Mindfulness-based cognitive therapy versus treatment as usual after non-remission with NHS Talking Therapies high-intensity psychological therapy for depression: a UK-based clinical effectiveness and cost-effectiveness randomised, controlled, superiority trial
Barnhofer T, Dunn BD, Strauss C, Ruths FA, Barrett B, Ryan M, Ladwa A, Stafford F, Fichera R, Baber H, McGuinness A, Metcalfe I, Kan DKY, Pooley J, Harding D, Tassie E, Carson J, Rhodes S, Young AH, Connors J, Warren FC. · The lancet. Psychiatry · 2025 · Randomized controlled trial; masked statistical analysis
Original publication · Original publication · Original publication
Recorded summary
In RESPOND, MBCT plus usual care reduced depression symptoms more than usual care at 34 weeks: an adjusted PHQ-9 difference of −2.49 points (95% CI −3.89 to −1.09).
Recorded limitations
The control received usual care rather than a matched group intervention. The study assesses symptoms and costs; it does not test gene expression.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Randomized controlled trial; masked statistical analysis
- assessment
- basis
- Participants and therapists were unmasked, and follow-up outcomes were self-reported electronically. Masked statistical analysis alone is not treated as single-blind outcome assessment.
- sources
https://pmc.ncbi.nlm.nih.gov/articles/PMC12078190/ · https://pubmed.ncbi.nlm.nih.gov/40379363/ · https://doi.org/10.1016/s2215-0366(25)00105-1
- assessed At
- 2026-10-23
- registered Masking Basis
- false
- category
- peer-reviewed
- peer Reviewed
- true
- trust Factor
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Participants and therapists were unmasked, and follow-up outcomes were self-reported electronically. Masked statistical analysis alone is not treated as single-blind outcome assessment.
- sources
https://pubmed.ncbi.nlm.nih.gov/40379363/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC12078190/ · https://doi.org/10.1016/s2215-0366(25)00105-1
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- intervention
- MBCT plus usual care
- comparator
- Usual care
- sample
- 234 adults with depression persisting after psychological therapy
- measurement
- PHQ-9 depression symptoms
- timing
- 8-week course; primary endpoint at 34 weeks
- trial Id
- ISRCTN17755571
- measured Genes
- None recorded
- pathways
- None recorded
- evidence Type
- Clinical outcomes
- source URLs
https://pmc.ncbi.nlm.nih.gov/articles/PMC12078190/ · https://pubmed.ncbi.nlm.nih.gov/40379363/ · https://doi.org/10.1016/s2215-0366(25)00105-1
- checked At
- 2026-10-23
- review Scope
- Publication abstract and selected full-text methods; Jadad assessment pending
Topics and recorded topic scores
- key
- language:mindfulness-clinical
- title
- Mindfulness-based interventions: controlled clinical trials
- collection
- language
- trust Score
- 2
Citation snapshot and identifiers
- id
- pmid-40379363
- doi
- 10.1016/s2215-0366(25)00105-1
- pmid
- 40379363
- citation Snapshot
- count
- 16
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1016/s2215-0366(25)00105-1
- citations By Collection
- language
- 16
Complete approved library record
- id
- pmid-40379363
- aliases
- None recorded
- title
- Mindfulness-based cognitive therapy versus treatment as usual after non-remission with NHS Talking Therapies high-intensity psychological therapy for depression: a UK-based clinical effectiveness and cost-effectiveness randomised, controlled, superiority trial
- journal
- The lancet. Psychiatry
- neurotransmitters
- None recorded
- year
- 2025
- authors
- Barnhofer T, Dunn BD, Strauss C, Ruths FA, Barrett B, Ryan M, Ladwa A, Stafford F, Fichera R, Baber H, McGuinness A, Metcalfe I, Kan DKY, Pooley J, Harding D, Tassie E, Carson J, Rhodes S, Young AH, Connors J, Warren FC.
- design
- Randomized controlled trial; masked statistical analysis
- identity Conflict
- Not recorded
- doi
- 10.1016/s2215-0366(25)00105-1
- pmid
- 40379363
- urls
https://pmc.ncbi.nlm.nih.gov/articles/PMC12078190/ · https://pubmed.ncbi.nlm.nih.gov/40379363/ · https://doi.org/10.1016/s2215-0366(25)00105-1
- collections
language
- categories
Clinical & self-report
- targets
- None recorded
- priority
- 1
- quotes
- None recorded
- summary
- In RESPOND, MBCT plus usual care reduced depression symptoms more than usual care at 34 weeks: an adjusted PHQ-9 difference of −2.49 points (95% CI −3.89 to −1.09).
- limitation
- The control received usual care rather than a matched group intervention. The study assesses symptoms and costs; it does not test gene expression.
- citation Count
- 16
- citation Snapshot
- count
- 16
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1016/s2215-0366(25)00105-1
- study Design Assessment
- basis
- Participants and therapists were unmasked, and follow-up outcomes were self-reported electronically. Masked statistical analysis alone is not treated as single-blind outcome assessment.
- sources
https://pmc.ncbi.nlm.nih.gov/articles/PMC12078190/ · https://pubmed.ncbi.nlm.nih.gov/40379363/ · https://doi.org/10.1016/s2215-0366(25)00105-1
- assessed At
- 2026-10-23
- registered Masking Basis
- false
- category
- peer-reviewed
- peer Reviewed
- true
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Participants and therapists were unmasked, and follow-up outcomes were self-reported electronically. Masked statistical analysis alone is not treated as single-blind outcome assessment.
- sources
https://pubmed.ncbi.nlm.nih.gov/40379363/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC12078190/ · https://doi.org/10.1016/s2215-0366(25)00105-1
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- language
- 16
- topics
- key
- language:mindfulness-clinical
- title
- Mindfulness-based interventions: controlled clinical trials
- collection
- language
- trust Score
- 2
- journal Key
- lancetpsychiatry
- journal Label
- The lancet. Psychiatry
- chapter Entries
- id
- language-mindfulness-clinical-pmid-40379363
- record Id
- pmid-40379363
- title
- Mindfulness-based cognitive therapy versus treatment as usual after non-remission with NHS Talking Therapies high-intensity psychological therapy for depression: a UK-based clinical effectiveness and cost-effectiveness randomised, controlled, superiority trial
- journal
- The lancet. Psychiatry
- year
- 2025
- authors
- Barnhofer T, Dunn BD, Strauss C, Ruths FA, Barrett B, Ryan M, Ladwa A, Stafford F, Fichera R, Baber H, McGuinness A, Metcalfe I, Kan DKY, Pooley J, Harding D, Tassie E, Carson J, Rhodes S, Young AH, Connors J, Warren FC.
- design
- Randomized controlled trial; masked statistical analysis
- urls
https://pmc.ncbi.nlm.nih.gov/articles/PMC12078190/ · https://pubmed.ncbi.nlm.nih.gov/40379363/ · https://doi.org/10.1016/s2215-0366(25)00105-1
- quotes
- None recorded
- summary
- In RESPOND, MBCT plus usual care reduced depression symptoms more than usual care at 34 weeks: an adjusted PHQ-9 difference of −2.49 points (95% CI −3.89 to −1.09).
- limitation
- The control received usual care rather than a matched group intervention. The study assesses symptoms and costs; it does not test gene expression.
- citation Count
- 16
- citation Snapshot
- count
- 16
- source
- Crossref
- retrieved At
- 2026-10-23
- url
- https://api.crossref.org/works/10.1016/s2215-0366(25)00105-1
- study Design Assessment
- basis
- Participants and therapists were unmasked, and follow-up outcomes were self-reported electronically. Masked statistical analysis alone is not treated as single-blind outcome assessment.
- sources
https://pmc.ncbi.nlm.nih.gov/articles/PMC12078190/ · https://pubmed.ncbi.nlm.nih.gov/40379363/ · https://doi.org/10.1016/s2215-0366(25)00105-1
- assessed At
- 2026-10-23
- registered Masking Basis
- false
- category
- peer-reviewed
- peer Reviewed
- true
- source Pages
- None recorded
- targets
- None recorded
- categories
Clinical & self-report
- doi
- 10.1016/s2215-0366(25)00105-1
- pmid
- 40379363
- evidence
- intervention
- MBCT plus usual care
- comparator
- Usual care
- sample
- 234 adults with depression persisting after psychological therapy
- measurement
- PHQ-9 depression symptoms
- timing
- 8-week course; primary endpoint at 34 weeks
- trial Id
- ISRCTN17755571
- measured Genes
- None recorded
- pathways
- None recorded
- evidence Type
- Clinical outcomes
- source URLs
https://pmc.ncbi.nlm.nih.gov/articles/PMC12078190/ · https://pubmed.ncbi.nlm.nih.gov/40379363/ · https://doi.org/10.1016/s2215-0366(25)00105-1
- checked At
- 2026-10-23
- review Scope
- Publication abstract and selected full-text methods; Jadad assessment pending
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Participants and therapists were unmasked, and follow-up outcomes were self-reported electronically. Masked statistical analysis alone is not treated as single-blind outcome assessment.
- sources
https://pubmed.ncbi.nlm.nih.gov/40379363/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC12078190/ · https://doi.org/10.1016/s2215-0366(25)00105-1
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- collection
- language
- chapter Number
- 4
- topic Id
- mindfulness-clinical
- topic Title
- Mindfulness-based interventions: controlled clinical trials
- trust Score
- 2
- evidence
- intervention
- MBCT plus usual care
- comparator
- Usual care
- sample
- 234 adults with depression persisting after psychological therapy
- measurement
- PHQ-9 depression symptoms
- timing
- 8-week course; primary endpoint at 34 weeks
- trial Id
- ISRCTN17755571
- measured Genes
- None recorded
- pathways
- None recorded
- evidence Type
- Clinical outcomes
- source URLs
https://pmc.ncbi.nlm.nih.gov/articles/PMC12078190/ · https://pubmed.ncbi.nlm.nih.gov/40379363/ · https://doi.org/10.1016/s2215-0366(25)00105-1
- checked At
- 2026-10-23
- review Scope
- Publication abstract and selected full-text methods; Jadad assessment pending
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- id
- depression
- evidence
- field
- title
- text
- Mindfulness-based cognitive therapy versus treatment as usual after non-remission with NHS Talking Therapies high-intensity psychological therapy for depression: a UK-based clinical effectiveness and cost-effectiveness randomised, controlled, superiority trial
- matched Text
- depression
- field
- evidence.sample
- text
- 234 adults with depression persisting after psychological therapy
- matched Text
- depression
- field
- evidence.measurement
- text
- PHQ-9 depression symptoms
- matched Text
- depression
- conditions
depression
- topic Trust Scores
2
- full Text
- status
- open-license
- retrieval Available
- true
- url
- https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12078190/fullTextXML
- pmcid
- PMC12078190
- rights
- license
- http://creativecommons.org/licenses/by/4.0/
- statement
© 2025 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- sha256
- 14d5527530e20769c785745db9f9c70beab9456939512aa44000cd53b09d44bb
- checked At
- 2026-10-24