PCC-hippocampal functional connectivity associated with stress biomarker changes after meditation training for healthy adults.
Joss D, Sevinc G, Denninger JW, Khalsa SBS, Hoge EA, Bhasin M, Dusek JA, Macklin E, Libermann TA, Fricchione GL, Benson H, Lazar SW. · Neuroscience letters · 2025 · Secondary imaging and transcriptomic analysis of a randomized trial
Original publication · Original publication · Original publication
Recorded summary
A 94-person subset of a meditation, yoga and education trial linked changes in brain connectivity with stress-related measures and inflammatory gene-regulation signals, informing hypotheses about mind-body pathways.
Recorded limitations
This is a secondary analysis of NCT01308970, also represented by PMID 41020112 in the library. Associations between connectivity and molecular measures do not establish causal mediation or an independent trial replication.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Secondary imaging and transcriptomic analysis of a randomized trial
- assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/40414454/ · https://doi.org/10.1016/j.neulet.2025.138272 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12287978/
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- trust Factor
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/40414454/ · https://doi.org/10.1016/j.neulet.2025.138272 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12287978/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- intervention
- Eight-week meditation, yoga or education
- comparator
- Yoga and education arms of the same parent trial
- evidence Type
- Gene expression
- source URLs
https://pubmed.ncbi.nlm.nih.gov/40414454/ · https://doi.org/10.1016/j.neulet.2025.138272 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12287978/
- checked At
- 2026-10-26
- review Scope
- Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
- discovery Sources
https://europepmc.org/article/MED/40414454
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
- measurement
- Brain connectivity and stress-related transcriptional regulation
- measured Genes
- None recorded
- sample
- 94 participants in a parent-trial subset
- relationship Note
- NCT01308970; parent-trial overlap with PMID 41020112
Topics and recorded topic scores
- key
- language:mindfulness-rna
- title
- Mindfulness interventions and gene expression
- collection
- language
- trust Score
- 2
Citation snapshot and identifiers
- id
- pmid-40414454
- doi
- 10.1016/j.neulet.2025.138272
- pmid
- 40414454
- citation Snapshot
- count
- 1
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/40414454
- citations By Collection
- language
- 1
Complete approved library record
- id
- pmid-40414454
- publication Key
- doi:10.1016/j.neulet.2025.138272
- aliases
- None recorded
- title
- PCC-hippocampal functional connectivity associated with stress biomarker changes after meditation training for healthy adults.
- journal
- Neuroscience letters
- neurotransmitters
- None recorded
- year
- 2025
- authors
- Joss D, Sevinc G, Denninger JW, Khalsa SBS, Hoge EA, Bhasin M, Dusek JA, Macklin E, Libermann TA, Fricchione GL, Benson H, Lazar SW.
- design
- Secondary imaging and transcriptomic analysis of a randomized trial
- identity Conflict
- Not recorded
- doi
- 10.1016/j.neulet.2025.138272
- pmid
- 40414454
- urls
https://pubmed.ncbi.nlm.nih.gov/40414454/ · https://doi.org/10.1016/j.neulet.2025.138272 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12287978/
- collections
language
- categories
Gene expression · Brain & nervous system
- targets
- None recorded
- priority
- 0
- quotes
- None recorded
- summary
- A 94-person subset of a meditation, yoga and education trial linked changes in brain connectivity with stress-related measures and inflammatory gene-regulation signals, informing hypotheses about mind-body pathways.
- limitation
- This is a secondary analysis of NCT01308970, also represented by PMID 41020112 in the library. Associations between connectivity and molecular measures do not establish causal mediation or an independent trial replication.
- citation Count
- 1
- citation Snapshot
- count
- 1
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/40414454
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/40414454/ · https://doi.org/10.1016/j.neulet.2025.138272 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12287978/
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/40414454/ · https://doi.org/10.1016/j.neulet.2025.138272 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12287978/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- language
- 1
- topics
- key
- language:mindfulness-rna
- title
- Mindfulness interventions and gene expression
- collection
- language
- trust Score
- 2
- journal Key
- neuroscienceletters
- journal Label
- Neuroscience letters
- chapter Entries
- title
- PCC-hippocampal functional connectivity associated with stress biomarker changes after meditation training for healthy adults.
- journal
- Neuroscience letters
- year
- 2025
- authors
- Joss D, Sevinc G, Denninger JW, Khalsa SBS, Hoge EA, Bhasin M, Dusek JA, Macklin E, Libermann TA, Fricchione GL, Benson H, Lazar SW.
- design
- Secondary imaging and transcriptomic analysis of a randomized trial
- urls
https://pubmed.ncbi.nlm.nih.gov/40414454/ · https://doi.org/10.1016/j.neulet.2025.138272 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12287978/
- doi
- 10.1016/j.neulet.2025.138272
- pmid
- 40414454
- targets
- None recorded
- categories
Gene expression · Brain & nervous system
- citation Count
- 1
- citation Snapshot
- count
- 1
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/40414454
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/40414454/ · https://doi.org/10.1016/j.neulet.2025.138272 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12287978/
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- evidence
- intervention
- Eight-week meditation, yoga or education
- comparator
- Yoga and education arms of the same parent trial
- evidence Type
- Gene expression
- source URLs
https://pubmed.ncbi.nlm.nih.gov/40414454/ · https://doi.org/10.1016/j.neulet.2025.138272 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12287978/
- checked At
- 2026-10-26
- review Scope
- Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
- discovery Sources
https://europepmc.org/article/MED/40414454
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
- measurement
- Brain connectivity and stress-related transcriptional regulation
- measured Genes
- None recorded
- sample
- 94 participants in a parent-trial subset
- relationship Note
- NCT01308970; parent-trial overlap with PMID 41020112
- id
- language-mindfulness-rna-pmid-40414454
- record Id
- pmid-40414454
- quotes
- None recorded
- source Pages
- None recorded
- summary
- A 94-person subset of a meditation, yoga and education trial linked changes in brain connectivity with stress-related measures and inflammatory gene-regulation signals, informing hypotheses about mind-body pathways.
- limitation
- This is a secondary analysis of NCT01308970, also represented by PMID 41020112 in the library. Associations between connectivity and molecular measures do not establish causal mediation or an independent trial replication.
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/40414454/ · https://doi.org/10.1016/j.neulet.2025.138272 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12287978/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- publication Key
- doi:10.1016/j.neulet.2025.138272
- collection
- language
- chapter Number
- 4
- topic Id
- mindfulness-rna
- topic Title
- Mindfulness interventions and gene expression
- trust Score
- 2
- evidence
- intervention
- Eight-week meditation, yoga or education
- comparator
- Yoga and education arms of the same parent trial
- evidence Type
- Gene expression
- source URLs
https://pubmed.ncbi.nlm.nih.gov/40414454/ · https://doi.org/10.1016/j.neulet.2025.138272 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12287978/
- checked At
- 2026-10-26
- review Scope
- Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
- discovery Sources
https://europepmc.org/article/MED/40414454
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
- measurement
- Brain connectivity and stress-related transcriptional regulation
- measured Genes
- None recorded
- sample
- 94 participants in a parent-trial subset
- relationship Note
- NCT01308970; parent-trial overlap with PMID 41020112
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
2
- full Text
- status
- not-indexed
- retrieval Available
- false