Effects of binaural beats on acute stress recovery and autonomic regulation in multiple sclerosis: a pilot double-blind randomized controlled trial.
Vaheb S, Hatef B, Mirani A, Shaygannejad V, Pirzad Jahromi G. · Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026 · Double-blind randomized controlled pilot trial
Original publication · Original publication
Recorded summary
A pilot involving 30 people with multiple sclerosis and 30 healthy participants reported lower salivary cortisol after 4 Hz binaural stimulation than sham following an experimental stress challenge, alongside autonomic and EEG changes.
Recorded limitations
Small, mixed participant groups and acute follow-up limit generalisation. Cortisol is a hormonal biomarker; this study did not measure gene expression or demonstrate long-term clinical benefit.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Double-blind randomized controlled pilot trial
- assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/42307797/ · https://doi.org/10.1007/s10072-026-09164-4
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- trust Factor
- score
- 3
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- double
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/42307797/ · https://doi.org/10.1007/s10072-026-09164-4
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- intervention
- 4 Hz binaural beats after a stress challenge
- comparator
- Matched-frequency sham stimulation
- evidence Type
- Clinical or experimental outcomes
- source URLs
https://pubmed.ncbi.nlm.nih.gov/42307797/ · https://doi.org/10.1007/s10072-026-09164-4
- checked At
- 2026-10-26
- review Scope
- Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
- discovery Sources
https://daytab.com/study/27w34k8m · https://europepmc.org/article/MED/42307797
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
Topics and recorded topic scores
- key
- sound:i
- title
- Brain entrainment, pain, anxiety and heart-rate variability
- collection
- sound
- trust Score
- 3
Citation snapshot and identifiers
- id
- pmid-42307797
- doi
- 10.1007/s10072-026-09164-4
- pmid
- 42307797
- citation Snapshot
- count
- 0
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/42307797
- citations By Collection
- sound
- 0
Complete approved library record
- id
- pmid-42307797
- publication Key
- doi:10.1007/s10072-026-09164-4
- aliases
- None recorded
- title
- Effects of binaural beats on acute stress recovery and autonomic regulation in multiple sclerosis: a pilot double-blind randomized controlled trial.
- journal
- Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
- neurotransmitters
- None recorded
- year
- 2026
- authors
- Vaheb S, Hatef B, Mirani A, Shaygannejad V, Pirzad Jahromi G.
- design
- Double-blind randomized controlled pilot trial
- identity Conflict
- Not recorded
- doi
- 10.1007/s10072-026-09164-4
- pmid
- 42307797
- urls
https://pubmed.ncbi.nlm.nih.gov/42307797/ · https://doi.org/10.1007/s10072-026-09164-4
- collections
sound
- categories
Clinical & self-report · Molecular biomarkers
- targets
- None recorded
- priority
- 1
- quotes
- None recorded
- summary
- A pilot involving 30 people with multiple sclerosis and 30 healthy participants reported lower salivary cortisol after 4 Hz binaural stimulation than sham following an experimental stress challenge, alongside autonomic and EEG changes.
- limitation
- Small, mixed participant groups and acute follow-up limit generalisation. Cortisol is a hormonal biomarker; this study did not measure gene expression or demonstrate long-term clinical benefit.
- citation Count
- 0
- citation Snapshot
- count
- 0
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/42307797
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/42307797/ · https://doi.org/10.1007/s10072-026-09164-4
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- paper Trust Assessment
- score
- 3
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- double
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/42307797/ · https://doi.org/10.1007/s10072-026-09164-4
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- sound
- 0
- topics
- key
- sound:i
- title
- Brain entrainment, pain, anxiety and heart-rate variability
- collection
- sound
- trust Score
- 3
- journal Key
- neurologicalsciences
- journal Label
- Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
- chapter Entries
- title
- Effects of binaural beats on acute stress recovery and autonomic regulation in multiple sclerosis: a pilot double-blind randomized controlled trial.
- journal
- Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
- year
- 2026
- authors
- Vaheb S, Hatef B, Mirani A, Shaygannejad V, Pirzad Jahromi G.
- design
- Double-blind randomized controlled pilot trial
- urls
https://pubmed.ncbi.nlm.nih.gov/42307797/ · https://doi.org/10.1007/s10072-026-09164-4
- doi
- 10.1007/s10072-026-09164-4
- pmid
- 42307797
- targets
- None recorded
- categories
Clinical & self-report · Molecular biomarkers
- citation Count
- 0
- citation Snapshot
- count
- 0
- source
- Europe PMC
- retrieved At
- 2026-10-26
- url
- https://europepmc.org/article/MED/42307797
- study Design Assessment
- category
- peer-reviewed
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/42307797/ · https://doi.org/10.1007/s10072-026-09164-4
- assessed At
- 2026-10-26
- registered Masking Basis
- false
- evidence
- intervention
- 4 Hz binaural beats after a stress challenge
- comparator
- Matched-frequency sham stimulation
- evidence Type
- Clinical or experimental outcomes
- source URLs
https://pubmed.ncbi.nlm.nih.gov/42307797/ · https://doi.org/10.1007/s10072-026-09164-4
- checked At
- 2026-10-26
- review Scope
- Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
- discovery Sources
https://daytab.com/study/27w34k8m · https://europepmc.org/article/MED/42307797
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
- id
- sound-i-pmid-42307797
- record Id
- pmid-42307797
- quotes
- None recorded
- source Pages
- None recorded
- summary
- A pilot involving 30 people with multiple sclerosis and 30 healthy participants reported lower salivary cortisol after 4 Hz binaural stimulation than sham following an experimental stress challenge, alongside autonomic and EEG changes.
- limitation
- Small, mixed participant groups and acute follow-up limit generalisation. Cortisol is a hormonal biomarker; this study did not measure gene expression or demonstrate long-term clinical benefit.
- paper Trust Assessment
- score
- 3
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- double
- peer Reviewed
- true
- basis
- Reported design checked against the primary publication abstract. Blinding terminology reflects the source report, not an independent risk-of-bias rating.
- sources
https://pubmed.ncbi.nlm.nih.gov/42307797/ · https://doi.org/10.1007/s10072-026-09164-4
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- publication Key
- doi:10.1007/s10072-026-09164-4
- collection
- sound
- chapter Number
- 1
- topic Id
- i
- topic Title
- Brain entrainment, pain, anxiety and heart-rate variability
- trust Score
- 3
- evidence
- intervention
- 4 Hz binaural beats after a stress challenge
- comparator
- Matched-frequency sham stimulation
- evidence Type
- Clinical or experimental outcomes
- source URLs
https://pubmed.ncbi.nlm.nih.gov/42307797/ · https://doi.org/10.1007/s10072-026-09164-4
- checked At
- 2026-10-26
- review Scope
- Primary publication abstract and bibliographic identity checked; comprehensive full-text risk-of-bias and Jadad assessment pending.
- discovery Sources
https://daytab.com/study/27w34k8m · https://europepmc.org/article/MED/42307797
- selection Policy
- Success-focused discovery selection, with material limitations retained; not an exhaustive systematic review.
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- id
- stress
- evidence
- field
- curated primary-source summary
- text
- A pilot involving 30 people with multiple sclerosis and 30 healthy participants reported lower salivary cortisol after 4 Hz binaural stimulation than sham following an experimental stress challenge, alongside autonomic and EEG changes.
- matched Text
- stress
- conditions
stress
- topic Trust Scores
3
- full Text
- status
- not-indexed
- retrieval Available
- false