Epigenetic markers of disease risk and psychotherapy response in anxiety disorders - a longitudinal analysis of the DNA methylome
Domschke K, Schiele MA, Crespo Salvador Ó, Zillich L, Lipovsek J, Pittig A, Heinig I, Ridderbusch IC, Straube B, Richter J, Hollandt M, Plag J, Fydrich T, Koelkebeck K, Weber H, Lueken U, Dannlowski U, Margraf J, Schneider S, Binder EB, Ströhle A, Rief W, Kircher T, Pauli P, Hamm A, Arolt V, Hoyer J, Wittchen HU, Erhardt-Lehmann A, Köttgen A, Schlosser P, Deckert J. · Molecular Psychiatry · 2025 · Longitudinal epigenome-wide association study
Original publication · Original publication · Original publication
Recorded summary
The study identified disease-associated methylation sites and suggestive baseline predictors and longitudinal changes related to psychotherapy response.
Recorded limitations
Treatment-response signals were suggestive rather than definitive epigenome-wide findings. Association does not establish that verbal communication caused the molecular changes.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Longitudinal epigenome-wide association study
- assessment
- Not recorded
- trust Factor
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/40281224/ · https://doi.org/10.1038/s41380-025-03038-5
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- Not recorded
Topics and recorded topic scores
None recordedCitation snapshot and identifiers
- id
- pmid-40281224
- doi
- 10.1038/s41380-025-03038-5
- pmid
- 40281224
- citation Snapshot
- Not recorded
- citations By Collection
- language
- Not recorded
Complete approved library record
- id
- pmid-40281224
- publication Key
- Not recorded
- aliases
- None recorded
- title
- Epigenetic markers of disease risk and psychotherapy response in anxiety disorders - a longitudinal analysis of the DNA methylome
- journal
- Molecular Psychiatry
- publisher Family
- nature
- publisher Family Label
- Nature Portfolio
- neurotransmitters
- None recorded
- year
- 2025
- authors
- Domschke K, Schiele MA, Crespo Salvador Ó, Zillich L, Lipovsek J, Pittig A, Heinig I, Ridderbusch IC, Straube B, Richter J, Hollandt M, Plag J, Fydrich T, Koelkebeck K, Weber H, Lueken U, Dannlowski U, Margraf J, Schneider S, Binder EB, Ströhle A, Rief W, Kircher T, Pauli P, Hamm A, Arolt V, Hoyer J, Wittchen HU, Erhardt-Lehmann A, Köttgen A, Schlosser P, Deckert J.
- design
- Longitudinal epigenome-wide association study
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1038/s41380-025-03038-5
- pmid
- 40281224
- urls
https://doi.org/10.1038/s41380-025-03038-5 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12436192/ · https://pubmed.ncbi.nlm.nih.gov/40281224/
- collections
language
- categories
Epigenetics
- targets
- None recorded
- priority
- 0
- quotes
- None recorded
- summary
- The study identified disease-associated methylation sites and suggestive baseline predictors and longitudinal changes related to psychotherapy response.
- limitation
- Treatment-response signals were suggestive rather than definitive epigenome-wide findings. Association does not establish that verbal communication caused the molecular changes.
- citation Count
- Not recorded
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/40281224/ · https://doi.org/10.1038/s41380-025-03038-5
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- language
- Not recorded
- topics
- None recorded
- journal Key
- molecularpsychiatry
- journal Label
- Molecular Psychiatry
- chapter Entries
- None recorded
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- id
- anxiety
- evidence
- field
- title
- text
- Epigenetic markers of disease risk and psychotherapy response in anxiety disorders - a longitudinal analysis of the DNA methylome
- matched Text
- anxiety
- conditions
anxiety
- topic Trust Scores
- None recorded
- full Text
- status
- open-license
- retrieval Available
- true
- url
- https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12436192/fullTextXML
- pmcid
- PMC12436192
- rights
- license
- https://creativecommons.org/licenses/by/4.0/
- statement
© The Author(s) 2025 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ .
- sha256
- 752e87f16baee8dedbc72026401a108848fa79881020c83a7557b89b4e6ae110
- checked At
- 2026-10-24