Irregular light schedules disrupt daily rhythms and dysregulate genes involved in neuroplasticity, motivation, and stress responses
Berbegal-Sáez P, Gallego-Landin I, Macía J, Valverde O. · Pharmacology, biochemistry, and behavior · 2025 · Controlled mouse light-schedule experiment
Original publication · Original publication
Recorded summary
Short-term changes to the light–dark schedule disrupted circadian rhythms and region-dependent expression of genes including Oxtr, Cry2 and Per2, despite limited behavioural changes.
Recorded limitations
Mouse light-schedule disruption is distinct from human screen use, EMDR or geometric stimulation. The abstract does not establish a single direction of Oxtr change across tissues and time points.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Controlled mouse light-schedule experiment
- assessment
- Not recorded
- trust Factor
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-applicable
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/40749778/ · https://doi.org/10.1016/j.pbb.2025.174075
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- Not recorded
Topics and recorded topic scores
None recordedCitation snapshot and identifiers
- id
- pmid-40749778
- doi
- 10.1016/j.pbb.2025.174075
- pmid
- 40749778
- citation Snapshot
- Not recorded
- citations By Collection
- vision
- Not recorded
Complete approved library record
- id
- pmid-40749778
- publication Key
- Not recorded
- aliases
- None recorded
- title
- Irregular light schedules disrupt daily rhythms and dysregulate genes involved in neuroplasticity, motivation, and stress responses
- journal
- Pharmacology, biochemistry, and behavior
- neurotransmitters
- None recorded
- year
- 2025
- authors
- Berbegal-Sáez P, Gallego-Landin I, Macía J, Valverde O.
- design
- Controlled mouse light-schedule experiment
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1016/j.pbb.2025.174075
- pmid
- 40749778
- urls
https://doi.org/10.1016/j.pbb.2025.174075 · https://pubmed.ncbi.nlm.nih.gov/40749778/
- collections
vision
- categories
Gene expression
- targets
OXTR
- priority
- 0
- quotes
- None recorded
- summary
- Short-term changes to the light–dark schedule disrupted circadian rhythms and region-dependent expression of genes including Oxtr, Cry2 and Per2, despite limited behavioural changes.
- limitation
- Mouse light-schedule disruption is distinct from human screen use, EMDR or geometric stimulation. The abstract does not establish a single direction of Oxtr change across tissues and time points.
- citation Count
- Not recorded
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-applicable
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/40749778/ · https://doi.org/10.1016/j.pbb.2025.174075
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- vision
- Not recorded
- topics
- None recorded
- journal Key
- pharmacologybiochemistryandbehavior
- journal Label
- Pharmacology, biochemistry, and behavior
- chapter Entries
- None recorded
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- id
- stress
- evidence
- field
- title
- text
- Irregular light schedules disrupt daily rhythms and dysregulate genes involved in neuroplasticity, motivation, and stress responses
- matched Text
- stress
- conditions
stress
- topic Trust Scores
- None recorded
- full Text
- status
- not-indexed
- retrieval Available
- false