does not test music, brain entrainment or human stress reduction.
source URLs

https://www.nature.com/articles/s41586-023-06540-4 · https://doi.org/10.1038/s41586-023-06540-4 · https://pmc.ncbi.nlm.nih.gov/articles/PMC10639004/ · https://pubmed.ncbi.nlm.nih.gov/37730989/

checked At
2026-10-23
jadad
status
unassessed
score
Not recorded
condition Evidence
None recorded
conditions
None recorded
topic Trust Scores

1

full Text
status
reuse-review
retrieval Available
false
url
https://pmc-oa-opendata.s3.amazonaws.com/PMC10639004.1/PMC10639004.1.xml?md5=1b1542b6f8bfbf6325008bdb63aec4df
pmcid
PMC10639004
rights
license
TDM
use
Private text mining
public Fulltext Redistribution
false
provider Upload
false
model Training
false
basis
https://pmc.ncbi.nlm.nih.gov/tools/pmcaws/
article Rights

This file is available for text mining. It may also be used consistent with the principles of fair use under the copyright law.

sha256
4a95fa348c4bbe8318825d1d78e1bda2ab1cfa277472210598f3da7f1be8a5f9
checked At
2026-10-24

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