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The Moderating Role of Genetics on the Effectiveness of the Mindfulness-Based Stress Reduction for Breast Cancer (MBSR(BC)) Program on Cognitive Impairment.

Park JY, Lengacher CA, Rodriguez CS, Meng H, Kip KE, Morgan S, Joshi A, Hueluer G, Wang JR, Tinsley S, Cox C, Kiluk J, Donovan KA, Moscoso M, Bornstein E, Lucas JM, Fonseca T, Krothapalli M, Padgett LS, Nidamanur S, Hornback E, Patel D, Chamkeri R, Reich RR. · Biological research for nursing · 2025 · Exploratory genetic analysis of a randomized trial

Original publication · Original publication

Recorded summary

In 128 breast-cancer survivors randomised to MBSR or education/support, variants including DRD2 rs6277 were associated with differences in cognitive response to the intervention.

Recorded limitations

This was a small exploratory moderator analysis across multiple variants. It measured genotype, not altered gene expression, and is not a validated genetic predictor of treatment response.

Evidence and provenance

Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.

Study design and assessment
design
Exploratory genetic analysis of a randomized trial
assessment
category
peer-reviewed
peer Reviewed
true
basis
Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
sources

https://pubmed.ncbi.nlm.nih.gov/39413359/ · https://doi.org/10.1177/10998004241289629

assessed At
2026-10-26
registered Masking Basis
false
trust Factor
score
2
scope
Paper
status
assessed
randomized Controlled Trial
true
blinding
not-confirmed
peer Reviewed
true
basis
Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
sources

https://pubmed.ncbi.nlm.nih.gov/39413359/ · https://doi.org/10.1177/10998004241289629

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
jadad
status
unassessed
score
Not recorded
evidence
intervention
MBSR
comparator
Education/support
evidence Type
Genetics & genomics
source URLs

https://pubmed.ncbi.nlm.nih.gov/39413359/ · https://doi.org/10.1177/10998004241289629

checked At
2026-10-26
review Scope
Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
discovery Sources

https://europepmc.org/article/MED/39413359

selection Policy
Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
measurement
Genotype moderation of cognitive response; not gene expression
measured Genes

DRD2 · COMT · ANKK1

sample
128 breast-cancer survivors
relationship Note
NCT02786797; exploratory genetic moderator analysis
trial Id
NCT02786797
Topics and recorded topic scores
  1. key
    language:mindfulness-epigenetics
    title
    Mindfulness, DNA methylation and genetic variation
    collection
    language
    trust Score
    1
Citation snapshot and identifiers
id
pmid-39413359
doi
10.1177/10998004241289629
pmid
39413359
citation Snapshot
count
4
source
Europe PMC
retrieved At
2026-10-26
url
https://europepmc.org/article/MED/39413359
citations By Collection
language
4
Complete approved library record
id
pmid-39413359
publication Key
doi:10.1177/10998004241289629
aliases
None recorded
title
The Moderating Role of Genetics on the Effectiveness of the Mindfulness-Based Stress Reduction for Breast Cancer (MBSR(BC)) Program on Cognitive Impairment.
journal
Biological research for nursing
neurotransmitters
None recorded
year
2025
authors
Park JY, Lengacher CA, Rodriguez CS, Meng H, Kip KE, Morgan S, Joshi A, Hueluer G, Wang JR, Tinsley S, Cox C, Kiluk J, Donovan KA, Moscoso M, Bornstein E, Lucas JM, Fonseca T, Krothapalli M, Padgett LS, Nidamanur S, Hornback E, Patel D, Chamkeri R, Reich RR.
design
Exploratory genetic analysis of a randomized trial
identity Conflict
Not recorded
doi
10.1177/10998004241289629
pmid
39413359
urls

https://pubmed.ncbi.nlm.nih.gov/39413359/ · https://doi.org/10.1177/10998004241289629

collections

language

categories

Genetics & genomics

targets

DRD2 · COMT · ANKK1

priority
0
quotes
None recorded
summary
In 128 breast-cancer survivors randomised to MBSR or education/support, variants including DRD2 rs6277 were associated with differences in cognitive response to the intervention.
limitation
This was a small exploratory moderator analysis across multiple variants. It measured genotype, not altered gene expression, and is not a validated genetic predictor of treatment response.
citation Count
4
citation Snapshot
count
4
source
Europe PMC
retrieved At
2026-10-26
url
https://europepmc.org/article/MED/39413359
study Design Assessment
category
peer-reviewed
peer Reviewed
true
basis
Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
sources

https://pubmed.ncbi.nlm.nih.gov/39413359/ · https://doi.org/10.1177/10998004241289629

assessed At
2026-10-26
registered Masking Basis
false
paper Trust Assessment
score
2
scope
Paper
status
assessed
randomized Controlled Trial
true
blinding
not-confirmed
peer Reviewed
true
basis
Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
sources

https://pubmed.ncbi.nlm.nih.gov/39413359/ · https://doi.org/10.1177/10998004241289629

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
citations By Collection
language
4
topics
  1. key
    language:mindfulness-epigenetics
    title
    Mindfulness, DNA methylation and genetic variation
    collection
    language
    trust Score
    1
journal Key
biologicalresearchfornursing
journal Label
Biological research for nursing
chapter Entries
  1. title
    The Moderating Role of Genetics on the Effectiveness of the Mindfulness-Based Stress Reduction for Breast Cancer (MBSR(BC)) Program on Cognitive Impairment.
    journal
    Biological research for nursing
    year
    2025
    authors
    Park JY, Lengacher CA, Rodriguez CS, Meng H, Kip KE, Morgan S, Joshi A, Hueluer G, Wang JR, Tinsley S, Cox C, Kiluk J, Donovan KA, Moscoso M, Bornstein E, Lucas JM, Fonseca T, Krothapalli M, Padgett LS, Nidamanur S, Hornback E, Patel D, Chamkeri R, Reich RR.
    design
    Exploratory genetic analysis of a randomized trial
    urls

    https://pubmed.ncbi.nlm.nih.gov/39413359/ · https://doi.org/10.1177/10998004241289629

    doi
    10.1177/10998004241289629
    pmid
    39413359
    targets

    DRD2 · COMT · ANKK1

    categories

    Genetics & genomics

    citation Count
    4
    citation Snapshot
    count
    4
    source
    Europe PMC
    retrieved At
    2026-10-26
    url
    https://europepmc.org/article/MED/39413359
    study Design Assessment
    category
    peer-reviewed
    peer Reviewed
    true
    basis
    Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
    sources

    https://pubmed.ncbi.nlm.nih.gov/39413359/ · https://doi.org/10.1177/10998004241289629

    assessed At
    2026-10-26
    registered Masking Basis
    false
    evidence
    intervention
    MBSR
    comparator
    Education/support
    evidence Type
    Genetics & genomics
    source URLs

    https://pubmed.ncbi.nlm.nih.gov/39413359/ · https://doi.org/10.1177/10998004241289629

    checked At
    2026-10-26
    review Scope
    Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
    discovery Sources

    https://europepmc.org/article/MED/39413359

    selection Policy
    Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
    measurement
    Genotype moderation of cognitive response; not gene expression
    measured Genes

    DRD2 · COMT · ANKK1

    sample
    128 breast-cancer survivors
    relationship Note
    NCT02786797; exploratory genetic moderator analysis
    trial Id
    NCT02786797
    id
    language-mindfulness-epigenetics-pmid-39413359
    record Id
    pmid-39413359
    quotes
    None recorded
    source Pages
    None recorded
    summary
    In 128 breast-cancer survivors randomised to MBSR or education/support, variants including DRD2 rs6277 were associated with differences in cognitive response to the intervention.
    limitation
    This was a small exploratory moderator analysis across multiple variants. It measured genotype, not altered gene expression, and is not a validated genetic predictor of treatment response.
    paper Trust Assessment
    score
    2
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    true
    blinding
    not-confirmed
    peer Reviewed
    true
    basis
    Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
    sources

    https://pubmed.ncbi.nlm.nih.gov/39413359/ · https://doi.org/10.1177/10998004241289629

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    publication Key
    doi:10.1177/10998004241289629
    collection
    language
    chapter Number
    4
    topic Id
    mindfulness-epigenetics
    topic Title
    Mindfulness, DNA methylation and genetic variation
    trust Score
    1
evidence
intervention
MBSR
comparator
Education/support
evidence Type
Genetics & genomics
source URLs

https://pubmed.ncbi.nlm.nih.gov/39413359/ · https://doi.org/10.1177/10998004241289629

checked At
2026-10-26
review Scope
Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
discovery Sources

https://europepmc.org/article/MED/39413359

selection Policy
Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
measurement
Genotype moderation of cognitive response; not gene expression
measured Genes

DRD2 · COMT · ANKK1

sample
128 breast-cancer survivors
relationship Note
NCT02786797; exploratory genetic moderator analysis
trial Id
NCT02786797
jadad
status
unassessed
score
Not recorded
condition Evidence
None recorded
conditions
None recorded
topic Trust Scores

1

full Text
status
not-indexed
retrieval Available
false

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