MicroRNAs expression changes associated with trauma-focused psychotherapy efficacy in treatment-resistant depression: An exploratory study.
Buson L, Carvalho Silva R, Galbiati C, Bortolomasi M, Scaglia M, Perusi G, Abate M, Maffioletti E, Gennarelli M, Lorenzon N, Dierssen M, European College of Neuropsychopharmacology (ECNP) Pharmacogenomics & Transcriptomics Network, Minelli A. · Neuroscience applied · 2026 · Exploratory longitudinal microRNA study
Original publication · Original publication · Original publication
Recorded summary
In 24 people receiving EMDR or trauma-focused CBT for treatment-resistant depression, 148 microRNAs passed quality control. The combined sample’s miR-132-3p change survived correction for multiple testing.
Recorded limitations
EMDR-only subgroup changes did not survive multiple-testing correction. The result does not establish an EMDR-specific microRNA effect.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Exploratory longitudinal microRNA study
- assessment
- category
- observational
- peer Reviewed
- true
- basis
- Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/42519422/ · https://doi.org/10.1016/j.nsa.2026.107020
- reviewed At
- 2026-10-23
- trust Factor
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/42519422/ · https://doi.org/10.1016/j.nsa.2026.107020
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- evidence Type
- Genomics & gene expression
- measured Genes
MIR132
- relationship Note
- EMDR-only subgroup changes did not survive multiple-testing correction. The result does not establish an EMDR-specific microRNA effect.
Topics and recorded topic scores
- key
- vision:rna
- title
- EMDR and trauma-focused psychotherapy: gene expression
- collection
- vision
- trust Score
- Not recorded
Citation snapshot and identifiers
- id
- pmid-42519422
- doi
- 10.1016/j.nsa.2026.107020
- pmid
- 42519422
- citation Snapshot
- count
- 0
- source
- Crossref
- retrieved At
- 2026-10-23
- citations By Collection
- vision
- 0
- language
- Not recorded
Complete approved library record
- id
- pmid-42519422
- publication Key
- doi:10.1016/j.nsa.2026.107020
- aliases
- None recorded
- title
- MicroRNAs expression changes associated with trauma-focused psychotherapy efficacy in treatment-resistant depression: An exploratory study.
- journal
- Neuroscience applied
- neurotransmitters
- None recorded
- year
- 2026
- authors
- Buson L, Carvalho Silva R, Galbiati C, Bortolomasi M, Scaglia M, Perusi G, Abate M, Maffioletti E, Gennarelli M, Lorenzon N, Dierssen M, European College of Neuropsychopharmacology (ECNP) Pharmacogenomics & Transcriptomics Network, Minelli A.
- design
- Exploratory longitudinal microRNA study
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.1016/j.nsa.2026.107020
- pmid
- 42519422
- urls
https://pmc.ncbi.nlm.nih.gov/articles/PMC13383946/ · https://pubmed.ncbi.nlm.nih.gov/42519422/ · https://doi.org/10.1016/j.nsa.2026.107020
- collections
vision · language
- categories
Genomics & gene expression · Clinical & self-report
- targets
MIR132
- priority
- 0
- quotes
- None recorded
- summary
- In 24 people receiving EMDR or trauma-focused CBT for treatment-resistant depression, 148 microRNAs passed quality control. The combined sample’s miR-132-3p change survived correction for multiple testing.
- limitation
- EMDR-only subgroup changes did not survive multiple-testing correction. The result does not establish an EMDR-specific microRNA effect.
- citation Count
- 0
- citation Snapshot
- count
- 0
- source
- Crossref
- retrieved At
- 2026-10-23
- study Design Assessment
- category
- observational
- peer Reviewed
- true
- basis
- Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/42519422/ · https://doi.org/10.1016/j.nsa.2026.107020
- reviewed At
- 2026-10-23
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/42519422/ · https://doi.org/10.1016/j.nsa.2026.107020
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- vision
- 0
- language
- Not recorded
- topics
- key
- vision:rna
- title
- EMDR and trauma-focused psychotherapy: gene expression
- collection
- vision
- trust Score
- Not recorded
- journal Key
- neuroscienceapplied
- journal Label
- Neuroscience applied
- chapter Entries
- title
- MicroRNAs expression changes associated with trauma-focused psychotherapy efficacy in treatment-resistant depression: An exploratory study.
- journal
- Neuroscience applied
- year
- 2026
- authors
- Buson L, Carvalho Silva R, Galbiati C, Bortolomasi M, Scaglia M, Perusi G, Abate M, Maffioletti E, Gennarelli M, Lorenzon N, Dierssen M, European College of Neuropsychopharmacology (ECNP) Pharmacogenomics & Transcriptomics Network, Minelli A.
- design
- Exploratory longitudinal microRNA study
- urls
https://pmc.ncbi.nlm.nih.gov/articles/PMC13383946/ · https://pubmed.ncbi.nlm.nih.gov/42519422/ · https://doi.org/10.1016/j.nsa.2026.107020
- doi
- 10.1016/j.nsa.2026.107020
- pmid
- 42519422
- targets
MIR132
- categories
Genomics & gene expression · Clinical & self-report
- citation Count
- 0
- citation Snapshot
- count
- 0
- source
- Crossref
- retrieved At
- 2026-10-23
- study Design Assessment
- category
- observational
- peer Reviewed
- true
- basis
- Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/42519422/ · https://doi.org/10.1016/j.nsa.2026.107020
- reviewed At
- 2026-10-23
- evidence
- evidence Type
- Genomics & gene expression
- measured Genes
MIR132
- relationship Note
- EMDR-only subgroup changes did not survive multiple-testing correction. The result does not establish an EMDR-specific microRNA effect.
- record Id
- pmid-42519422
- quotes
- None recorded
- source Pages
- None recorded
- summary
- In 24 people receiving EMDR or trauma-focused CBT for treatment-resistant depression, 148 microRNAs passed quality control. The combined sample’s miR-132-3p change survived correction for multiple testing.
- limitation
- EMDR-only subgroup changes did not survive multiple-testing correction. The result does not establish an EMDR-specific microRNA effect.
- id
- vision-rna-pmid-42519422
- paper Trust Assessment
- score
- 1
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- Not recorded
- blinding
- not-confirmed
- peer Reviewed
- true
- basis
- Molecular or biomarker analysis with combined trauma-focused treatment exposure. No independently verified single- or double-blind randomized molecular comparison is assigned.
- sources
https://pubmed.ncbi.nlm.nih.gov/42519422/ · https://doi.org/10.1016/j.nsa.2026.107020
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- publication Key
- doi:10.1016/j.nsa.2026.107020
- collection
- vision
- chapter Number
- 4
- topic Id
- rna
- topic Title
- EMDR and trauma-focused psychotherapy: gene expression
- trust Score
- Not recorded
- evidence
- evidence Type
- Genomics & gene expression
- measured Genes
MIR132
- relationship Note
- EMDR-only subgroup changes did not survive multiple-testing correction. The result does not establish an EMDR-specific microRNA effect.
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- id
- trauma
- evidence
- field
- title
- text
- MicroRNAs expression changes associated with trauma-focused psychotherapy efficacy in treatment-resistant depression: An exploratory study.
- matched Text
- trauma
- id
- depression
- evidence
- field
- title
- text
- MicroRNAs expression changes associated with trauma-focused psychotherapy efficacy in treatment-resistant depression: An exploratory study.
- matched Text
- depression
- conditions
trauma · depression
- topic Trust Scores
- None recorded
- full Text
- status
- not-indexed
- retrieval Available
- false