High-Color-Temperature Lighting Is Associated With Activation of MAPK/ERK-nNOS Signaling and MMP-2-Related Pathways in Ocular Tissues
Chiang YW, Chang JY, Yeh KL, Lin RY, Yeh SM. · Investigative ophthalmology & visual science · 2026 · Controlled mouse lighting experiment
Original publication · Original publication · Original publication
Recorded summary
After 21 days, higher-colour-temperature lighting was associated with increased nNOS, IL-6, TNF and other signalling proteins, without detectable axial-length or structural changes.
Recorded limitations
Protein abundance is not an RNA-expression measurement. The result concerns a defined mouse exposure and includes inflammatory responses rather than an established benefit.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Controlled mouse lighting experiment
- assessment
- Not recorded
- trust Factor
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-applicable
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/42339887/ · https://doi.org/10.1167/iovs.67.6.46
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- Not recorded
Topics and recorded topic scores
None recordedCitation snapshot and identifiers
- id
- pmid-42339887
- doi
- 10.1167/iovs.67.6.46
- pmid
- 42339887
- citation Snapshot
- Not recorded
- citations By Collection
- vision
- Not recorded
Complete approved library record
- id
- pmid-42339887
- publication Key
- Not recorded
- aliases
- None recorded
- title
- High-Color-Temperature Lighting Is Associated With Activation of MAPK/ERK-nNOS Signaling and MMP-2-Related Pathways in Ocular Tissues
- journal
- Investigative ophthalmology & visual science
- neurotransmitters
- None recorded
- year
- 2026
- authors
- Chiang YW, Chang JY, Yeh KL, Lin RY, Yeh SM.
- design
- Controlled mouse lighting experiment
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1167/iovs.67.6.46
- pmid
- 42339887
- urls
https://pmc.ncbi.nlm.nih.gov/articles/PMC13313043/ · https://pubmed.ncbi.nlm.nih.gov/42339887/ · https://doi.org/10.1167/iovs.67.6.46
- collections
vision
- categories
Molecular biomarkers
- targets
NOS1 · IL6 · TNF
- priority
- 1
- quotes
- None recorded
- summary
- After 21 days, higher-colour-temperature lighting was associated with increased nNOS, IL-6, TNF and other signalling proteins, without detectable axial-length or structural changes.
- limitation
- Protein abundance is not an RNA-expression measurement. The result concerns a defined mouse exposure and includes inflammatory responses rather than an established benefit.
- citation Count
- Not recorded
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- false
- blinding
- not-applicable
- peer Reviewed
- true
- basis
- Indexed peer-reviewed research; a qualifying randomized controlled design is not established in the reviewed record.
- sources
https://pubmed.ncbi.nlm.nih.gov/42339887/ · https://doi.org/10.1167/iovs.67.6.46
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- vision
- Not recorded
- topics
- None recorded
- journal Key
- investigativeophthalmologyandvisualscience
- journal Label
- Investigative ophthalmology & visual science
- chapter Entries
- None recorded
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
- None recorded
- full Text
- status
- open-license
- retrieval Available
- true
- url
- https://www.ebi.ac.uk/europepmc/webservices/rest/PMC13313043/fullTextXML
- pmcid
- PMC13313043
- rights
- license
- CC BY (version not specified in article)
- statement
Copyright 2026 The Authors This work is licensed under a Creative Commons Attribution 4.0 International License.
- sha256
- 1518f2652ac17b6afcccad429f6dc89f3b46bef8e72956c20c4123aec7fd25ac
- checked At
- 2026-10-24