Serotonin Transporter (SLC6A4) and FK506-Binding Protein 5 (FKBP5) Genotype and Methylation Relationships with Response to Meditation in Veterans with PTSD
Lee A, Thuras P, Baller J, Jiao C, Guo B, Erbes CR, Polusny MA, Liu C, Wu B, Lim KO, Bishop JR. · Molecular neurobiology · 2024 · Secondary analysis of two intervention studies
Original publication · Original publication
Recorded summary
SLC6A4 genotype was associated with symptom improvement among veterans exposed to early-life trauma. Change in a group of nine FKBP5 methylation sites was associated with greater improvement (OR 2.8; 95% CI 1.1–7.1).
Recorded limitations
Genotype and DNA methylation were measured; this is not direct RNA-expression evidence. Associations across two meditation studies do not isolate a treatment mechanism.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Secondary analysis of two intervention studies
- assessment
- basis
- The reported analysis relates genotype and methylation to response across two studies; it is not an independent blinded randomized treatment comparison.
- sources
https://pubmed.ncbi.nlm.nih.gov/38671329/ · https://doi.org/10.1007/s12035-024-04096-6
- assessed At
- 2026-10-23
- registered Masking Basis
- false
- category
- peer-reviewed
- peer Reviewed
- true
- trust Factor
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- The reported analysis relates genotype and methylation to response across two studies; it is not an independent blinded randomized treatment comparison.
- sources
https://pubmed.ncbi.nlm.nih.gov/38671329/ · https://doi.org/10.1007/s12035-024-04096-6
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- intervention
- MBSR and Transcendental Meditation
- comparator
- Treatment-response associations
- sample
- 72 veterans with PTSD
- measurement
- DNA genotyping and CpG methylation in SLC6A4 and FKBP5
- timing
- Before and after 9 weeks
- trial Id
- Not recorded
- measured Genes
SLC6A4 · FKBP5
- pathways
- None recorded
- evidence Type
- DNA methylation / genotype
- source URLs
https://pubmed.ncbi.nlm.nih.gov/38671329/ · https://doi.org/10.1007/s12035-024-04096-6
- checked At
- 2026-10-23
- review Scope
- Publication abstract; full methods and parent-trial identities await verification. Jadad assessment pending.
- relationship Note
- Secondary analysis draws on MBSR and TM trial participants; it is not an independent treatment trial.
Topics and recorded topic scores
- key
- language:mindfulness-epigenetics
- title
- Mindfulness, DNA methylation and genetic variation
- collection
- language
- trust Score
- 1
Citation snapshot and identifiers
- id
- pmid-38671329
- doi
- 10.1007/s12035-024-04096-6
- pmid
- 38671329
- citation Snapshot
- count
- 9
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1007/s12035-024-04096-6
- citations By Collection
- language
- 9
Complete approved library record
- id
- pmid-38671329
- publication Key
- Not recorded
- aliases
- None recorded
- title
- Serotonin Transporter (SLC6A4) and FK506-Binding Protein 5 (FKBP5) Genotype and Methylation Relationships with Response to Meditation in Veterans with PTSD
- journal
- Molecular neurobiology
- neurotransmitters
- None recorded
- year
- 2024
- authors
- Lee A, Thuras P, Baller J, Jiao C, Guo B, Erbes CR, Polusny MA, Liu C, Wu B, Lim KO, Bishop JR.
- design
- Secondary analysis of two intervention studies
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1007/s12035-024-04096-6
- pmid
- 38671329
- urls
https://doi.org/10.1007/s12035-024-04096-6 · https://pubmed.ncbi.nlm.nih.gov/38671329/
- collections
language
- categories
Epigenetics
- targets
SLC6A4 · FKBP5
- priority
- 0
- quotes
- None recorded
- summary
- SLC6A4 genotype was associated with symptom improvement among veterans exposed to early-life trauma. Change in a group of nine FKBP5 methylation sites was associated with greater improvement (OR 2.8; 95% CI 1.1–7.1).
- limitation
- Genotype and DNA methylation were measured; this is not direct RNA-expression evidence. Associations across two meditation studies do not isolate a treatment mechanism.
- citation Count
- 9
- citation Snapshot
- count
- 9
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1007/s12035-024-04096-6
- study Design Assessment
- basis
- The reported analysis relates genotype and methylation to response across two studies; it is not an independent blinded randomized treatment comparison.
- sources
https://pubmed.ncbi.nlm.nih.gov/38671329/ · https://doi.org/10.1007/s12035-024-04096-6
- assessed At
- 2026-10-23
- registered Masking Basis
- false
- category
- peer-reviewed
- peer Reviewed
- true
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- The reported analysis relates genotype and methylation to response across two studies; it is not an independent blinded randomized treatment comparison.
- sources
https://pubmed.ncbi.nlm.nih.gov/38671329/ · https://doi.org/10.1007/s12035-024-04096-6
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- language
- 9
- topics
- key
- language:mindfulness-epigenetics
- title
- Mindfulness, DNA methylation and genetic variation
- collection
- language
- trust Score
- 1
- journal Key
- molecularneurobiology
- journal Label
- Molecular neurobiology
- chapter Entries
- id
- language-mindfulness-epigenetics-pmid-38671329
- record Id
- pmid-38671329
- title
- Serotonin Transporter (SLC6A4) and FK506-Binding Protein 5 (FKBP5) Genotype and Methylation Relationships with Response to Meditation in Veterans with PTSD
- journal
- Molecular neurobiology
- year
- 2024
- authors
- Lee A, Thuras P, Baller J, Jiao C, Guo B, Erbes CR, Polusny MA, Liu C, Wu B, Lim KO, Bishop JR.
- design
- Secondary analysis of two intervention studies
- urls
https://doi.org/10.1007/s12035-024-04096-6 · https://pubmed.ncbi.nlm.nih.gov/38671329/
- quotes
- None recorded
- summary
- SLC6A4 genotype was associated with symptom improvement among veterans exposed to early-life trauma. Change in a group of nine FKBP5 methylation sites was associated with greater improvement (OR 2.8; 95% CI 1.1–7.1).
- limitation
- Genotype and DNA methylation were measured; this is not direct RNA-expression evidence. Associations across two meditation studies do not isolate a treatment mechanism.
- citation Count
- 9
- citation Snapshot
- count
- 9
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1007/s12035-024-04096-6
- study Design Assessment
- basis
- The reported analysis relates genotype and methylation to response across two studies; it is not an independent blinded randomized treatment comparison.
- sources
https://pubmed.ncbi.nlm.nih.gov/38671329/ · https://doi.org/10.1007/s12035-024-04096-6
- assessed At
- 2026-10-23
- registered Masking Basis
- false
- category
- peer-reviewed
- peer Reviewed
- true
- source Pages
- None recorded
- targets
SLC6A4 · FKBP5
- categories
Epigenetics
- doi
- 10.1007/s12035-024-04096-6
- pmid
- 38671329
- evidence
- intervention
- MBSR and Transcendental Meditation
- comparator
- Treatment-response associations
- sample
- 72 veterans with PTSD
- measurement
- DNA genotyping and CpG methylation in SLC6A4 and FKBP5
- timing
- Before and after 9 weeks
- trial Id
- Not recorded
- measured Genes
SLC6A4 · FKBP5
- pathways
- None recorded
- evidence Type
- DNA methylation / genotype
- source URLs
https://pubmed.ncbi.nlm.nih.gov/38671329/ · https://doi.org/10.1007/s12035-024-04096-6
- checked At
- 2026-10-23
- review Scope
- Publication abstract; full methods and parent-trial identities await verification. Jadad assessment pending.
- relationship Note
- Secondary analysis draws on MBSR and TM trial participants; it is not an independent treatment trial.
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- The reported analysis relates genotype and methylation to response across two studies; it is not an independent blinded randomized treatment comparison.
- sources
https://pubmed.ncbi.nlm.nih.gov/38671329/ · https://doi.org/10.1007/s12035-024-04096-6
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- collection
- language
- chapter Number
- 4
- topic Id
- mindfulness-epigenetics
- topic Title
- Mindfulness, DNA methylation and genetic variation
- trust Score
- 1
- evidence
- intervention
- MBSR and Transcendental Meditation
- comparator
- Treatment-response associations
- sample
- 72 veterans with PTSD
- measurement
- DNA genotyping and CpG methylation in SLC6A4 and FKBP5
- timing
- Before and after 9 weeks
- trial Id
- Not recorded
- measured Genes
SLC6A4 · FKBP5
- pathways
- None recorded
- evidence Type
- DNA methylation / genotype
- source URLs
https://pubmed.ncbi.nlm.nih.gov/38671329/ · https://doi.org/10.1007/s12035-024-04096-6
- checked At
- 2026-10-23
- review Scope
- Publication abstract; full methods and parent-trial identities await verification. Jadad assessment pending.
- relationship Note
- Secondary analysis draws on MBSR and TM trial participants; it is not an independent treatment trial.
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- id
- ptsd
- evidence
- field
- title
- text
- Serotonin Transporter (SLC6A4) and FK506-Binding Protein 5 (FKBP5) Genotype and Methylation Relationships with Response to Meditation in Veterans with PTSD
- matched Text
- PTSD
- field
- evidence.sample
- text
- 72 veterans with PTSD
- matched Text
- PTSD
- conditions
ptsd
- topic Trust Scores
1
- full Text
- status
- not-indexed
- retrieval Available
- false