Oxidative stress-induced proinflammatory secretion from retinal pigment epithelium disrupts NAD+ metabolism via CD38 on macrophages leading to immune microenvironment dysregulation
Lin R, Liang F, Hu C, Jiang L, Wan Z, Xu Z, Luo Y, Ma J, Wu Y, Cai W, Yu J. · Free radical biology & medicine · 2026 · Mouse retinal-injury and cell-culture experiments
Original publication · Original publication
Recorded summary
Oxidatively damaged retinal pigment epithelium altered macrophage transcription and NAD+ metabolism. CD38 upregulation and inhibitor experiments implicated a CD38/NAD+ pathway.
Recorded limitations
This is oxidative-injury pathway research. It does not establish a visual-exposure effect or a human treatment benefit.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Mouse retinal-injury and cell-culture experiments
- assessment
- Not recorded
- trust Factor
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-applicable
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/41308935/ · https://doi.org/10.1016/j.freeradbiomed.2025.11.041
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- Not recorded
Topics and recorded topic scores
None recordedCitation snapshot and identifiers
- id
- pmid-41308935
- doi
- 10.1016/j.freeradbiomed.2025.11.041
- pmid
- 41308935
- citation Snapshot
- Not recorded
- citations By Collection
- vision
- Not recorded
Complete approved library record
- id
- pmid-41308935
- publication Key
- Not recorded
- aliases
- None recorded
- title
- Oxidative stress-induced proinflammatory secretion from retinal pigment epithelium disrupts NAD+ metabolism via CD38 on macrophages leading to immune microenvironment dysregulation
- journal
- Free radical biology & medicine
- neurotransmitters
- None recorded
- year
- 2026
- authors
- Lin R, Liang F, Hu C, Jiang L, Wan Z, Xu Z, Luo Y, Ma J, Wu Y, Cai W, Yu J.
- design
- Mouse retinal-injury and cell-culture experiments
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1016/j.freeradbiomed.2025.11.041
- pmid
- 41308935
- urls
https://doi.org/10.1016/j.freeradbiomed.2025.11.041 · https://pubmed.ncbi.nlm.nih.gov/41308935/
- collections
vision
- categories
Gene expression · Molecular biomarkers
- targets
CD38 · NAD+
- priority
- 0
- quotes
- None recorded
- summary
- Oxidatively damaged retinal pigment epithelium altered macrophage transcription and NAD+ metabolism. CD38 upregulation and inhibitor experiments implicated a CD38/NAD+ pathway.
- limitation
- This is oxidative-injury pathway research. It does not establish a visual-exposure effect or a human treatment benefit.
- citation Count
- Not recorded
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-applicable
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/41308935/ · https://doi.org/10.1016/j.freeradbiomed.2025.11.041
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- vision
- Not recorded
- topics
- None recorded
- journal Key
- freeradicalbiologyandmedicine
- journal Label
- Free radical biology & medicine
- chapter Entries
- None recorded
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
- None recorded
- full Text
- status
- not-indexed
- retrieval Available
- false