Self-administered mindfulness interventions reduce stress in a large, randomized controlled multi-site study
Alessandro Sparacio; Hans IJzerman; Ivan Ropovik; Filippo Giorgini; Christoph Spiessens; Bert N. Uchino; Joshua Landvatter; Tracey Tacana; Sandra J. Diller; Jaye L. Derrick; Joahana Segundo; Jace D. Pierce; Robert M. Ross; Zoë Francis; Amanda LaBoucane; Christine Ma-Kellams; Maire B. Ford; Kathleen Schmidt; Celia C. Wong; Wendy C. Higgins; Bryant M. Stone; Samantha K. Stanley; Gianni Ribeiro; Paul T. Fuglestad; Valerie Jaklin; Andrea Kübler; Philipp Ziebell; Crystal L. Jewell; Yulia Kovas; Mahnoosh Allahghadri; Charlotte Fransham; Michael F. Baranski; Hannah Burgess; Annika B. E. Benz; Maysa DeSousa; Catherine E. Nylin; Janae C. Brooks; Caitlyn M. Goldsmith; Jessica M. Benson; Siobhán M. Griffin; Stephen Dunne; William E. Davis; Tam J. Watermeyer; William B. Meese; Jennifer L. Howell; Laurel Standiford Reyes; Megan G. Strickland; Sally S. Dickerson; Samantha Pescatore; Shayna Skakoon-Sparling; Zachary I. Wunder; Martin V. Day; Shawna Brenton; Audrey H. Linden; Christopher E. Hawk; Léan V. O’Brien; Tenzin Urgyen; Jennifer S. McDonald; Kim Lien van der Schans; Heidi Blocker; Caroline Ng Tseung-Wong; Gabriela M. Jiga-Boy · Nature Human Behaviour · 2024 · Randomized controlled multisite study
Original publication · Original publication · Original publication · Original publication
Recorded summary
Across 37 sites and 2,239 participants, four brief self-administered mindfulness exercises reduced immediate self-reported stress compared with an active control. The body-scan exercise produced the largest reduction among the tested exercises.
Recorded limitations
The outcomes were short term and self-reported, with predominantly English-speaking participants in higher-income settings. Gene expression was not measured.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Randomized controlled multisite study
- assessment
- category
- rct
- peer Reviewed
- true
- basis
- Random assignment and an active comparison are reported. A single- or double-blind classification is not established from the reviewed methods.
- sources
https://www.nature.com/articles/s41562-024-01907-7 · https://doi.org/10.1038/s41562-024-01907-7 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11420060/ · https://pubmed.ncbi.nlm.nih.gov/38862815/
- reviewed At
- 2026-10-23
- trust Factor
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Random assignment and an active comparison are reported. A single- or double-blind classification is not established from the reviewed methods.
- sources
https://pubmed.ncbi.nlm.nih.gov/38862815/ · https://www.nature.com/articles/s41562-024-01907-7 · https://doi.org/10.1038/s41562-024-01907-7 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11420060/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- evidence Type
- Clinical & self-report
- sample
- 2,239 participants at 37 sites
- measurement
- Immediate self-reported stress
- measured Genes
- None recorded
- relationship Note
- The outcomes were short term and self-reported, with predominantly English-speaking participants in higher-income settings. Gene expression was not measured.
- source URLs
https://www.nature.com/articles/s41562-024-01907-7 · https://doi.org/10.1038/s41562-024-01907-7 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11420060/ · https://pubmed.ncbi.nlm.nih.gov/38862815/
- checked At
- 2026-10-23
Topics and recorded topic scores
- key
- language:mindfulness-clinical
- title
- Mindfulness-based interventions: controlled clinical trials
- collection
- language
- trust Score
- 2
Citation snapshot and identifiers
- id
- pmid-38862815
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- 10.1038/s41562-024-01907-7
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- 38862815
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- 24
- source
- Crossref
- retrieved At
- 2026-10-23
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- https://api.crossref.org/works/10.1038/s41562-024-01907-7
- citations By Collection
- language
- 24
Complete approved library record
- id
- pmid-38862815
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- title
- Self-administered mindfulness interventions reduce stress in a large, randomized controlled multi-site study
- journal
- Nature Human Behaviour
- publisher Family
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- publisher Family Label
- Nature Portfolio
- neurotransmitters
- None recorded
- year
- 2024
- authors
- Alessandro Sparacio; Hans IJzerman; Ivan Ropovik; Filippo Giorgini; Christoph Spiessens; Bert N. Uchino; Joshua Landvatter; Tracey Tacana; Sandra J. Diller; Jaye L. Derrick; Joahana Segundo; Jace D. Pierce; Robert M. Ross; Zoë Francis; Amanda LaBoucane; Christine Ma-Kellams; Maire B. Ford; Kathleen Schmidt; Celia C. Wong; Wendy C. Higgins; Bryant M. Stone; Samantha K. Stanley; Gianni Ribeiro; Paul T. Fuglestad; Valerie Jaklin; Andrea Kübler; Philipp Ziebell; Crystal L. Jewell; Yulia Kovas; Mahnoosh Allahghadri; Charlotte Fransham; Michael F. Baranski; Hannah Burgess; Annika B. E. Benz; Maysa DeSousa; Catherine E. Nylin; Janae C. Brooks; Caitlyn M. Goldsmith; Jessica M. Benson; Siobhán M. Griffin; Stephen Dunne; William E. Davis; Tam J. Watermeyer; William B. Meese; Jennifer L. Howell; Laurel Standiford Reyes; Megan G. Strickland; Sally S. Dickerson; Samantha Pescatore; Shayna Skakoon-Sparling; Zachary I. Wunder; Martin V. Day; Shawna Brenton; Audrey H. Linden; Christopher E. Hawk; Léan V. O’Brien; Tenzin Urgyen; Jennifer S. McDonald; Kim Lien van der Schans; Heidi Blocker; Caroline Ng Tseung-Wong; Gabriela M. Jiga-Boy
- design
- Randomized controlled multisite study
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1038/s41562-024-01907-7
- pmid
- 38862815
- urls
https://www.nature.com/articles/s41562-024-01907-7 · https://doi.org/10.1038/s41562-024-01907-7 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11420060/ · https://pubmed.ncbi.nlm.nih.gov/38862815/
- collections
language
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Clinical & self-report
- targets
- None recorded
- priority
- 1
- quotes
- None recorded
- summary
- Across 37 sites and 2,239 participants, four brief self-administered mindfulness exercises reduced immediate self-reported stress compared with an active control. The body-scan exercise produced the largest reduction among the tested exercises.
- limitation
- The outcomes were short term and self-reported, with predominantly English-speaking participants in higher-income settings. Gene expression was not measured.
- citation Count
- 24
- citation Snapshot
- count
- 24
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1038/s41562-024-01907-7
- study Design Assessment
- category
- rct
- peer Reviewed
- true
- basis
- Random assignment and an active comparison are reported. A single- or double-blind classification is not established from the reviewed methods.
- sources
https://www.nature.com/articles/s41562-024-01907-7 · https://doi.org/10.1038/s41562-024-01907-7 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11420060/ · https://pubmed.ncbi.nlm.nih.gov/38862815/
- reviewed At
- 2026-10-23
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Random assignment and an active comparison are reported. A single- or double-blind classification is not established from the reviewed methods.
- sources
https://pubmed.ncbi.nlm.nih.gov/38862815/ · https://www.nature.com/articles/s41562-024-01907-7 · https://doi.org/10.1038/s41562-024-01907-7 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11420060/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- language
- 24
- topics
- key
- language:mindfulness-clinical
- title
- Mindfulness-based interventions: controlled clinical trials
- collection
- language
- trust Score
- 2
- journal Key
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- journal Label
- Nature Human Behaviour
- chapter Entries
- title
- Self-administered mindfulness interventions reduce stress in a large, randomized controlled multi-site study
- journal
- Nature Human Behaviour
- year
- 2024
- authors
- Alessandro Sparacio; Hans IJzerman; Ivan Ropovik; Filippo Giorgini; Christoph Spiessens; Bert N. Uchino; Joshua Landvatter; Tracey Tacana; Sandra J. Diller; Jaye L. Derrick; Joahana Segundo; Jace D. Pierce; Robert M. Ross; Zoë Francis; Amanda LaBoucane; Christine Ma-Kellams; Maire B. Ford; Kathleen Schmidt; Celia C. Wong; Wendy C. Higgins; Bryant M. Stone; Samantha K. Stanley; Gianni Ribeiro; Paul T. Fuglestad; Valerie Jaklin; Andrea Kübler; Philipp Ziebell; Crystal L. Jewell; Yulia Kovas; Mahnoosh Allahghadri; Charlotte Fransham; Michael F. Baranski; Hannah Burgess; Annika B. E. Benz; Maysa DeSousa; Catherine E. Nylin; Janae C. Brooks; Caitlyn M. Goldsmith; Jessica M. Benson; Siobhán M. Griffin; Stephen Dunne; William E. Davis; Tam J. Watermeyer; William B. Meese; Jennifer L. Howell; Laurel Standiford Reyes; Megan G. Strickland; Sally S. Dickerson; Samantha Pescatore; Shayna Skakoon-Sparling; Zachary I. Wunder; Martin V. Day; Shawna Brenton; Audrey H. Linden; Christopher E. Hawk; Léan V. O’Brien; Tenzin Urgyen; Jennifer S. McDonald; Kim Lien van der Schans; Heidi Blocker; Caroline Ng Tseung-Wong; Gabriela M. Jiga-Boy
- design
- Randomized controlled multisite study
- urls
https://www.nature.com/articles/s41562-024-01907-7 · https://doi.org/10.1038/s41562-024-01907-7 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11420060/ · https://pubmed.ncbi.nlm.nih.gov/38862815/
- doi
- 10.1038/s41562-024-01907-7
- pmid
- 38862815
- targets
- None recorded
- neurotransmitters
- None recorded
- categories
Clinical & self-report
- citation Count
- 24
- citation Snapshot
- count
- 24
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1038/s41562-024-01907-7
- study Design Assessment
- category
- rct
- peer Reviewed
- true
- basis
- Random assignment and an active comparison are reported. A single- or double-blind classification is not established from the reviewed methods.
- sources
https://www.nature.com/articles/s41562-024-01907-7 · https://doi.org/10.1038/s41562-024-01907-7 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11420060/ · https://pubmed.ncbi.nlm.nih.gov/38862815/
- reviewed At
- 2026-10-23
- evidence
- evidence Type
- Clinical & self-report
- sample
- 2,239 participants at 37 sites
- measurement
- Immediate self-reported stress
- measured Genes
- None recorded
- relationship Note
- The outcomes were short term and self-reported, with predominantly English-speaking participants in higher-income settings. Gene expression was not measured.
- source URLs
https://www.nature.com/articles/s41562-024-01907-7 · https://doi.org/10.1038/s41562-024-01907-7 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11420060/ · https://pubmed.ncbi.nlm.nih.gov/38862815/
- checked At
- 2026-10-23
- id
- language-mindfulness-clinical-pmid-38862815
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- quotes
- None recorded
- source Pages
- None recorded
- summary
- Across 37 sites and 2,239 participants, four brief self-administered mindfulness exercises reduced immediate self-reported stress compared with an active control. The body-scan exercise produced the largest reduction among the tested exercises.
- limitation
- The outcomes were short term and self-reported, with predominantly English-speaking participants in higher-income settings. Gene expression was not measured.
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Random assignment and an active comparison are reported. A single- or double-blind classification is not established from the reviewed methods.
- sources
https://pubmed.ncbi.nlm.nih.gov/38862815/ · https://www.nature.com/articles/s41562-024-01907-7 · https://doi.org/10.1038/s41562-024-01907-7 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11420060/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- collection
- language
- chapter Number
- 4
- topic Id
- mindfulness-clinical
- topic Title
- Mindfulness-based interventions: controlled clinical trials
- trust Score
- 2
- evidence
- evidence Type
- Clinical & self-report
- sample
- 2,239 participants at 37 sites
- measurement
- Immediate self-reported stress
- measured Genes
- None recorded
- relationship Note
- The outcomes were short term and self-reported, with predominantly English-speaking participants in higher-income settings. Gene expression was not measured.
- source URLs
https://www.nature.com/articles/s41562-024-01907-7 · https://doi.org/10.1038/s41562-024-01907-7 · https://pmc.ncbi.nlm.nih.gov/articles/PMC11420060/ · https://pubmed.ncbi.nlm.nih.gov/38862815/
- checked At
- 2026-10-23
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2
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- article Rights
© The Author(s) 2024, corrected publication 2024 2024 https://creativecommons.org/licenses/by/4.0/ Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ .
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