Effects of Auditory Frequency Stimulation on Balance and Rehabilitation Outcomes in Patients With Stroke: A Randomized Case-Control Study.
Chen R, Jin L, Song J, Dong J, Li Y. · Brain and behavior · 2025 · Randomized controlled pilot study
Original publication · Original publication · Original publication
Recorded summary
Among 27 stroke rehabilitation completers, the binaural-stimulation group improved daily-living and depression scores more than the music comparison group. Balance measures improved in both groups.
Recorded limitations
The small sample and combined rehabilitation context limit causal attribution to the beats. Correlations between functional measures do not prove a brain mechanism.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Randomized controlled pilot study
- assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/40621706/ · https://doi.org/10.1002/brb3.70671 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12230630/
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- trust Factor
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/40621706/ · https://doi.org/10.1002/brb3.70671 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12230630/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- intervention
- Binaural auditory stimulation during stroke rehabilitation
- comparator
- Music during rehabilitation
- evidence Type
- Clinical or experimental outcomes
- source URLs
https://pubmed.ncbi.nlm.nih.gov/40621706/ · https://doi.org/10.1002/brb3.70671 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12230630/
- checked At
- 2026-10-26
- review Scope
- Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
- discovery Sources
https://daytab.com/study/bmtv2256 · https://europepmc.org/article/MED/40621706
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
Topics and recorded topic scores
- key
- sound:i
- title
- Brain entrainment, pain, anxiety and heart-rate variability
- collection
- sound
- trust Score
- 3
Citation snapshot and identifiers
- id
- pmid-40621706
- doi
- 10.1002/brb3.70671
- pmid
- 40621706
- citation Snapshot
- count
- 1
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/40621706
- citations By Collection
- sound
- 1
Complete approved library record
- id
- pmid-40621706
- publication Key
- doi:10.1002/brb3.70671
- aliases
- None recorded
- title
- Effects of Auditory Frequency Stimulation on Balance and Rehabilitation Outcomes in Patients With Stroke: A Randomized Case-Control Study.
- journal
- Brain and behavior
- neurotransmitters
- None recorded
- year
- 2025
- authors
- Chen R, Jin L, Song J, Dong J, Li Y.
- design
- Randomized controlled pilot study
- identity Conflict
- Not recorded
- doi
- 10.1002/brb3.70671
- pmid
- 40621706
- urls
https://pubmed.ncbi.nlm.nih.gov/40621706/ · https://doi.org/10.1002/brb3.70671 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12230630/
- collections
sound
- categories
Clinical & self-report
- targets
- None recorded
- priority
- 1
- quotes
- None recorded
- summary
- Among 27 stroke rehabilitation completers, the binaural-stimulation group improved daily-living and depression scores more than the music comparison group. Balance measures improved in both groups.
- limitation
- The small sample and combined rehabilitation context limit causal attribution to the beats. Correlations between functional measures do not prove a brain mechanism.
- citation Count
- 1
- citation Snapshot
- count
- 1
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/40621706
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/40621706/ · https://doi.org/10.1002/brb3.70671 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12230630/
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/40621706/ · https://doi.org/10.1002/brb3.70671 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12230630/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- sound
- 1
- topics
- key
- sound:i
- title
- Brain entrainment, pain, anxiety and heart-rate variability
- collection
- sound
- trust Score
- 3
- journal Key
- brainandbehavior
- journal Label
- Brain and behavior
- chapter Entries
- title
- Effects of Auditory Frequency Stimulation on Balance and Rehabilitation Outcomes in Patients With Stroke: A Randomized Case-Control Study.
- journal
- Brain and behavior
- year
- 2025
- authors
- Chen R, Jin L, Song J, Dong J, Li Y.
- design
- Randomized controlled pilot study
- urls
https://pubmed.ncbi.nlm.nih.gov/40621706/ · https://doi.org/10.1002/brb3.70671 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12230630/
- doi
- 10.1002/brb3.70671
- pmid
- 40621706
- targets
- None recorded
- categories
Clinical & self-report
- citation Count
- 1
- citation Snapshot
- count
- 1
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/40621706
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/40621706/ · https://doi.org/10.1002/brb3.70671 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12230630/
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- evidence
- intervention
- Binaural auditory stimulation during stroke rehabilitation
- comparator
- Music during rehabilitation
- evidence Type
- Clinical or experimental outcomes
- source URLs
https://pubmed.ncbi.nlm.nih.gov/40621706/ · https://doi.org/10.1002/brb3.70671 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12230630/
- checked At
- 2026-10-26
- review Scope
- Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
- discovery Sources
https://daytab.com/study/bmtv2256 · https://europepmc.org/article/MED/40621706
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
- id
- sound-i-pmid-40621706
- record Id
- pmid-40621706
- quotes
- None recorded
- source Pages
- None recorded
- summary
- Among 27 stroke rehabilitation completers, the binaural-stimulation group improved daily-living and depression scores more than the music comparison group. Balance measures improved in both groups.
- limitation
- The small sample and combined rehabilitation context limit causal attribution to the beats. Correlations between functional measures do not prove a brain mechanism.
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/40621706/ · https://doi.org/10.1002/brb3.70671 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12230630/
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- publication Key
- doi:10.1002/brb3.70671
- collection
- sound
- chapter Number
- 1
- topic Id
- i
- topic Title
- Brain entrainment, pain, anxiety and heart-rate variability
- trust Score
- 3
- evidence
- intervention
- Binaural auditory stimulation during stroke rehabilitation
- comparator
- Music during rehabilitation
- evidence Type
- Clinical or experimental outcomes
- source URLs
https://pubmed.ncbi.nlm.nih.gov/40621706/ · https://doi.org/10.1002/brb3.70671 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12230630/
- checked At
- 2026-10-26
- review Scope
- Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
- discovery Sources
https://daytab.com/study/bmtv2256 · https://europepmc.org/article/MED/40621706
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- id
- depression
- evidence
- field
- curated primary-source summary
- text
- Among 27 stroke rehabilitation completers, the binaural-stimulation group improved daily-living and depression scores more than the music comparison group. Balance measures improved in both groups.
- matched Text
- depression
- conditions
depression
- topic Trust Scores
3
- full Text
- status
- not-indexed
- retrieval Available
- false