Mindfulness-Based Stress Reduction Reduces Proinflammatory Gene Regulation But Not Systemic Inflammation Among Older Adults: A Randomized Controlled Trial
Lindsay EK, Marsland AL, Cole SW, Dutcher JM, Greco CM, Wright AGC, Brown KW, Creswell JD. · Psychosomatic medicine · 2024 · Randomized controlled trial; single-blind (laboratory assessors)
Original publication · Original publication · Original publication
Recorded summary
MBSR reduced inferred NF-κB activity relative to the active comparison programme (d=0.17; p=0.028). It did not reduce circulating IL-6 or C-reactive protein. CREB, IRF and glucocorticoid-receptor pathway differences were not statistically significant.
Recorded limitations
The gene-regulation signal was small and did not translate into a measured reduction in systemic inflammation. Pathway activity was inferred from RNA profiles.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Randomized controlled trial; single-blind (laboratory assessors)
- assessment
- basis
- Laboratory technicians were blind to treatment condition; the linked trial register identifies single masking of outcome assessors.
- sources
https://pmc.ncbi.nlm.nih.gov/articles/PMC11098967/ · https://pubmed.ncbi.nlm.nih.gov/37982547/ · https://doi.org/10.1097/psy.0000000000001264 · https://clinicaltrials.gov/study/NCT02888600
- assessed At
- 2026-10-23
- registered Masking Basis
- false
- category
- single-blind-rct
- peer Reviewed
- true
- trust Factor
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- single
- peer Reviewed
- true
- basis
- Laboratory technicians were blind to treatment condition; the linked trial register identifies single masking of outcome assessors.
- sources
https://pubmed.ncbi.nlm.nih.gov/37982547/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC11098967/ · https://doi.org/10.1097/psy.0000000000001264 · https://clinicaltrials.gov/study/NCT02888600
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- intervention
- Mindfulness-based stress reduction (MBSR)
- comparator
- Health Enhancement Program
- sample
- 190 lonely adults aged 65–85
- measurement
- Peripheral blood mononuclear cells; RNA profiling and promoter analysis
- timing
- 8 weeks; follow-up at 3 months
- trial Id
- NCT02888600
- measured Genes
- None recorded
- pathways
NF-κB · CREB · IRF · Glucocorticoid receptor signalling
- evidence Type
- RNA expression
- source URLs
https://pmc.ncbi.nlm.nih.gov/articles/PMC11098967/ · https://pubmed.ncbi.nlm.nih.gov/37982547/ · https://doi.org/10.1097/psy.0000000000001264
- checked At
- 2026-10-23
- review Scope
- Publication abstract and selected full-text methods; Jadad assessment pending
Topics and recorded topic scores
- key
- language:mindfulness-rna
- title
- Mindfulness interventions and gene expression
- collection
- language
- trust Score
- 2
Citation snapshot and identifiers
- id
- pmid-37982547
- doi
- 10.1097/psy.0000000000001264
- pmid
- 37982547
- citation Snapshot
- count
- 15
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1097/psy.0000000000001264
- citations By Collection
- language
- 15
Complete approved library record
- id
- pmid-37982547
- publication Key
- Not recorded
- aliases
- None recorded
- title
- Mindfulness-Based Stress Reduction Reduces Proinflammatory Gene Regulation But Not Systemic Inflammation Among Older Adults: A Randomized Controlled Trial
- journal
- Psychosomatic medicine
- neurotransmitters
- None recorded
- year
- 2024
- authors
- Lindsay EK, Marsland AL, Cole SW, Dutcher JM, Greco CM, Wright AGC, Brown KW, Creswell JD.
- design
- Randomized controlled trial; single-blind (laboratory assessors)
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1097/psy.0000000000001264
- pmid
- 37982547
- urls
https://pmc.ncbi.nlm.nih.gov/articles/PMC11098967/ · https://pubmed.ncbi.nlm.nih.gov/37982547/ · https://doi.org/10.1097/psy.0000000000001264
- collections
language
- categories
Gene expression
- targets
- None recorded
- priority
- 0
- quotes
- None recorded
- summary
- MBSR reduced inferred NF-κB activity relative to the active comparison programme (d=0.17; p=0.028). It did not reduce circulating IL-6 or C-reactive protein. CREB, IRF and glucocorticoid-receptor pathway differences were not statistically significant.
- limitation
- The gene-regulation signal was small and did not translate into a measured reduction in systemic inflammation. Pathway activity was inferred from RNA profiles.
- citation Count
- 15
- citation Snapshot
- count
- 15
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1097/psy.0000000000001264
- study Design Assessment
- basis
- Laboratory technicians were blind to treatment condition; the linked trial register identifies single masking of outcome assessors.
- sources
https://pmc.ncbi.nlm.nih.gov/articles/PMC11098967/ · https://pubmed.ncbi.nlm.nih.gov/37982547/ · https://doi.org/10.1097/psy.0000000000001264 · https://clinicaltrials.gov/study/NCT02888600
- assessed At
- 2026-10-23
- registered Masking Basis
- false
- category
- single-blind-rct
- peer Reviewed
- true
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- single
- peer Reviewed
- true
- basis
- Laboratory technicians were blind to treatment condition; the linked trial register identifies single masking of outcome assessors.
- sources
https://pubmed.ncbi.nlm.nih.gov/37982547/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC11098967/ · https://doi.org/10.1097/psy.0000000000001264 · https://clinicaltrials.gov/study/NCT02888600
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- language
- 15
- topics
- key
- language:mindfulness-rna
- title
- Mindfulness interventions and gene expression
- collection
- language
- trust Score
- 2
- journal Key
- psychosomaticmedicine
- journal Label
- Psychosomatic medicine
- chapter Entries
- id
- language-mindfulness-rna-pmid-37982547
- record Id
- pmid-37982547
- title
- Mindfulness-Based Stress Reduction Reduces Proinflammatory Gene Regulation But Not Systemic Inflammation Among Older Adults: A Randomized Controlled Trial
- journal
- Psychosomatic medicine
- year
- 2024
- authors
- Lindsay EK, Marsland AL, Cole SW, Dutcher JM, Greco CM, Wright AGC, Brown KW, Creswell JD.
- design
- Randomized controlled trial; single-blind (laboratory assessors)
- urls
https://pmc.ncbi.nlm.nih.gov/articles/PMC11098967/ · https://pubmed.ncbi.nlm.nih.gov/37982547/ · https://doi.org/10.1097/psy.0000000000001264
- quotes
- None recorded
- summary
- MBSR reduced inferred NF-κB activity relative to the active comparison programme (d=0.17; p=0.028). It did not reduce circulating IL-6 or C-reactive protein. CREB, IRF and glucocorticoid-receptor pathway differences were not statistically significant.
- limitation
- The gene-regulation signal was small and did not translate into a measured reduction in systemic inflammation. Pathway activity was inferred from RNA profiles.
- citation Count
- 15
- citation Snapshot
- count
- 15
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1097/psy.0000000000001264
- study Design Assessment
- basis
- Laboratory technicians were blind to treatment condition; the linked trial register identifies single masking of outcome assessors.
- sources
https://pmc.ncbi.nlm.nih.gov/articles/PMC11098967/ · https://pubmed.ncbi.nlm.nih.gov/37982547/ · https://doi.org/10.1097/psy.0000000000001264 · https://clinicaltrials.gov/study/NCT02888600
- assessed At
- 2026-10-23
- registered Masking Basis
- false
- category
- single-blind-rct
- peer Reviewed
- true
- source Pages
- None recorded
- targets
- None recorded
- categories
Gene expression
- doi
- 10.1097/psy.0000000000001264
- pmid
- 37982547
- evidence
- intervention
- Mindfulness-based stress reduction (MBSR)
- comparator
- Health Enhancement Program
- sample
- 190 lonely adults aged 65–85
- measurement
- Peripheral blood mononuclear cells; RNA profiling and promoter analysis
- timing
- 8 weeks; follow-up at 3 months
- trial Id
- NCT02888600
- measured Genes
- None recorded
- pathways
NF-κB · CREB · IRF · Glucocorticoid receptor signalling
- evidence Type
- RNA expression
- source URLs
https://pmc.ncbi.nlm.nih.gov/articles/PMC11098967/ · https://pubmed.ncbi.nlm.nih.gov/37982547/ · https://doi.org/10.1097/psy.0000000000001264
- checked At
- 2026-10-23
- review Scope
- Publication abstract and selected full-text methods; Jadad assessment pending
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- single
- peer Reviewed
- true
- basis
- Laboratory technicians were blind to treatment condition; the linked trial register identifies single masking of outcome assessors.
- sources
https://pubmed.ncbi.nlm.nih.gov/37982547/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC11098967/ · https://doi.org/10.1097/psy.0000000000001264 · https://clinicaltrials.gov/study/NCT02888600
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- collection
- language
- chapter Number
- 4
- topic Id
- mindfulness-rna
- topic Title
- Mindfulness interventions and gene expression
- trust Score
- 2
- evidence
- intervention
- Mindfulness-based stress reduction (MBSR)
- comparator
- Health Enhancement Program
- sample
- 190 lonely adults aged 65–85
- measurement
- Peripheral blood mononuclear cells; RNA profiling and promoter analysis
- timing
- 8 weeks; follow-up at 3 months
- trial Id
- NCT02888600
- measured Genes
- None recorded
- pathways
NF-κB · CREB · IRF · Glucocorticoid receptor signalling
- evidence Type
- RNA expression
- source URLs
https://pmc.ncbi.nlm.nih.gov/articles/PMC11098967/ · https://pubmed.ncbi.nlm.nih.gov/37982547/ · https://doi.org/10.1097/psy.0000000000001264
- checked At
- 2026-10-23
- review Scope
- Publication abstract and selected full-text methods; Jadad assessment pending
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
2
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- status
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- https://pmc-oa-opendata.s3.amazonaws.com/PMC11098967.319/PMC11098967.319.xml?md5=d05190b9d4f53781df4336c3187168aa
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This file is available for text mining. It may also be used consistent with the principles of fair use under the copyright law.
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- 1b16dfe2ba8b376ff85637909baac237c51fb570fb20ab9e3948ea59b5be2de8
- checked At
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