Decoding the peripheral transcriptomic and meta-genomic response to music in autism spectrum disorder via saliva-based RNA sequencing
Cavenaghi A, Mallah NEZ, Navarro L, Martinón-Torres F, Gómez-Carballa A, Salas A. · Frontiers in Molecular Biosciences · 2025 · Exploratory human pilot
Original publication · Original publication · Original publication
Recorded summary
The pilot detected exploratory RNA and microbial changes after music exposure, including signals involving HERC6, TSPAN5 and REM2.
Recorded limitations
Five participants and exploratory integration of sequencing methods limit inference. This is not evidence of a clinical treatment effect.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Exploratory human pilot
- assessment
- Not recorded
- trust Factor
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/41367385/ · https://doi.org/10.3389/fmolb.2025.1696704
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- Not recorded
Topics and recorded topic scores
None recordedCitation snapshot and identifiers
- id
- pmid-41367385
- doi
- 10.3389/fmolb.2025.1696704
- pmid
- 41367385
- citation Snapshot
- Not recorded
- citations By Collection
- sound
- Not recorded
Complete approved library record
- id
- pmid-41367385
- publication Key
- Not recorded
- aliases
- None recorded
- title
- Decoding the peripheral transcriptomic and meta-genomic response to music in autism spectrum disorder via saliva-based RNA sequencing
- journal
- Frontiers in Molecular Biosciences
- publisher Family
- frontiers
- publisher Family Label
- Frontiers
- neurotransmitters
- None recorded
- year
- 2025
- authors
- Cavenaghi A, Mallah NEZ, Navarro L, Martinón-Torres F, Gómez-Carballa A, Salas A.
- design
- Exploratory human pilot
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.3389/fmolb.2025.1696704
- pmid
- 41367385
- urls
https://doi.org/10.3389/fmolb.2025.1696704 · https://pmc.ncbi.nlm.nih.gov/articles/PMC12682756/ · https://pubmed.ncbi.nlm.nih.gov/41367385/
- collections
sound
- categories
Gene expression
- targets
- None recorded
- priority
- 0
- quotes
- None recorded
- summary
- The pilot detected exploratory RNA and microbial changes after music exposure, including signals involving HERC6, TSPAN5 and REM2.
- limitation
- Five participants and exploratory integration of sequencing methods limit inference. This is not evidence of a clinical treatment effect.
- citation Count
- Not recorded
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/41367385/ · https://doi.org/10.3389/fmolb.2025.1696704
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- sound
- Not recorded
- topics
- None recorded
- journal Key
- frontiersinmolecularbiosciences
- journal Label
- Frontiers in Molecular Biosciences
- chapter Entries
- None recorded
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- id
- autism
- evidence
- field
- title
- text
- Decoding the peripheral transcriptomic and meta-genomic response to music in autism spectrum disorder via saliva-based RNA sequencing
- matched Text
- autism
- conditions
autism
- topic Trust Scores
- None recorded
- full Text
- status
- open-license
- retrieval Available
- true
- url
- https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12682756/fullTextXML
- pmcid
- PMC12682756
- rights
- license
- https://creativecommons.org/licenses/by/4.0/
- statement
Copyright © 2025 Cavenaghi, Mallah, Navarro, Martinón-Torres, Gómez-Carballa and Salas. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- sha256
- 1eff8daf8d50e7b8b828fe7cbcd62d9e8862d9acd9329b8571a78c6ef1b202cb
- checked At
- 2026-10-24