Community singing intervention reduces maternal salivary cytokines and enhances maternal-infant cortisol synchrony in postnatal depression: biological findings from the SHAPER-PND trial
Kirkpatrick M, Priestley K, Bind RH, Rebecchini L, Borsini A, Estevao C, Hazelgrove K, Laijawala R, Alford S, Woods AJ, Crane N, Manoharan M, Burton A, Dye H, Osborn T, Greenwood L, Dazzan P, Fancourt D, Pariante C. · Brain, behavior, and immunity · 2026 · Biomarker analysis within a randomized trial
Original publication · Original publication
Recorded summary
After the first community-singing session, salivary IL-6 decreased by 26% in the singing group. The time-by-group interaction for IL-6 was significant. Later analyses also examined mother–infant cortisol synchrony and communication.
Recorded limitations
This measured salivary cytokine protein, not IL6 transcription. The biological subset was unbalanced, and speech correlations do not isolate the causal effect of particular words.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Biomarker analysis within a randomized trial
- assessment
- Not recorded
- trust Factor
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Randomized controlled design recorded in the publication-specific design or bibliographic indexing.
- sources
https://pubmed.ncbi.nlm.nih.gov/41974356/ · https://doi.org/10.1016/j.bbi.2026.106600
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- Not recorded
Topics and recorded topic scores
None recordedCitation snapshot and identifiers
- id
- pmid-41974356
- doi
- 10.1016/j.bbi.2026.106600
- pmid
- 41974356
- citation Snapshot
- Not recorded
- citations By Collection
- sound
- Not recorded
- language
- Not recorded
Complete approved library record
- id
- pmid-41974356
- publication Key
- Not recorded
- aliases
- None recorded
- title
- Community singing intervention reduces maternal salivary cytokines and enhances maternal-infant cortisol synchrony in postnatal depression: biological findings from the SHAPER-PND trial
- journal
- Brain, behavior, and immunity
- neurotransmitters
- None recorded
- year
- 2026
- authors
- Kirkpatrick M, Priestley K, Bind RH, Rebecchini L, Borsini A, Estevao C, Hazelgrove K, Laijawala R, Alford S, Woods AJ, Crane N, Manoharan M, Burton A, Dye H, Osborn T, Greenwood L, Dazzan P, Fancourt D, Pariante C.
- design
- Biomarker analysis within a randomized trial
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1016/j.bbi.2026.106600
- pmid
- 41974356
- urls
https://doi.org/10.1016/j.bbi.2026.106600 · https://pubmed.ncbi.nlm.nih.gov/41974356/
- collections
sound · language
- categories
Molecular biomarkers · Clinical & self-report
- targets
IL6 · TNF
- priority
- 1
- quotes
- None recorded
- summary
- After the first community-singing session, salivary IL-6 decreased by 26% in the singing group. The time-by-group interaction for IL-6 was significant. Later analyses also examined mother–infant cortisol synchrony and communication.
- limitation
- This measured salivary cytokine protein, not IL6 transcription. The biological subset was unbalanced, and speech correlations do not isolate the causal effect of particular words.
- citation Count
- Not recorded
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Randomized controlled design recorded in the publication-specific design or bibliographic indexing.
- sources
https://pubmed.ncbi.nlm.nih.gov/41974356/ · https://doi.org/10.1016/j.bbi.2026.106600
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- sound
- Not recorded
- language
- Not recorded
- topics
- None recorded
- journal Key
- brainbehaviorandimmunity
- journal Label
- Brain, behavior, and immunity
- chapter Entries
- None recorded
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- id
- depression
- evidence
- field
- title
- text
- Community singing intervention reduces maternal salivary cytokines and enhances maternal-infant cortisol synchrony in postnatal depression: biological findings from the SHAPER-PND trial
- matched Text
- depression
- conditions
depression
- topic Trust Scores
- None recorded
- full Text
- status
- not-indexed
- retrieval Available
- false