Multisensory gamma stimulation promotes glymphatic clearance of amyloid
Murdock MH, Yang CY, Sun N, Pao PC, Blanco-Duque C, Kahn MC, Kim T, Lavoie NS, Victor MB, Islam MR, Galiana F, Leary N, Wang S, Bubnys A, Ma E, Akay LA, Sneve M, Qian Y, Lai C, McCarthy MM, Kopell N, Kellis M, Piatkevich KD, Boyden ES, Tsai LH. · Nature · 2024 · Mouse Alzheimer-disease model experiments
Original publication · Original publication · Original publication
Recorded summary
Combined 40 Hz sensory stimulation increased brain-fluid clearance and reduced amyloid in the tested mouse model. Mechanistic experiments implicated VIP interneurons and glymphatic function.
Recorded limitations
This is multisensory animal research. It does not isolate visual effects, establish clinical efficacy or test OXTR–Fibonacci relationships.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Mouse Alzheimer-disease model experiments
- assessment
- Not recorded
- trust Factor
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-applicable
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/38418876/ · https://doi.org/10.1038/s41586-024-07132-6
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- Not recorded
Topics and recorded topic scores
None recordedCitation snapshot and identifiers
- id
- pmid-38418876
- doi
- 10.1038/s41586-024-07132-6
- pmid
- 38418876
- citation Snapshot
- Not recorded
- citations By Collection
- vision
- Not recorded
- sound
- Not recorded
Complete approved library record
- id
- pmid-38418876
- publication Key
- Not recorded
- aliases
- None recorded
- title
- Multisensory gamma stimulation promotes glymphatic clearance of amyloid
- journal
- Nature
- publisher Family
- nature
- publisher Family Label
- Nature Portfolio
- neurotransmitters
- None recorded
- year
- 2024
- authors
- Murdock MH, Yang CY, Sun N, Pao PC, Blanco-Duque C, Kahn MC, Kim T, Lavoie NS, Victor MB, Islam MR, Galiana F, Leary N, Wang S, Bubnys A, Ma E, Akay LA, Sneve M, Qian Y, Lai C, McCarthy MM, Kopell N, Kellis M, Piatkevich KD, Boyden ES, Tsai LH.
- design
- Mouse Alzheimer-disease model experiments
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1038/s41586-024-07132-6
- pmid
- 38418876
- urls
https://doi.org/10.1038/s41586-024-07132-6 · https://pmc.ncbi.nlm.nih.gov/articles/PMC10917684/ · https://pubmed.ncbi.nlm.nih.gov/38418876/
- collections
vision · sound
- categories
Brain & nervous system · Molecular biomarkers
- targets
- None recorded
- priority
- 1
- quotes
- None recorded
- summary
- Combined 40 Hz sensory stimulation increased brain-fluid clearance and reduced amyloid in the tested mouse model. Mechanistic experiments implicated VIP interneurons and glymphatic function.
- limitation
- This is multisensory animal research. It does not isolate visual effects, establish clinical efficacy or test OXTR–Fibonacci relationships.
- citation Count
- Not recorded
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-applicable
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/38418876/ · https://doi.org/10.1038/s41586-024-07132-6
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- vision
- Not recorded
- sound
- Not recorded
- topics
- None recorded
- journal Key
- nature
- journal Label
- Nature
- chapter Entries
- None recorded
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
- None recorded
- full Text
- status
- open-license
- retrieval Available
- true
- url
- https://www.ebi.ac.uk/europepmc/webservices/rest/PMC10917684/fullTextXML
- pmcid
- PMC10917684
- rights
- license
- https://creativecommons.org/licenses/by/4.0/
- statement
© The Author(s) 2024 https://creativecommons.org/licenses/by/4.0/ Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ .
- sha256
- eabab369067eb27be4838b6ed7c6d34e294321c752425b0ad0da05c3ce1f8c4b
- checked At
- 2026-10-24