Functional involvement of septal miR-132 in extinction and oxytocin-mediated reversal of social fear
Anna Bludau; Uwe Schwartz; Daniela M. Zeitler; Melanie Royer; Gunter Meister; Inga D. Neumann; Rohit Menon · Molecular Psychiatry · 2023 · Experimental mouse molecular study
Original publication · Original publication · Original publication · Original publication
Recorded summary
Septal miR-132 contributed to social-fear extinction and oxytocin-mediated reversal of social fear in male mice. Manipulation in oxytocin-receptor-expressing neurons linked this microRNA to behavioural responses and downstream Gdf5 regulation.
Recorded limitations
The molecular and behavioural findings come from male mice; they do not establish a therapy or biomarker for human social anxiety.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Experimental mouse molecular study
- assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Experimental mouse molecular study. No masked human randomized trial classification is assigned.
- sources
https://www.nature.com/articles/s41380-023-02309-3 · https://doi.org/10.1038/s41380-023-02309-3 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11371636/ · https://pubmed.ncbi.nlm.nih.gov/37938765/
- reviewed At
- 2026-10-23
- trust Factor
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-applicable
- peer Reviewed
- true
- basis
- Experimental mouse molecular study. No masked human randomized trial classification is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/37938765/ · https://www.nature.com/articles/s41380-023-02309-3 · https://doi.org/10.1038/s41380-023-02309-3 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11371636/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- evidence Type
- Gene expression
- sample
- Male mice
- measurement
- Septal microRNA expression and manipulation; social-fear behaviour
- measured Genes
MIR132 · GDF5
- relationship Note
- The molecular and behavioural findings come from male mice; they do not establish a therapy or biomarker for human social anxiety.
- source URLs
https://www.nature.com/articles/s41380-023-02309-3 · https://doi.org/10.1038/s41380-023-02309-3 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11371636/ · https://pubmed.ncbi.nlm.nih.gov/37938765/
- checked At
- 2026-10-23
Topics and recorded topic scores
- key
- general:neurotransmitter-signalling
- title
- Oxytocin, serotonin and dopamine signalling
- collection
- general
- trust Score
- 1
Citation snapshot and identifiers
- id
- pmid-37938765
- doi
- 10.1038/s41380-023-02309-3
- pmid
- 37938765
- citation Snapshot
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- 14
- source
- Crossref
- retrieved At
- 2026-10-23
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- https://api.crossref.org/works/10.1038/s41380-023-02309-3
- citations By Collection
- general
- 14
Complete approved library record
- id
- pmid-37938765
- aliases
- None recorded
- title
- Functional involvement of septal miR-132 in extinction and oxytocin-mediated reversal of social fear
- journal
- Molecular Psychiatry
- publisher Family
- nature
- publisher Family Label
- Nature Portfolio
- neurotransmitters
Oxytocin
- year
- 2023
- authors
- Anna Bludau; Uwe Schwartz; Daniela M. Zeitler; Melanie Royer; Gunter Meister; Inga D. Neumann; Rohit Menon
- design
- Experimental mouse molecular study
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1038/s41380-023-02309-3
- pmid
- 37938765
- urls
https://www.nature.com/articles/s41380-023-02309-3 · https://doi.org/10.1038/s41380-023-02309-3 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11371636/ · https://pubmed.ncbi.nlm.nih.gov/37938765/
- collections
general
- categories
Gene expression
- targets
OXTR · MIR132 · GDF5
- priority
- 0
- quotes
- None recorded
- summary
- Septal miR-132 contributed to social-fear extinction and oxytocin-mediated reversal of social fear in male mice. Manipulation in oxytocin-receptor-expressing neurons linked this microRNA to behavioural responses and downstream Gdf5 regulation.
- limitation
- The molecular and behavioural findings come from male mice; they do not establish a therapy or biomarker for human social anxiety.
- citation Count
- 14
- citation Snapshot
- count
- 14
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1038/s41380-023-02309-3
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Experimental mouse molecular study. No masked human randomized trial classification is assigned.
- sources
https://www.nature.com/articles/s41380-023-02309-3 · https://doi.org/10.1038/s41380-023-02309-3 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11371636/ · https://pubmed.ncbi.nlm.nih.gov/37938765/
- reviewed At
- 2026-10-23
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-applicable
- peer Reviewed
- true
- basis
- Experimental mouse molecular study. No masked human randomized trial classification is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/37938765/ · https://www.nature.com/articles/s41380-023-02309-3 · https://doi.org/10.1038/s41380-023-02309-3 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11371636/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- general
- 14
- topics
- key
- general:neurotransmitter-signalling
- title
- Oxytocin, serotonin and dopamine signalling
- collection
- general
- trust Score
- 1
- journal Key
- molecularpsychiatry
- journal Label
- Molecular Psychiatry
- chapter Entries
- title
- Functional involvement of septal miR-132 in extinction and oxytocin-mediated reversal of social fear
- journal
- Molecular Psychiatry
- year
- 2023
- authors
- Anna Bludau; Uwe Schwartz; Daniela M. Zeitler; Melanie Royer; Gunter Meister; Inga D. Neumann; Rohit Menon
- design
- Experimental mouse molecular study
- urls
https://www.nature.com/articles/s41380-023-02309-3 · https://doi.org/10.1038/s41380-023-02309-3 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11371636/ · https://pubmed.ncbi.nlm.nih.gov/37938765/
- doi
- 10.1038/s41380-023-02309-3
- pmid
- 37938765
- targets
OXTR · MIR132 · GDF5
- neurotransmitters
Oxytocin
- categories
Gene expression
- citation Count
- 14
- citation Snapshot
- count
- 14
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1038/s41380-023-02309-3
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Experimental mouse molecular study. No masked human randomized trial classification is assigned.
- sources
https://www.nature.com/articles/s41380-023-02309-3 · https://doi.org/10.1038/s41380-023-02309-3 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11371636/ · https://pubmed.ncbi.nlm.nih.gov/37938765/
- reviewed At
- 2026-10-23
- evidence
- evidence Type
- Gene expression
- sample
- Male mice
- measurement
- Septal microRNA expression and manipulation; social-fear behaviour
- measured Genes
MIR132 · GDF5
- relationship Note
- The molecular and behavioural findings come from male mice; they do not establish a therapy or biomarker for human social anxiety.
- source URLs
https://www.nature.com/articles/s41380-023-02309-3 · https://doi.org/10.1038/s41380-023-02309-3 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11371636/ · https://pubmed.ncbi.nlm.nih.gov/37938765/
- checked At
- 2026-10-23
- id
- general-neurotransmitter-signalling-pmid-37938765
- record Id
- pmid-37938765
- quotes
- None recorded
- source Pages
- None recorded
- summary
- Septal miR-132 contributed to social-fear extinction and oxytocin-mediated reversal of social fear in male mice. Manipulation in oxytocin-receptor-expressing neurons linked this microRNA to behavioural responses and downstream Gdf5 regulation.
- limitation
- The molecular and behavioural findings come from male mice; they do not establish a therapy or biomarker for human social anxiety.
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-applicable
- peer Reviewed
- true
- basis
- Experimental mouse molecular study. No masked human randomized trial classification is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/37938765/ · https://www.nature.com/articles/s41380-023-02309-3 · https://doi.org/10.1038/s41380-023-02309-3 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11371636/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- collection
- general
- chapter Number
- 8
- topic Id
- neurotransmitter-signalling
- topic Title
- Oxytocin, serotonin and dopamine signalling
- trust Score
- 1
- evidence
- evidence Type
- Gene expression
- sample
- Male mice
- measurement
- Septal microRNA expression and manipulation; social-fear behaviour
- measured Genes
MIR132 · GDF5
- relationship Note
- The molecular and behavioural findings come from male mice; they do not establish a therapy or biomarker for human social anxiety.
- source URLs
https://www.nature.com/articles/s41380-023-02309-3 · https://doi.org/10.1038/s41380-023-02309-3 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11371636/ · https://pubmed.ncbi.nlm.nih.gov/37938765/
- checked At
- 2026-10-23
- jadad
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- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
1
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- https://pmc-oa-opendata.s3.amazonaws.com/PMC11371636.1/PMC11371636.1.xml?md5=9d318f7e60b1a78c08593af6d96074de
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- article Rights
© The Author(s) 2023 2023 https://creativecommons.org/licenses/by/4.0/ Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ .
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- checked At
- 2026-10-24