CD38 Deficiency Protects Mouse Retinal Ganglion Cells Through Activating the NAD+/Sirt1 Pathway in Ischemia-Reperfusion and Optic Nerve Crush Models
Pang Y, Hu H, Xu K, Cao T, Wang Z, Nie J, Zheng H, Luo H, Wang F, Xiong C, Deng KY, Xin HB, Zhang X. · Investigative ophthalmology & visual science · 2024 · Mouse retinal-injury and gene-deletion experiments
Original publication · Original publication · Original publication
Recorded summary
CD38 deletion reduced retinal injury and inflammatory responses, with evidence implicating the NAD+/Sirt1 pathway.
Recorded limitations
Gene deletion and retinal-injury models do not establish that visual exposure regulates CD38. NAD+ is a metabolite, not a gene.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Mouse retinal-injury and gene-deletion experiments
- assessment
- Not recorded
- trust Factor
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-applicable
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/38776115/ · https://doi.org/10.1167/iovs.65.5.36
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- Not recorded
Topics and recorded topic scores
None recordedCitation snapshot and identifiers
- id
- pmid-38776115
- doi
- 10.1167/iovs.65.5.36
- pmid
- 38776115
- citation Snapshot
- Not recorded
- citations By Collection
- vision
- Not recorded
Complete approved library record
- id
- pmid-38776115
- publication Key
- Not recorded
- aliases
- None recorded
- title
- CD38 Deficiency Protects Mouse Retinal Ganglion Cells Through Activating the NAD+/Sirt1 Pathway in Ischemia-Reperfusion and Optic Nerve Crush Models
- journal
- Investigative ophthalmology & visual science
- neurotransmitters
- None recorded
- year
- 2024
- authors
- Pang Y, Hu H, Xu K, Cao T, Wang Z, Nie J, Zheng H, Luo H, Wang F, Xiong C, Deng KY, Xin HB, Zhang X.
- design
- Mouse retinal-injury and gene-deletion experiments
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1167/iovs.65.5.36
- pmid
- 38776115
- urls
https://pmc.ncbi.nlm.nih.gov/articles/PMC11127494/ · https://pubmed.ncbi.nlm.nih.gov/38776115/ · https://doi.org/10.1167/iovs.65.5.36
- collections
vision
- categories
Genetics & genomics · Molecular biomarkers
- targets
CD38 · NAD+ · TNF
- priority
- 0
- quotes
- None recorded
- summary
- CD38 deletion reduced retinal injury and inflammatory responses, with evidence implicating the NAD+/Sirt1 pathway.
- limitation
- Gene deletion and retinal-injury models do not establish that visual exposure regulates CD38. NAD+ is a metabolite, not a gene.
- citation Count
- Not recorded
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-applicable
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/38776115/ · https://doi.org/10.1167/iovs.65.5.36
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- vision
- Not recorded
- topics
- None recorded
- journal Key
- investigativeophthalmologyandvisualscience
- journal Label
- Investigative ophthalmology & visual science
- chapter Entries
- None recorded
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
- None recorded
- full Text
- status
- not-indexed
- retrieval Available
- false