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DNA methylation changes in association with trauma-focused psychotherapy efficacy in treatment-resistant depression patients: a prospective longitudinal study.

Carvalho Silva R, Martini P, Hohoff C, Mattevi S, Bortolomasi M, Menesello V, Gennarelli M, Baune BT, Minelli A. · European journal of psychotraumatology · 2024 · Exploratory DNA-methylation study

Original publication · Original publication · Original publication

Recorded summary

Blood DNA methylation was studied in 30 people with treatment-resistant depression receiving EMDR (18) or trauma-focused CBT (12). Differentially methylated regions included inflammation-related genes and pathways.

Recorded limitations

Small treatment groups and concurrent usual care limit attribution. DNA methylation is a separate measurement from RNA expression.

Evidence and provenance

Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.

Study design and assessment
design
Exploratory DNA-methylation study
assessment
category
observational
peer Reviewed
true
basis
Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.
sources

https://pubmed.ncbi.nlm.nih.gov/38362742/ · https://doi.org/10.1080/20008066.2024.2314913

reviewed At
2026-10-23
trust Factor
score
1
scope
Paper
status
assessed
randomized Controlled Trial
Not recorded
blinding
not-confirmed
peer Reviewed
true
basis
Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.
sources

https://pubmed.ncbi.nlm.nih.gov/38362742/ · https://doi.org/10.1080/20008066.2024.2314913

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
jadad
status
unassessed
score
Not recorded
evidence
evidence Type
Epigenetics
measured Genes

LTA · GFI1 · S100A8 · TNF

relationship Note
Small treatment groups and concurrent usual care limit attribution. DNA methylation is a separate measurement from RNA expression.
Topics and recorded topic scores
  1. key
    vision:epigenetics
    title
    EMDR and trauma-focused psychotherapy: DNA methylation
    collection
    vision
    trust Score
    1
Citation snapshot and identifiers
id
pmid-38362742
doi
10.1080/20008066.2024.2314913
pmid
38362742
citation Snapshot
count
26
source
Crossref
retrieved At
2026-10-23
citations By Collection
vision
26
language
Not recorded
Complete approved library record
id
pmid-38362742
publication Key
doi:10.1080/20008066.2024.2314913
aliases
None recorded
title
DNA methylation changes in association with trauma-focused psychotherapy efficacy in treatment-resistant depression patients: a prospective longitudinal study.
journal
European journal of psychotraumatology
neurotransmitters
None recorded
year
2024
authors
Carvalho Silva R, Martini P, Hohoff C, Mattevi S, Bortolomasi M, Menesello V, Gennarelli M, Baune BT, Minelli A.
design
Exploratory DNA-methylation study
kind
Journal article
identity Conflict
Not recorded
doi
10.1080/20008066.2024.2314913
pmid
38362742
urls

https://pmc.ncbi.nlm.nih.gov/articles/PMC10878335/ · https://pubmed.ncbi.nlm.nih.gov/38362742/ · https://doi.org/10.1080/20008066.2024.2314913

collections

vision · language

categories

Epigenetics · Clinical & self-report

targets

LTA · GFI1 · S100A8 · TNF

priority
0
quotes
None recorded
summary
Blood DNA methylation was studied in 30 people with treatment-resistant depression receiving EMDR (18) or trauma-focused CBT (12). Differentially methylated regions included inflammation-related genes and pathways.
limitation
Small treatment groups and concurrent usual care limit attribution. DNA methylation is a separate measurement from RNA expression.
citation Count
26
citation Snapshot
count
26
source
Crossref
retrieved At
2026-10-23
study Design Assessment
category
observational
peer Reviewed
true
basis
Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.
sources

https://pubmed.ncbi.nlm.nih.gov/38362742/ · https://doi.org/10.1080/20008066.2024.2314913

reviewed At
2026-10-23
paper Trust Assessment
score
1
scope
Paper
status
assessed
randomized Controlled Trial
Not recorded
blinding
not-confirmed
peer Reviewed
true
basis
Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.
sources

https://pubmed.ncbi.nlm.nih.gov/38362742/ · https://doi.org/10.1080/20008066.2024.2314913

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
citations By Collection
vision
26
language
Not recorded
topics
  1. key
    vision:epigenetics
    title
    EMDR and trauma-focused psychotherapy: DNA methylation
    collection
    vision
    trust Score
    1
journal Key
europeanjournalofpsychotraumatology
journal Label
European journal of psychotraumatology
chapter Entries
  1. title
    DNA methylation changes in association with trauma-focused psychotherapy efficacy in treatment-resistant depression patients: a prospective longitudinal study.
    journal
    European journal of psychotraumatology
    year
    2024
    authors
    Carvalho Silva R, Martini P, Hohoff C, Mattevi S, Bortolomasi M, Menesello V, Gennarelli M, Baune BT, Minelli A.
    design
    Exploratory DNA-methylation study
    urls

    https://pmc.ncbi.nlm.nih.gov/articles/PMC10878335/ · https://pubmed.ncbi.nlm.nih.gov/38362742/ · https://doi.org/10.1080/20008066.2024.2314913

    doi
    10.1080/20008066.2024.2314913
    pmid
    38362742
    targets

    LTA · GFI1 · S100A8 · TNF

    categories

    Epigenetics · Clinical & self-report

    citation Count
    26
    citation Snapshot
    count
    26
    source
    Crossref
    retrieved At
    2026-10-23
    study Design Assessment
    category
    observational
    peer Reviewed
    true
    basis
    Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.
    sources

    https://pubmed.ncbi.nlm.nih.gov/38362742/ · https://doi.org/10.1080/20008066.2024.2314913

    reviewed At
    2026-10-23
    evidence
    evidence Type
    Epigenetics
    measured Genes

    LTA · GFI1 · S100A8 · TNF

    relationship Note
    Small treatment groups and concurrent usual care limit attribution. DNA methylation is a separate measurement from RNA expression.
    record Id
    pmid-38362742
    quotes
    None recorded
    source Pages
    None recorded
    summary
    Blood DNA methylation was studied in 30 people with treatment-resistant depression receiving EMDR (18) or trauma-focused CBT (12). Differentially methylated regions included inflammation-related genes and pathways.
    limitation
    Small treatment groups and concurrent usual care limit attribution. DNA methylation is a separate measurement from RNA expression.
    id
    vision-epigenetics-pmid-38362742
    paper Trust Assessment
    score
    1
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    Not recorded
    blinding
    not-confirmed
    peer Reviewed
    true
    basis
    Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.
    sources

    https://pubmed.ncbi.nlm.nih.gov/38362742/ · https://doi.org/10.1080/20008066.2024.2314913

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    publication Key
    doi:10.1080/20008066.2024.2314913
    collection
    vision
    chapter Number
    4
    topic Id
    epigenetics
    topic Title
    EMDR and trauma-focused psychotherapy: DNA methylation
    trust Score
    1
evidence
evidence Type
Epigenetics
measured Genes

LTA · GFI1 · S100A8 · TNF

relationship Note
Small treatment groups and concurrent usual care limit attribution. DNA methylation is a separate measurement from RNA expression.
jadad
status
unassessed
score
Not recorded
condition Evidence
  1. id
    trauma
    evidence
    1. field
      title
      text
      DNA methylation changes in association with trauma-focused psychotherapy efficacy in treatment-resistant depression patients: a prospective longitudinal study.
      matched Text
      trauma
  2. id
    depression
    evidence
    1. field
      title
      text
      DNA methylation changes in association with trauma-focused psychotherapy efficacy in treatment-resistant depression patients: a prospective longitudinal study.
      matched Text
      depression
conditions

trauma · depression

topic Trust Scores

1

full Text
status
not-indexed
retrieval Available
false

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