Clinical and Cost-Effectiveness of Eye Movement Desensitisation and Reprocessing for Post-Traumatic Stress Disorder in Children and Adolescents: A Systematic Review and Meta-Analysis.
Sutton A, Carroll C, Simpson E, Forsyth J, Rayner A, Ren S, Franklin M, Wood E. · Clinical psychology & psychotherapy · 2025 · Systematic review / meta-analysis
Original publication · Original publication · Original publication · Original publication · Original publication
Recorded summary
Pooled PTSD symptom effects favoured EMDR over waiting/usual care (SMD 1.57, 95% credible interval 0.07–3.21). Two direct comparisons did not establish superiority over trauma-focused CBT. Economic evidence was sparse.
Recorded limitations
All clinical studies were judged moderate or high risk of bias; wide uncertainty and little long-term evidence. Reviews and their included trials are not independent corroborating samples.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
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- Not applicable or not established from inspected methods; no masking inferred
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https://pubmed.ncbi.nlm.nih.gov/41340540/ · https://doi.org/10.1002/cpp.70186 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12676259/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12676259/fullTextXML · https://api.crossref.org/works/10.1002%2Fcpp.70186
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https://pubmed.ncbi.nlm.nih.gov/41340540/ · https://doi.org/10.1002/cpp.70186 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12676259/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12676259/fullTextXML · https://api.crossref.org/works/10.1002%2Fcpp.70186
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- EMDR for pediatric PTSD versus inactive or active comparators; six database searches through September 2023.
- provider
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- comparator
- See design/intervention description; otherwise unknown
- sample
- Eight clinical RCTs, 794 participants, and one economic study.
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- Children and adolescents, with adolescents defined as 10–19; no isolated 16–24 estimate.
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CRD42023463360
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- Identifiers explicitly reported in article abstract; other registrations remain unverified
- relationship Note
- Supports access to established trauma-focused clinical options and an explicit evidence-gap agenda, not a guaranteed lab outcome. Component evidence does not establish efficacy of the combined Universal Mind lab model.
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- retrieved At
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Topics and recorded topic scores
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- notice Summary
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- Sutton A, Carroll C, Simpson E, Forsyth J, Rayner A, Ren S, Franklin M, Wood E.
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- summary
- Pooled PTSD symptom effects favoured EMDR over waiting/usual care (SMD 1.57, 95% credible interval 0.07–3.21). Two direct comparisons did not establish superiority over trauma-focused CBT. Economic evidence was sparse.
- limitation
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https://pubmed.ncbi.nlm.nih.gov/41340540/ · https://doi.org/10.1002/cpp.70186 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12676259/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12676259/fullTextXML · https://api.crossref.org/works/10.1002%2Fcpp.70186
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EMDR
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- pmid-41340540
- source Pages
- None recorded
- legacy Article Stars
- Not recorded
- legacy Rating Basis
- Not recorded
- stars
- 1
- rating Basis
- Publication identity and reported study design checked. Outcome blinding is not established in the material reviewed; no single- or double-blind RCT classification is assigned.
- archive Entries
- None recorded
- assessment Record
- id
- youth-pmid-41340540
- title
- Clinical and Cost-Effectiveness of Eye Movement Desensitisation and Reprocessing for Post-Traumatic Stress Disorder in Children and Adolescents: A Systematic Review and Meta-Analysis.
- authors
- Sutton A, Carroll C, Simpson E, Forsyth J, Rayner A, Ren S, Franklin M, Wood E.
- year
- 2025
- journal
- Clinical psychology & psychotherapy
- doi
- 10.1002/cpp.70186
- pmid
- 41340540
- pmcid
- PMC12676259
- trial Registries
CRD42023463360
- registry Scope
- Identifiers explicitly reported in article abstract; other registrations remain unverified
- collection
- youth-20261102
- topics
EMDR
- institutions
- None recorded
- institution Evidence
- None recorded
- publication Type
Meta-Analysis · Systematic Review · review-article · Journal Article
- study Family Id
- publication-41340540
- randomized Study Unit Id
- Not recorded
- existing Repository Matches
- id
- pmid-41340540
- matched By
PMID · DOI · normalized exact title
- collections
vision
- population
- age
- Children and adolescents, with adolescents defined as 10–19; no isolated 16–24 estimate.
- age Fit
- mixed-overlap
- sample
- Eight clinical RCTs, 794 participants, and one economic study.
- setting
- Not separately established; see population/intervention description
- community
- Not assigned
- intervention
- description And Dose
- EMDR for pediatric PTSD versus inactive or active comparators; six database searches through September 2023.
- provider
- Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
- comparator
- See design/intervention description; otherwise unknown
- design
- description
- systematic-review-meta-analysis
- category
- review
- randomization Methods Inspected
- false
- masking
- Not applicable or not established from inspected methods; no masking inferred
- double Blinding Verified
- false
- proposed Crosses
- 1
- approved Crosses
- Not recorded
- findings
- Pooled PTSD symptom effects favoured EMDR over waiting/usual care (SMD 1.57, 95% credible interval 0.07–3.21). Two direct comparisons did not establish superiority over trauma-focused CBT. Economic evidence was sparse.
- limitations
- All clinical studies were judged moderate or high risk of bias; wide uncertainty and little long-term evidence. Reviews and their included trials are not independent corroborating samples.
- harms And Attrition
- Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm
- lab Relevance
- relationship
- inspired-by
- implication
- Supports access to established trauma-focused clinical options and an explicit evidence-gap agenda, not a guaranteed lab outcome.
- transfer Limit
- Component evidence does not establish efficacy of the combined Universal Mind lab model.
- source Access
- scope
- selected-methods
- full Text Cached
- true
- methods Inspected
- true
- full Text Appraisal Claim
- false
- sources
- type
- primary bibliographic record
- url
- https://pubmed.ncbi.nlm.nih.gov/41340540/
- retrieved At
- 2026-11-02
- sha256
- cd7803585589cfc117916fcbe62f2b28fe78cac16dd1f02a307e40cb3b7bb256
- hash Scope
- normalized Europe PMC core metadata snapshot
- type
- publisher DOI
- url
- https://doi.org/10.1002/cpp.70186
- retrieved At
- 2026-11-02
- type
- PMC article
- url
- https://pmc.ncbi.nlm.nih.gov/articles/PMC12676259/
- retrieved At
- 2026-11-02
- access
- Full text cached
- type
- full-text-xml
- url
- https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12676259/fullTextXML
- retrieved At
- 2026-11-02T00:59:16.779322+00:00
- sha256
- c13d7556afb130591fd381dfb662dd9d0c094626204cf8e7f914acd713357017
- type
- DOI-metadata
- url
- https://api.crossref.org/works/10.1002%2Fcpp.70186
- retrieved At
- 2026-11-02T00:59:16.782357+00:00
- sha256
- 2099fdbfe57ac7e22aa480659efd7f60bc12688bb49558b2976f298b949b2292
- publication Status
- pmid
- 41340540
- checked At
- 2026-11-02T01:32:46.784011+00:00
- pub Types
Meta-Analysis · Systematic Review · review-article · Journal Article
- indexed Notices
- None recorded
- crossref Updates
- None recorded
- notice Records
- None recorded
- scope
- Europe PMC indexed publication types/linked notices, publisher JATS related articles and Crossref update-to metadata; absence is not a guarantee of no notice.
- notice Summary
- Indexed related notices are retained below; no retraction identified in this bounded metadata check. This is not an exhaustive guarantee.
- quality
- tier
- priority
- qualification
- Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
- formal Risk Of Bias Tool Applied
- false
- jadad Score
- Not recorded
- review Ready
- true
- hold Reason
- Not recorded
- duplicate Of
- Not recorded
- review
- status
- pending
- reviewer
- Not recorded
- approved At
- Not recorded
- decision Scope
- Ben reviews proposed content and release; full medical-paper reading is not required.
- provenance
- Discovered and appraised by AI; pending human content sign-off
- production Eligible
- false
- approved Retrieval Eligible
- false
- selected Corpus References
- None recorded
- reference Scope
- Explicit publisher reference identifiers; citation is not proof of inclusion in a meta-analysis.
- content Hash
- c5e8b5f0e7344b8f1e79d95dbd4f71c63f15f8f3ff8358b0a36160f4d1ad0dd5
- revision
- r1-c5e8b5f0e734
- collection
- vision
- chapter Number
- 8
- topic Id
- emdr-youth
- topic Title
- EMDR for youth
- trust Score
- 2
- evidence
- evidence Type
- Systematic review / meta-analysis
- intervention
- EMDR for pediatric PTSD versus inactive or active comparators; six database searches through September 2023.
- provider
- Not separately established; clinician/teacher/app details, if known, are retained in the intervention description
- comparator
- See design/intervention description; otherwise unknown
- sample
- Eight clinical RCTs, 794 participants, and one economic study.
- population
- age
- Children and adolescents, with adolescents defined as 10–19; no isolated 16–24 estimate.
- age Fit
- mixed-overlap
- sample
- Eight clinical RCTs, 794 participants, and one economic study.
- setting
- Not separately established; see population/intervention description
- community
- Not assigned
- measurement
- Specific outcomes are reported in the finding and retained appraisal.
- trial Id
- publication-41340540
- trial Registries
CRD42023463360
- registry Scope
- Identifiers explicitly reported in article abstract; other registrations remain unverified
- relationship Note
- Supports access to established trauma-focused clinical options and an explicit evidence-gap agenda, not a guaranteed lab outcome. Component evidence does not establish efficacy of the combined Universal Mind lab model.
- measured Genes
- None recorded
- pathways
- None recorded
- quality
- tier
- priority
- qualification
- Qualified for the stated design-specific use in a rapid methods-based review, not necessarily low risk of bias or high certainty.
- formal Risk Of Bias Tool Applied
- false
- jadad Score
- Not recorded
- masking Roles
- Not applicable or not established from inspected methods; no masking inferred
- harms And Attrition
- Not systematically extracted beyond findings/limitations; absence of reporting is not evidence of no harm
- source Access
- scope
- selected-methods
- full Text Cached
- true
- methods Inspected
- true
- full Text Appraisal Claim
- false
- level
- selected-methods
- source URLs
https://pubmed.ncbi.nlm.nih.gov/41340540/ · https://doi.org/10.1002/cpp.70186 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12676259/ · https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12676259/fullTextXML · https://api.crossref.org/works/10.1002%2Fcpp.70186
- retrieved At
- 2026-11-02
- jadad
- status
- not-applicable
- score
- Not recorded
- condition Evidence
- id
- ptsd
- evidence
- field
- title
- text
- Clinical and Cost-Effectiveness of Eye Movement Desensitisation and Reprocessing for Post-Traumatic Stress Disorder in Children and Adolescents: A Systematic Review and Meta-Analysis.
- matched Text
- Post-Traumatic Stress
- field
- findings
- text
- Pooled PTSD symptom effects favoured EMDR over waiting/usual care (SMD 1.57, 95% credible interval 0.07–3.21). Two direct comparisons did not establish superiority over trauma-focused CBT. Economic evidence was sparse.
- matched Text
- PTSD
- scope
- Studied topic or reported outcome, including null findings; no diagnosis, benefit or subgroup membership is inferred.
- id
- trauma
- evidence
- field
- title
- text
- Clinical and Cost-Effectiveness of Eye Movement Desensitisation and Reprocessing for Post-Traumatic Stress Disorder in Children and Adolescents: A Systematic Review and Meta-Analysis.
- matched Text
- Post-Traumatic
- field
- findings
- text
- Pooled PTSD symptom effects favoured EMDR over waiting/usual care (SMD 1.57, 95% credible interval 0.07–3.21). Two direct comparisons did not establish superiority over trauma-focused CBT. Economic evidence was sparse.
- matched Text
- trauma
- scope
- Studied topic or reported outcome, including null findings; no diagnosis, benefit or subgroup membership is inferred.
- conditions
ptsd · trauma
- topic Trust Scores
2
- full Text
- status
- open-license
- retrieval Available
- true
- url
- https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12676259/fullTextXML
- pmcid
- PMC12676259
- rights
- license
- https://creativecommons.org/licenses/by/4.0/
- statement
© 2025 The Author(s). Clinical Psychology & Psychotherapy published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- sha256
- c13d7556afb130591fd381dfb662dd9d0c094626204cf8e7f914acd713357017
- checked At
- 2026-10-24