Effects of a Standardized Music Intervention on Propofol Requirements and Serum Interleukin-6 and Prolactin in Deeply Sedated Mechanically Ventilated Adults: A Prespecified Secondary Analysis of a Randomized Clinical Trial
Fernández-Álvarez C, Mosteiro-Díaz MP, Zuazua-Rico D, Maestro-González A. · Healthcare (Basel, Switzerland) · 2026 · Open-label randomized trial; secondary analysis
Original publication · Original publication
Recorded summary
The trial found no significant adjusted between-group difference in serum IL-6 or prolactin. Propofol requirements decreased more in the music group among patients receiving that drug.
Recorded limitations
The parent trial was powered for a different primary outcome. An IL-6 protein measurement is separate from IL6 gene expression.
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- Open-label randomized trial; secondary analysis
- assessment
- Not recorded
- trust Factor
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- open-label
- peer Reviewed
- true
- basis
- Randomized controlled design recorded in the publication-specific design or bibliographic indexing.
- sources
https://pubmed.ncbi.nlm.nih.gov/42881739/ · https://doi.org/10.3390/healthcare14193300
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- Not recorded
Topics and recorded topic scores
None recordedCitation snapshot and identifiers
- id
- pmid-42881739
- doi
- 10.3390/healthcare14193300
- pmid
- 42881739
- citation Snapshot
- Not recorded
- citations By Collection
- sound
- Not recorded
Complete approved library record
- id
- pmid-42881739
- publication Key
- Not recorded
- aliases
- None recorded
- title
- Effects of a Standardized Music Intervention on Propofol Requirements and Serum Interleukin-6 and Prolactin in Deeply Sedated Mechanically Ventilated Adults: A Prespecified Secondary Analysis of a Randomized Clinical Trial
- journal
- Healthcare (Basel, Switzerland)
- neurotransmitters
- None recorded
- year
- 2026
- authors
- Fernández-Álvarez C, Mosteiro-Díaz MP, Zuazua-Rico D, Maestro-González A.
- design
- Open-label randomized trial; secondary analysis
- kind
- Journal article
- identity Conflict
- Not recorded
- doi
- 10.3390/healthcare14193300
- pmid
- 42881739
- urls
https://pubmed.ncbi.nlm.nih.gov/42881739/ · https://doi.org/10.3390/healthcare14193300
- collections
sound
- categories
Molecular biomarkers
- targets
IL6
- priority
- 1
- quotes
- None recorded
- summary
- The trial found no significant adjusted between-group difference in serum IL-6 or prolactin. Propofol requirements decreased more in the music group among patients receiving that drug.
- limitation
- The parent trial was powered for a different primary outcome. An IL-6 protein measurement is separate from IL6 gene expression.
- citation Count
- Not recorded
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- open-label
- peer Reviewed
- true
- basis
- Randomized controlled design recorded in the publication-specific design or bibliographic indexing.
- sources
https://pubmed.ncbi.nlm.nih.gov/42881739/ · https://doi.org/10.3390/healthcare14193300
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- sound
- Not recorded
- topics
- None recorded
- journal Key
- healthcare
- journal Label
- Healthcare (Basel, Switzerland)
- chapter Entries
- None recorded
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
- None recorded
- full Text
- status
- open-license
- retrieval Available
- true
- url
- https://www.ebi.ac.uk/europepmc/webservices/rest/PMC13664754/fullTextXML
- pmcid
- PMC13664754
- rights
- license
- https://creativecommons.org/licenses/by/4.0/
- statement
© 2026 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license .
- sha256
- 645631db28aa211bddd025eb35f2cedc37b903ef618c3baaf6ad74c59cd6816f
- checked At
- 2026-10-24