Stress and stress reactivity in posttraumatic stress disorder (PTSD) following eye movement desensitization (EMD): A randomized controlled trial.
Susanty E, Sijbrandij M, van der Mee DJ, Srisayekti W, Suparman Y, Huizink AC. · Journal of behavior therapy and experimental psychiatry · 2025 · Randomized controlled component trial
Original publication · Original publication
Recorded summary
Ninety-one adults with PTSD received eye-movement desensitization or memory retrieval alone. Both groups showed reduced stress reactivity; the study found no specific overall benefit of eye movements and inconsistent cortisol differences.
Recorded limitations
Saliva timing depended on participant adherence. This is the same registered component trial as the 2024 neurocognitive report, not an independent replication.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Randomized controlled component trial
- assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Publication identity and reported study design checked. Outcome blinding is not established in the material reviewed; no single- or double-blind RCT classification is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/40706348/ · https://doi.org/10.1016/j.jbtep.2025.102052
- reviewed At
- 2026-10-23
- trust Factor
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Publication identity and reported study design checked. Outcome blinding is not established in the material reviewed; no single- or double-blind RCT classification is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/40706348/ · https://doi.org/10.1016/j.jbtep.2025.102052
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- evidence Type
- Molecular biomarkers
- measured Genes
- None recorded
- relationship Note
- Saliva timing depended on participant adherence. This is the same registered component trial as the 2024 neurocognitive report, not an independent replication.
- trial Id
- ISRCTN55239132
Topics and recorded topic scores
- key
- vision:biomarkers
- title
- EMDR, cortisol and molecular biomarkers
- collection
- vision
- trust Score
- 1
Citation snapshot and identifiers
- id
- pmid-40706348
- doi
- 10.1016/j.jbtep.2025.102052
- pmid
- 40706348
- citation Snapshot
- count
- 1
- source
- Crossref
- retrieved At
- 2026-10-23
- citations By Collection
- vision
- 1
Complete approved library record
- id
- pmid-40706348
- publication Key
- doi:10.1016/j.jbtep.2025.102052
- aliases
- None recorded
- title
- Stress and stress reactivity in posttraumatic stress disorder (PTSD) following eye movement desensitization (EMD): A randomized controlled trial.
- journal
- Journal of behavior therapy and experimental psychiatry
- neurotransmitters
- None recorded
- year
- 2025
- authors
- Susanty E, Sijbrandij M, van der Mee DJ, Srisayekti W, Suparman Y, Huizink AC.
- design
- Randomized controlled component trial
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1016/j.jbtep.2025.102052
- pmid
- 40706348
- urls
https://pubmed.ncbi.nlm.nih.gov/40706348/ · https://doi.org/10.1016/j.jbtep.2025.102052
- collections
vision
- categories
Molecular biomarkers · Clinical & self-report
- targets
- None recorded
- priority
- 1
- quotes
- None recorded
- summary
- Ninety-one adults with PTSD received eye-movement desensitization or memory retrieval alone. Both groups showed reduced stress reactivity; the study found no specific overall benefit of eye movements and inconsistent cortisol differences.
- limitation
- Saliva timing depended on participant adherence. This is the same registered component trial as the 2024 neurocognitive report, not an independent replication.
- citation Count
- 1
- citation Snapshot
- count
- 1
- source
- Crossref
- retrieved At
- 2026-10-23
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Publication identity and reported study design checked. Outcome blinding is not established in the material reviewed; no single- or double-blind RCT classification is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/40706348/ · https://doi.org/10.1016/j.jbtep.2025.102052
- reviewed At
- 2026-10-23
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Publication identity and reported study design checked. Outcome blinding is not established in the material reviewed; no single- or double-blind RCT classification is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/40706348/ · https://doi.org/10.1016/j.jbtep.2025.102052
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- vision
- 1
- topics
- key
- vision:biomarkers
- title
- EMDR, cortisol and molecular biomarkers
- collection
- vision
- trust Score
- 1
- journal Key
- journalofbehaviortherapyandexperimentalpsychiatry
- journal Label
- Journal of behavior therapy and experimental psychiatry
- chapter Entries
- title
- Stress and stress reactivity in posttraumatic stress disorder (PTSD) following eye movement desensitization (EMD): A randomized controlled trial.
- journal
- Journal of behavior therapy and experimental psychiatry
- year
- 2025
- authors
- Susanty E, Sijbrandij M, van der Mee DJ, Srisayekti W, Suparman Y, Huizink AC.
- design
- Randomized controlled component trial
- urls
https://pubmed.ncbi.nlm.nih.gov/40706348/ · https://doi.org/10.1016/j.jbtep.2025.102052
- doi
- 10.1016/j.jbtep.2025.102052
- pmid
- 40706348
- targets
- None recorded
- categories
Molecular biomarkers · Clinical & self-report
- citation Count
- 1
- citation Snapshot
- count
- 1
- source
- Crossref
- retrieved At
- 2026-10-23
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Publication identity and reported study design checked. Outcome blinding is not established in the material reviewed; no single- or double-blind RCT classification is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/40706348/ · https://doi.org/10.1016/j.jbtep.2025.102052
- reviewed At
- 2026-10-23
- evidence
- evidence Type
- Molecular biomarkers
- measured Genes
- None recorded
- relationship Note
- Saliva timing depended on participant adherence. This is the same registered component trial as the 2024 neurocognitive report, not an independent replication.
- trial Id
- ISRCTN55239132
- record Id
- pmid-40706348
- quotes
- None recorded
- source Pages
- None recorded
- summary
- Ninety-one adults with PTSD received eye-movement desensitization or memory retrieval alone. Both groups showed reduced stress reactivity; the study found no specific overall benefit of eye movements and inconsistent cortisol differences.
- limitation
- Saliva timing depended on participant adherence. This is the same registered component trial as the 2024 neurocognitive report, not an independent replication.
- id
- vision-biomarkers-pmid-40706348
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Publication identity and reported study design checked. Outcome blinding is not established in the material reviewed; no single- or double-blind RCT classification is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/40706348/ · https://doi.org/10.1016/j.jbtep.2025.102052
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- publication Key
- doi:10.1016/j.jbtep.2025.102052
- collection
- vision
- chapter Number
- 4
- topic Id
- biomarkers
- topic Title
- EMDR, cortisol and molecular biomarkers
- trust Score
- 1
- evidence
- evidence Type
- Molecular biomarkers
- measured Genes
- None recorded
- relationship Note
- Saliva timing depended on participant adherence. This is the same registered component trial as the 2024 neurocognitive report, not an independent replication.
- trial Id
- ISRCTN55239132
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- id
- ptsd
- evidence
- field
- title
- text
- Stress and stress reactivity in posttraumatic stress disorder (PTSD) following eye movement desensitization (EMD): A randomized controlled trial.
- matched Text
- posttraumatic stress
- id
- trauma
- evidence
- field
- title
- text
- Stress and stress reactivity in posttraumatic stress disorder (PTSD) following eye movement desensitization (EMD): A randomized controlled trial.
- matched Text
- posttraumatic
- id
- stress
- evidence
- field
- title
- text
- Stress and stress reactivity in posttraumatic stress disorder (PTSD) following eye movement desensitization (EMD): A randomized controlled trial.
- matched Text
- Stress
- conditions
ptsd · trauma · stress
- topic Trust Scores
1
- full Text
- status
- not-indexed
- retrieval Available
- false