Distinct saliva DNA methylation profiles in relation to treatment outcome in youth with posttraumatic stress disorder.
Ensink JBM, Henneman P, Venema A, Zantvoord JB, den Kelder RO, Mannens MMAM, Lindauer RJL. · Translational Psychiatry · 2024 · Longitudinal DNA-methylation study
Original publication · Original publication · Original publication
Recorded summary
The study included 46 young people with PTSD and 41 trauma-exposed controls, aged 8–18. Saliva DNA-methylation differences associated with treatment response included C18orf63 and the stress-related CRHR2 locus.
Recorded limitations
Treatment combined evidence from EMDR and trauma-focused CBT. Saliva findings do not establish a brain-tissue effect or isolate eye movements.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Longitudinal DNA-methylation study
- assessment
- category
- observational
- peer Reviewed
- true
- basis
- Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/39060246/ · https://doi.org/10.1038/s41398-024-02892-1
- reviewed At
- 2026-10-23
- trust Factor
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/39060246/ · https://doi.org/10.1038/s41398-024-02892-1
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- evidence Type
- Epigenetics
- measured Genes
C18orf63 · CRHR2 · NUP35
- relationship Note
- Treatment combined evidence from EMDR and trauma-focused CBT. Saliva findings do not establish a brain-tissue effect or isolate eye movements.
Topics and recorded topic scores
- key
- vision:epigenetics
- title
- EMDR and trauma-focused psychotherapy: DNA methylation
- collection
- vision
- trust Score
- 1
Citation snapshot and identifiers
- id
- pmid-39060246
- doi
- 10.1038/s41398-024-02892-1
- pmid
- 39060246
- citation Snapshot
- count
- 7
- source
- Crossref
- retrieved At
- 2026-10-23
- citations By Collection
- vision
- 7
- language
- Not recorded
Complete approved library record
- id
- pmid-39060246
- publication Key
- doi:10.1038/s41398-024-02892-1
- aliases
- None recorded
- title
- Distinct saliva DNA methylation profiles in relation to treatment outcome in youth with posttraumatic stress disorder.
- journal
- Translational Psychiatry
- publisher Family
- nature
- publisher Family Label
- Nature Portfolio
- neurotransmitters
- None recorded
- year
- 2024
- authors
- Ensink JBM, Henneman P, Venema A, Zantvoord JB, den Kelder RO, Mannens MMAM, Lindauer RJL.
- design
- Longitudinal DNA-methylation study
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1038/s41398-024-02892-1
- pmid
- 39060246
- urls
https://pmc.ncbi.nlm.nih.gov/articles/PMC11282249/ · https://pubmed.ncbi.nlm.nih.gov/39060246/ · https://doi.org/10.1038/s41398-024-02892-1
- collections
vision · language
- categories
Epigenetics · Clinical & self-report
- targets
C18orf63 · CRHR2 · NUP35
- priority
- 0
- quotes
- None recorded
- summary
- The study included 46 young people with PTSD and 41 trauma-exposed controls, aged 8–18. Saliva DNA-methylation differences associated with treatment response included C18orf63 and the stress-related CRHR2 locus.
- limitation
- Treatment combined evidence from EMDR and trauma-focused CBT. Saliva findings do not establish a brain-tissue effect or isolate eye movements.
- citation Count
- 7
- citation Snapshot
- count
- 7
- source
- Crossref
- retrieved At
- 2026-10-23
- study Design Assessment
- category
- observational
- peer Reviewed
- true
- basis
- Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/39060246/ · https://doi.org/10.1038/s41398-024-02892-1
- reviewed At
- 2026-10-23
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/39060246/ · https://doi.org/10.1038/s41398-024-02892-1
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- vision
- 7
- language
- Not recorded
- topics
- key
- vision:epigenetics
- title
- EMDR and trauma-focused psychotherapy: DNA methylation
- collection
- vision
- trust Score
- 1
- journal Key
- translationalpsychiatry
- journal Label
- Translational Psychiatry
- chapter Entries
- title
- Distinct saliva DNA methylation profiles in relation to treatment outcome in youth with posttraumatic stress disorder.
- journal
- Translational Psychiatry
- year
- 2024
- authors
- Ensink JBM, Henneman P, Venema A, Zantvoord JB, den Kelder RO, Mannens MMAM, Lindauer RJL.
- design
- Longitudinal DNA-methylation study
- urls
https://pmc.ncbi.nlm.nih.gov/articles/PMC11282249/ · https://pubmed.ncbi.nlm.nih.gov/39060246/ · https://doi.org/10.1038/s41398-024-02892-1
- doi
- 10.1038/s41398-024-02892-1
- pmid
- 39060246
- targets
C18orf63 · CRHR2 · NUP35
- categories
Epigenetics · Clinical & self-report
- citation Count
- 7
- citation Snapshot
- count
- 7
- source
- Crossref
- retrieved At
- 2026-10-23
- study Design Assessment
- category
- observational
- peer Reviewed
- true
- basis
- Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/39060246/ · https://doi.org/10.1038/s41398-024-02892-1
- reviewed At
- 2026-10-23
- evidence
- evidence Type
- Epigenetics
- measured Genes
C18orf63 · CRHR2 · NUP35
- relationship Note
- Treatment combined evidence from EMDR and trauma-focused CBT. Saliva findings do not establish a brain-tissue effect or isolate eye movements.
- record Id
- pmid-39060246
- quotes
- None recorded
- source Pages
- None recorded
- summary
- The study included 46 young people with PTSD and 41 trauma-exposed controls, aged 8–18. Saliva DNA-methylation differences associated with treatment response included C18orf63 and the stress-related CRHR2 locus.
- limitation
- Treatment combined evidence from EMDR and trauma-focused CBT. Saliva findings do not establish a brain-tissue effect or isolate eye movements.
- id
- vision-epigenetics-pmid-39060246
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/39060246/ · https://doi.org/10.1038/s41398-024-02892-1
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- publication Key
- doi:10.1038/s41398-024-02892-1
- collection
- vision
- chapter Number
- 4
- topic Id
- epigenetics
- topic Title
- EMDR and trauma-focused psychotherapy: DNA methylation
- trust Score
- 1
- evidence
- evidence Type
- Epigenetics
- measured Genes
C18orf63 · CRHR2 · NUP35
- relationship Note
- Treatment combined evidence from EMDR and trauma-focused CBT. Saliva findings do not establish a brain-tissue effect or isolate eye movements.
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- id
- ptsd
- evidence
- field
- title
- text
- Distinct saliva DNA methylation profiles in relation to treatment outcome in youth with posttraumatic stress disorder.
- matched Text
- posttraumatic stress
- id
- trauma
- evidence
- field
- title
- text
- Distinct saliva DNA methylation profiles in relation to treatment outcome in youth with posttraumatic stress disorder.
- matched Text
- posttraumatic
- id
- stress
- evidence
- field
- title
- text
- Distinct saliva DNA methylation profiles in relation to treatment outcome in youth with posttraumatic stress disorder.
- matched Text
- stress
- conditions
ptsd · trauma · stress
- topic Trust Scores
1
- full Text
- status
- open-license
- retrieval Available
- true
- url
- https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11282249/fullTextXML
- pmcid
- PMC11282249
- rights
- license
- https://creativecommons.org/licenses/by/4.0/
- statement
© The Author(s) 2024 2024 https://creativecommons.org/licenses/by/4.0/ Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ .
- sha256
- 789b9f25b939251e36260059985a3fbb40958fc79982de34d1e908ac81818a69
- checked At
- 2026-10-24