Longitudinal DNA methylation in parent-infant pairs impacted by intergenerational social adversity: An RCT of the Michigan Model of Infant Mental Health Home Visiting
Petroff RL, Jester J, Riggs J, Alfafara E, Springer K, Kerr N, Issa M, Hall A, Rosenblum K, Goodrich JM, Muzik M, Michigan Collaborative for Infant Mental Health Research. · Brain and behavior · 2024 · Randomized parent–infant psychotherapy trial
Original publication · Original publication · Original publication
Recorded summary
Infant BDNF methylation showed a possible decrease after the home-visiting psychotherapy programme. Most maternal molecular associations and intervention effects were absent.
Recorded limitations
The intervention includes multiple relational components. The results do not isolate particular spoken words, and the molecular findings were mixed.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Randomized parent–infant psychotherapy trial
- assessment
- Not recorded
- trust Factor
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Randomized controlled design recorded in the publication-specific design or bibliographic indexing.
- sources
https://pubmed.ncbi.nlm.nih.gov/39295112/ · https://doi.org/10.1002/brb3.70035
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- Not recorded
Topics and recorded topic scores
None recordedCitation snapshot and identifiers
- id
- pmid-39295112
- doi
- 10.1002/brb3.70035
- pmid
- 39295112
- citation Snapshot
- Not recorded
- citations By Collection
- language
- Not recorded
Complete approved library record
- id
- pmid-39295112
- publication Key
- Not recorded
- aliases
- None recorded
- title
- Longitudinal DNA methylation in parent-infant pairs impacted by intergenerational social adversity: An RCT of the Michigan Model of Infant Mental Health Home Visiting
- journal
- Brain and behavior
- neurotransmitters
- None recorded
- year
- 2024
- authors
- Petroff RL, Jester J, Riggs J, Alfafara E, Springer K, Kerr N, Issa M, Hall A, Rosenblum K, Goodrich JM, Muzik M, Michigan Collaborative for Infant Mental Health Research.
- design
- Randomized parent–infant psychotherapy trial
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1002/brb3.70035
- pmid
- 39295112
- urls
https://pmc.ncbi.nlm.nih.gov/articles/PMC11410872/ · https://pubmed.ncbi.nlm.nih.gov/39295112/ · https://doi.org/10.1002/brb3.70035
- collections
language
- categories
Epigenetics
- targets
NR3C1 · SLC6A4 · BDNF
- priority
- 0
- quotes
- None recorded
- summary
- Infant BDNF methylation showed a possible decrease after the home-visiting psychotherapy programme. Most maternal molecular associations and intervention effects were absent.
- limitation
- The intervention includes multiple relational components. The results do not isolate particular spoken words, and the molecular findings were mixed.
- citation Count
- Not recorded
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Randomized controlled design recorded in the publication-specific design or bibliographic indexing.
- sources
https://pubmed.ncbi.nlm.nih.gov/39295112/ · https://doi.org/10.1002/brb3.70035
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- language
- Not recorded
- topics
- None recorded
- journal Key
- brainandbehavior
- journal Label
- Brain and behavior
- chapter Entries
- None recorded
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
- None recorded
- full Text
- status
- open-license
- retrieval Available
- true
- url
- https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11410872/fullTextXML
- pmcid
- PMC11410872
- rights
- license
- https://creativecommons.org/licenses/by/4.0/
- statement
© 2024 The Author(s). Brain and Behavior published by Wiley Periodicals LLC. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- sha256
- f853cc1c29d1e3746b5ffe9b1ca6846c33e61b9110f6c9f6680fce0750489d82
- checked At
- 2026-10-24