40 Hz light flickering facilitates the glymphatic flow via adenosine signaling in mice
Sun X, Dias L, Peng C, Zhang Z, Ge H, Wang Z, Jin J, Jia M, Xu T, Guo W, Zheng W, He Y, Wu Y, Cai X, Agostinho P, Qu J, Cunha RA, Zhou X, Bai R, Chen JF. · Cell Discovery · 2024 · Controlled mouse visual-stimulation experiments
Original publication · Original publication · Original publication
Recorded summary
40 Hz flickering light increased glymphatic influx and efflux in mice. Genetic and pharmacological tests implicated adenosine A2A receptor signalling and aquaporin-4.
Recorded limitations
This measures physiological and signalling mechanisms in mice. It does not establish OXTR transcription changes or a safe, effective human visual protocol.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Controlled mouse visual-stimulation experiments
- assessment
- Not recorded
- trust Factor
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-applicable
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/39103336/ · https://doi.org/10.1038/s41421-024-00701-z
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- Not recorded
Topics and recorded topic scores
None recordedCitation snapshot and identifiers
- id
- pmid-39103336
- doi
- 10.1038/s41421-024-00701-z
- pmid
- 39103336
- citation Snapshot
- Not recorded
- citations By Collection
- vision
- Not recorded
Complete approved library record
- id
- pmid-39103336
- publication Key
- Not recorded
- aliases
- None recorded
- title
- 40 Hz light flickering facilitates the glymphatic flow via adenosine signaling in mice
- journal
- Cell Discovery
- publisher Family
- nature
- publisher Family Label
- Nature Portfolio
- neurotransmitters
- None recorded
- year
- 2024
- authors
- Sun X, Dias L, Peng C, Zhang Z, Ge H, Wang Z, Jin J, Jia M, Xu T, Guo W, Zheng W, He Y, Wu Y, Cai X, Agostinho P, Qu J, Cunha RA, Zhou X, Bai R, Chen JF.
- design
- Controlled mouse visual-stimulation experiments
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1038/s41421-024-00701-z
- pmid
- 39103336
- urls
https://doi.org/10.1038/s41421-024-00701-z · https://pmc.ncbi.nlm.nih.gov/articles/PMC11300858/ · https://pubmed.ncbi.nlm.nih.gov/39103336/
- collections
vision
- categories
Brain & nervous system · Molecular biomarkers
- targets
- None recorded
- priority
- 1
- quotes
- None recorded
- summary
- 40 Hz flickering light increased glymphatic influx and efflux in mice. Genetic and pharmacological tests implicated adenosine A2A receptor signalling and aquaporin-4.
- limitation
- This measures physiological and signalling mechanisms in mice. It does not establish OXTR transcription changes or a safe, effective human visual protocol.
- citation Count
- Not recorded
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-applicable
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/39103336/ · https://doi.org/10.1038/s41421-024-00701-z
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- vision
- Not recorded
- topics
- None recorded
- journal Key
- celldiscovery
- journal Label
- Cell Discovery
- chapter Entries
- None recorded
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
- None recorded
- full Text
- status
- open-license
- retrieval Available
- true
- url
- https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11300858/fullTextXML
- pmcid
- PMC11300858
- rights
- license
- https://creativecommons.org/licenses/by/4.0/
- statement
© The Author(s) 2024 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ .
- sha256
- 686a93c92e6b55279a3d0c352166171e36bed7e3e257a64ced8b990a274fcf07
- checked At
- 2026-10-24