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Theta-Burst Transcranial Magnetic Stimulation for Posttraumatic Stress Disorder

The American Journal of Psychiatry · 2019 · Double-blind randomized sham-controlled phase, followed by an open extension

Original publication · Original publication · Original publication

Attributed extracts from the research record

“ Fifty veterans with PTSD received 10 days of sham-controlled iTBS (1,800 pulses/day), followed by 10 unblinded sessions.”
“ iTBS appears to be a promising new treatment for PTSD .”

Evidence and provenance

Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.

Study design and assessment
design
Double-blind randomized sham-controlled phase, followed by an open extension
assessment
category
double-blind-rct
peer Reviewed
true
basis
The initial two-week phase used randomized double-blind sham control. The later ten-session extension was unblinded; double blinding applies to the randomized phase.
sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC6824981/ · https://pubmed.ncbi.nlm.nih.gov/31230462/

assessed At
2026-10-27
review Scope
Primary abstract or specified methods and trial register; comprehensive full-text risk-of-bias assessment not completed.
trust Factor
score
3
scope
Paper
status
assessed
randomized Controlled Trial
true
blinding
double
peer Reviewed
true
basis
The initial two-week phase used randomized double-blind sham control. The later ten-session extension was unblinded; double blinding applies to the randomized phase.
sources

https://pubmed.ncbi.nlm.nih.gov/31230462/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC6824981/

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
jadad
status
unassessed
score
Not recorded
evidence
trial Id
NCT02769312
Topics and recorded topic scores
  1. key
    sound:iii
    title
    7.83 Hz and low-frequency electromagnetic research
    collection
    sound
    trust Score
    2
  2. key
    sound:xx
    title
    Brain entrainment, pain, anxiety and heart-rate variability in at-risk communities
    collection
    sound
    trust Score
    Not recorded
  3. key
    general:sound-iii
    title
    7.83 Hz and low-frequency electromagnetic research
    collection
    general
    trust Score
    2
Citation snapshot and identifiers
id
src-8ad1130190f0
doi
10.1176/appi.ajp.2019.18101160
pmid
31230462
citation Snapshot
Not recorded
citations By Collection
sound
Not recorded
general
Not recorded
Complete approved library record
id
src-8ad1130190f0
publication Key
Not recorded
aliases
None recorded
title
Theta-Burst Transcranial Magnetic Stimulation for Posttraumatic Stress Disorder
journal
The American Journal of Psychiatry
neurotransmitters
None recorded
year
2019
authors
design
Double-blind randomized sham-controlled phase, followed by an open extension
kind
Source record
identity Conflict
Not recorded
doi
10.1176/appi.ajp.2019.18101160
pmid
31230462
urls

https://pubmed.ncbi.nlm.nih.gov/31230462/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC6824981/ · https://doi.org/10.1176/appi.ajp.2019.18101160

collections

sound · general

categories

Clinical & self-report

targets
None recorded
priority
1
quotes

“ Fifty veterans with PTSD received 10 days of sham-controlled iTBS (1,800 pulses/day), followed by 10 unblinded sessions.” · “ iTBS appears to be a promising new treatment for PTSD .”

summary
limitation
citation Count
Not recorded
study Design Assessment
category
double-blind-rct
peer Reviewed
true
basis
The initial two-week phase used randomized double-blind sham control. The later ten-session extension was unblinded; double blinding applies to the randomized phase.
sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC6824981/ · https://pubmed.ncbi.nlm.nih.gov/31230462/

assessed At
2026-10-27
review Scope
Primary abstract or specified methods and trial register; comprehensive full-text risk-of-bias assessment not completed.
paper Trust Assessment
score
3
scope
Paper
status
assessed
randomized Controlled Trial
true
blinding
double
peer Reviewed
true
basis
The initial two-week phase used randomized double-blind sham control. The later ten-session extension was unblinded; double blinding applies to the randomized phase.
sources

https://pubmed.ncbi.nlm.nih.gov/31230462/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC6824981/

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
citations By Collection
sound
Not recorded
general
Not recorded
topics
  1. key
    sound:iii
    title
    7.83 Hz and low-frequency electromagnetic research
    collection
    sound
    trust Score
    2
  2. key
    sound:xx
    title
    Brain entrainment, pain, anxiety and heart-rate variability in at-risk communities
    collection
    sound
    trust Score
    Not recorded
  3. key
    general:sound-iii
    title
    7.83 Hz and low-frequency electromagnetic research
    collection
    general
    trust Score
    2
journal Key
americanjournalofpsychiatry
journal Label
The American Journal of Psychiatry
chapter Entries
  1. id
    iii-src-8ad1130190f0
    record Id
    src-8ad1130190f0
    title
    Theta-Burst Transcranial Magnetic Stimulation for Posttraumatic Stress Disorder
    journal
    The American Journal of Psychiatry
    year
    2019
    authors
    design
    Double-blind randomized sham-controlled phase, followed by an open extension
    urls

    https://pubmed.ncbi.nlm.nih.gov/31230462/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC6824981/ · https://doi.org/10.1176/appi.ajp.2019.18101160

    quotes
      1. text
        “
        emphasis
        false
      2. text
        Fifty veterans with PTSD
        emphasis
        true
      3. text
        received 10 days of sham-controlled iTBS (1,800 pulses/day), followed by 10 unblinded sessions.”
        emphasis
        false
      1. text
        “
        emphasis
        false
      2. text
        iTBS appears to be a promising new treatment for PTSD
        emphasis
        true
      3. text
        .”
        emphasis
        false
      1. text
        “intermittent
        emphasis
        false
      2. text
        theta
        emphasis
        true
      3. text
        burst
        emphasis
        false
      4. text
        stimulation
        emphasis
        true
      5. text
        fires a frequency of 50hz at 5 cycles per minute,
        emphasis
        false
      6. text
        5hz
        emphasis
        true
      7. text
        , for a therapeutic duration of 3 minutes”
        emphasis
        false
    citation Count
    Not recorded
    source Pages

    21

    targets
    None recorded
    categories

    Clinical & self-report

    doi
    10.1176/appi.ajp.2019.18101160
    pmid
    31230462
    quotation Review
    index
    2
    text
    The frequency sentence in the source PDF contains a unit error: 5 Hz is five cycles per second. It is retained below for review, separately from the article excerpts.
    url
    https://www.nature.com/articles/s41386-019-0584-4
    paper Trust Assessment
    score
    3
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    true
    blinding
    double
    peer Reviewed
    true
    basis
    The initial two-week phase used randomized double-blind sham control. The later ten-session extension was unblinded; double blinding applies to the randomized phase.
    sources

    https://pubmed.ncbi.nlm.nih.gov/31230462/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC6824981/

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    study Design Assessment
    category
    double-blind-rct
    peer Reviewed
    true
    basis
    The initial two-week phase used randomized double-blind sham control. The later ten-session extension was unblinded; double blinding applies to the randomized phase.
    sources

    https://pmc.ncbi.nlm.nih.gov/articles/PMC6824981/ · https://pubmed.ncbi.nlm.nih.gov/31230462/

    assessed At
    2026-10-27
    review Scope
    Primary abstract or specified methods and trial register; comprehensive full-text risk-of-bias assessment not completed.
    evidence
    trial Id
    NCT02769312
    identity Conflict
    Not recorded
    publication Status
    Primary publication identity resolved
    collection
    sound
    chapter Number
    1
    topic Id
    iii
    topic Title
    7.83 Hz and low-frequency electromagnetic research
    trust Score
    2
  2. id
    xx-src-8ad1130190f0
    record Id
    src-8ad1130190f0
    title
    Theta-Burst Transcranial Magnetic Stimulation for Posttraumatic Stress Disorder
    journal
    The American Journal of Psychiatry
    year
    2019
    authors
    design
    Double-blind randomized sham-controlled phase, followed by an open extension
    urls

    https://pubmed.ncbi.nlm.nih.gov/31230462/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC6824981/ · https://doi.org/10.1176/appi.ajp.2019.18101160

    quotes
      1. text
        “
        emphasis
        false
      2. text
        Fifty veterans with PTSD
        emphasis
        true
      3. text
        received 10 days of sham-controlled iTBS (1,800 pulses/day), followed by 10 unblinded sessions.”
        emphasis
        false
      1. text
        “
        emphasis
        false
      2. text
        iTBS appears to be a promising new treatment for PTSD
        emphasis
        true
      3. text
        .”
        emphasis
        false
      1. text
        “intermittent
        emphasis
        false
      2. text
        theta
        emphasis
        true
      3. text
        burst
        emphasis
        false
      4. text
        stimulation
        emphasis
        true
      5. text
        fires a frequency of 50hz at 5 cycles per minute,
        emphasis
        false
      6. text
        5hz
        emphasis
        true
      7. text
        , for a therapeutic duration of 3 minutes”
        emphasis
        false
    citation Count
    Not recorded
    source Pages

    91

    targets
    None recorded
    categories

    Clinical & self-report

    doi
    10.1176/appi.ajp.2019.18101160
    pmid
    31230462
    quotation Review
    index
    2
    text
    The frequency sentence in the source PDF contains a unit error: 5 Hz is five cycles per second. It is retained below for review, separately from the article excerpts.
    url
    https://www.nature.com/articles/s41386-019-0584-4
    paper Trust Assessment
    score
    3
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    true
    blinding
    double
    peer Reviewed
    true
    basis
    The initial two-week phase used randomized double-blind sham control. The later ten-session extension was unblinded; double blinding applies to the randomized phase.
    sources

    https://pubmed.ncbi.nlm.nih.gov/31230462/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC6824981/

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    study Design Assessment
    category
    double-blind-rct
    peer Reviewed
    true
    basis
    The initial two-week phase used randomized double-blind sham control. The later ten-session extension was unblinded; double blinding applies to the randomized phase.
    sources

    https://pmc.ncbi.nlm.nih.gov/articles/PMC6824981/ · https://pubmed.ncbi.nlm.nih.gov/31230462/

    assessed At
    2026-10-27
    review Scope
    Primary abstract or specified methods and trial register; comprehensive full-text risk-of-bias assessment not completed.
    evidence
    trial Id
    NCT02769312
    identity Conflict
    Not recorded
    publication Status
    Primary publication identity resolved
    collection
    sound
    chapter Number
    5
    topic Id
    xx
    topic Title
    Brain entrainment, pain, anxiety and heart-rate variability in at-risk communities
    trust Score
    Not recorded
  3. id
    general-iii-src-8ad1130190f0
    record Id
    src-8ad1130190f0
    title
    Theta-Burst Transcranial Magnetic Stimulation for Posttraumatic Stress Disorder
    journal
    The American Journal of Psychiatry
    year
    2019
    authors
    design
    Double-blind randomized sham-controlled phase, followed by an open extension
    urls

    https://pubmed.ncbi.nlm.nih.gov/31230462/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC6824981/ · https://doi.org/10.1176/appi.ajp.2019.18101160

    quotes
      1. text
        “
        emphasis
        false
      2. text
        Fifty veterans with PTSD
        emphasis
        true
      3. text
        received 10 days of sham-controlled iTBS (1,800 pulses/day), followed by 10 unblinded sessions.”
        emphasis
        false
      1. text
        “
        emphasis
        false
      2. text
        iTBS appears to be a promising new treatment for PTSD
        emphasis
        true
      3. text
        .”
        emphasis
        false
      1. text
        “intermittent
        emphasis
        false
      2. text
        theta
        emphasis
        true
      3. text
        burst
        emphasis
        false
      4. text
        stimulation
        emphasis
        true
      5. text
        fires a frequency of 50hz at 5 cycles per minute,
        emphasis
        false
      6. text
        5hz
        emphasis
        true
      7. text
        , for a therapeutic duration of 3 minutes”
        emphasis
        false
    citation Count
    Not recorded
    source Pages

    21

    targets
    None recorded
    categories

    Clinical & self-report

    doi
    10.1176/appi.ajp.2019.18101160
    pmid
    31230462
    quotation Review
    index
    2
    text
    The frequency sentence in the source PDF contains a unit error: 5 Hz is five cycles per second. It is retained below for review, separately from the article excerpts.
    url
    https://www.nature.com/articles/s41386-019-0584-4
    paper Trust Assessment
    score
    3
    scope
    Paper
    status
    assessed
    randomized Controlled Trial
    true
    blinding
    double
    peer Reviewed
    true
    basis
    The initial two-week phase used randomized double-blind sham control. The later ten-session extension was unblinded; double blinding applies to the randomized phase.
    sources

    https://pubmed.ncbi.nlm.nih.gov/31230462/ · https://pmc.ncbi.nlm.nih.gov/articles/PMC6824981/

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    study Design Assessment
    category
    double-blind-rct
    peer Reviewed
    true
    basis
    The initial two-week phase used randomized double-blind sham control. The later ten-session extension was unblinded; double blinding applies to the randomized phase.
    sources

    https://pmc.ncbi.nlm.nih.gov/articles/PMC6824981/ · https://pubmed.ncbi.nlm.nih.gov/31230462/

    assessed At
    2026-10-27
    review Scope
    Primary abstract or specified methods and trial register; comprehensive full-text risk-of-bias assessment not completed.
    evidence
    trial Id
    NCT02769312
    identity Conflict
    Not recorded
    publication Status
    Primary publication identity resolved
    collection
    general
    chapter Number
    2
    topic Id
    sound-iii
    topic Title
    7.83 Hz and low-frequency electromagnetic research
    trust Score
    2
evidence
trial Id
NCT02769312
jadad
status
unassessed
score
Not recorded
condition Evidence
  1. id
    ptsd
    evidence
    1. field
      title
      text
      Theta-Burst Transcranial Magnetic Stimulation for Posttraumatic Stress Disorder
      matched Text
      Posttraumatic Stress
  2. id
    trauma
    evidence
    1. field
      title
      text
      Theta-Burst Transcranial Magnetic Stimulation for Posttraumatic Stress Disorder
      matched Text
      Posttraumatic
  3. id
    stress
    evidence
    1. field
      title
      text
      Theta-Burst Transcranial Magnetic Stimulation for Posttraumatic Stress Disorder
      matched Text
      Stress
conditions

ptsd · trauma · stress

topic Trust Scores

2

full Text
status
reuse-review
retrieval Available
false
url
https://pmc-oa-opendata.s3.amazonaws.com/PMC6824981.1/PMC6824981.1.xml?md5=74292a10a08928f8ebc0cbe8496c2ca3
pmcid
PMC6824981
rights
license
TDM
use
Private text mining
public Fulltext Redistribution
false
provider Upload
false
model Training
false
basis
https://pmc.ncbi.nlm.nih.gov/tools/pmcaws/
article Rights

This file is available for text mining. It may also be used consistent with the principles of fair use under the copyright law.

sha256
45ac42f6d929fadda3f9f3a41ab4ef2fb92d60f27d52ccc152a97364d6a54d76
checked At
2026-10-24

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