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Striatal dopamine release after prefrontal repetitive transcranial magnetic stimulation in major depression: Preliminary results of a dynamic [123I] IBZM SPECT study

Journal of Psychiatric Research

Original publication

Attributed extracts from the research record

“Five patients with a major depressive episode (DSM-IV) underwent an acute 10 Hz rTMS challenge with 3000 stimuli over the left dorsolateral prefrontal cortex during an IBZM-SPECT bolus and constant infusion protocol.
Data of nine SPECT investigations showed a significant reduction by 9.6 ± 6.2% in IBZM binding to striatal dopamine D2 receptors after rTMS challenge compared to baseline.
The reduction of IBZM binding observed after rTMS challenge is suggestive of a release in endogenous dopamine induced by prefrontal rTMS.”
“dopamine modulates addiction”

Evidence and provenance

Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.

Study design and assessment
design
assessment
Not recorded
trust Factor
score
Not recorded
scope
Paper
status
unassessed
randomized Controlled Trial
Not recorded
blinding
not-confirmed
peer Reviewed
false
basis
Publication-specific design or publication status remains unconfirmed.
sources

https://www.sciencedirect.com/science/article/abs/pii/S0022395605001214 · https://www.researchgate.net/profile/Tao-Tan-8/publication/294122627_10-Hz_Repetitive_Transcranial_Magnetic_Stimulation_of_the_Left_Dorsolateral_Prefrontal_Cortex_Reduces_Heroin_Cue_Craving_in_Long-Term_Addicts/links/5a974d15aca27214056b3d1c/10-Hz-Repetitive-Transcranial-Magnetic-Stimulation-of-the-Left-Dorsolateral-Prefrontal-Cortex-Reduces-Heroin-Cue-Craving-in-Long-Term-Addicts.pdf

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
jadad
status
unassessed
score
Not recorded
evidence
Not recorded
Topics and recorded topic scores
  1. key
    sound:iii
    title
    7.83 Hz and low-frequency electromagnetic research
    collection
    sound
    trust Score
    2
  2. key
    general:sound-iii
    title
    7.83 Hz and low-frequency electromagnetic research
    collection
    general
    trust Score
    2
Citation snapshot and identifiers
id
src-c64e6046b78d
doi
10.1016/j.jpsychires.2005.09.001
pmid
Not recorded
citation Snapshot
Not recorded
citations By Collection
sound
Not recorded
general
Not recorded
Complete approved library record
id
src-c64e6046b78d
publication Key
Not recorded
aliases
None recorded
title
Striatal dopamine release after prefrontal repetitive transcranial magnetic stimulation in major depression: Preliminary results of a dynamic [123I] IBZM SPECT study
journal
Journal of Psychiatric Research
neurotransmitters
None recorded
year
Not recorded
authors
design
kind
Source record
identity Conflict
Not recorded
doi
10.1016/j.jpsychires.2005.09.001
urls

https://doi.org/10.1016/j.jpsychires.2005.09.001

collections

sound · general

categories

Molecular biomarkers · Brain & nervous system · Clinical & self-report

targets

DRD2

priority
1
quotes

“Five patients with a major depressive episode (DSM-IV) underwent an acute 10 Hz rTMS challenge with 3000 stimuli over the left dorsolateral prefrontal cortex during an IBZM-SPECT bolus and constant infusion protocol. · Data of nine SPECT investigations showed a significant reduction by 9.6 ± 6.2% in IBZM binding to striatal dopamine D2 receptors after rTMS challenge compared to baseline. · The reduction of IBZM binding observed after rTMS challenge is suggestive of a release in endogenous dopamine induced by prefrontal rTMS.” · “dopamine modulates addiction”

summary
limitation
citation Count
Not recorded
paper Trust Assessment
score
Not recorded
scope
Paper
status
unassessed
randomized Controlled Trial
Not recorded
blinding
not-confirmed
peer Reviewed
false
basis
Publication-specific design or publication status remains unconfirmed.
sources

https://www.sciencedirect.com/science/article/abs/pii/S0022395605001214 · https://www.researchgate.net/profile/Tao-Tan-8/publication/294122627_10-Hz_Repetitive_Transcranial_Magnetic_Stimulation_of_the_Left_Dorsolateral_Prefrontal_Cortex_Reduces_Heroin_Cue_Craving_in_Long-Term_Addicts/links/5a974d15aca27214056b3d1c/10-Hz-Repetitive-Transcranial-Magnetic-Stimulation-of-the-Left-Dorsolateral-Prefrontal-Cortex-Reduces-Heroin-Cue-Craving-in-Long-Term-Addicts.pdf

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
citations By Collection
sound
Not recorded
general
Not recorded
topics
  1. key
    sound:iii
    title
    7.83 Hz and low-frequency electromagnetic research
    collection
    sound
    trust Score
    2
  2. key
    general:sound-iii
    title
    7.83 Hz and low-frequency electromagnetic research
    collection
    general
    trust Score
    2
journal Key
journalofpsychiatricresearch
journal Label
Journal of Psychiatric Research
chapter Entries
  1. id
    iii-src-c64e6046b78d
    record Id
    src-c64e6046b78d
    title
    Striatal dopamine release after prefrontal repetitive transcranial magnetic stimulation in major depression: Preliminary results of a dynamic [123I] IBZM SPECT study
    journal
    Journal of Psychiatric Research
    year
    Not recorded
    authors
    design
    urls

    https://doi.org/10.1016/j.jpsychires.2005.09.001

    quotes
      1. text
        “Five patients with a major depressive episode (DSM-IV) underwent an acute
        emphasis
        false
      2. text
        10 Hz
        emphasis
        true
      3. text
        rTMS challenge with 3000 stimuli over the left dorsolateral prefrontal cortex during an IBZM-SPECT bolus and constant infusion protocol.
        emphasis
        false
      1. text
        Data of nine SPECT investigations showed a significant reduction by 9.6 ± 6.2% in IBZM
        emphasis
        false
      2. text
        binding to
        emphasis
        true
      3. text
        striatal
        emphasis
        false
      4. text
        dopamine D2 receptors
        emphasis
        true
      5. text
        after rTMS challenge compared to baseline.
        emphasis
        false
      1. text
        The reduction of IBZM binding observed after rTMS challenge is suggestive of a
        emphasis
        false
      2. text
        release
        emphasis
        true
      3. text
        in
        emphasis
        false
      4. text
        endogenous dopamine
        emphasis
        true
      5. text
        induced by prefrontal rTMS.”
        emphasis
        false
      1. text
        “dopamine modulates addiction”
        emphasis
        false
    citation Count
    Not recorded
    source Pages

    19 · 20

    targets

    DRD2

    categories

    Molecular biomarkers · Brain & nervous system · Clinical & self-report

    doi
    10.1016/j.jpsychires.2005.09.001
    pmid
    Not recorded
    paper Trust Assessment
    score
    Not recorded
    scope
    Paper
    status
    unassessed
    randomized Controlled Trial
    Not recorded
    blinding
    not-confirmed
    peer Reviewed
    false
    basis
    Publication-specific design or publication status remains unconfirmed.
    sources

    https://www.sciencedirect.com/science/article/abs/pii/S0022395605001214 · https://www.researchgate.net/profile/Tao-Tan-8/publication/294122627_10-Hz_Repetitive_Transcranial_Magnetic_Stimulation_of_the_Left_Dorsolateral_Prefrontal_Cortex_Reduces_Heroin_Cue_Craving_in_Long-Term_Addicts/links/5a974d15aca27214056b3d1c/10-Hz-Repetitive-Transcranial-Magnetic-Stimulation-of-the-Left-Dorsolateral-Prefrontal-Cortex-Reduces-Heroin-Cue-Craving-in-Long-Term-Addicts.pdf

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    collection
    sound
    chapter Number
    1
    topic Id
    iii
    topic Title
    7.83 Hz and low-frequency electromagnetic research
    trust Score
    2
  2. id
    general-iii-src-c64e6046b78d
    record Id
    src-c64e6046b78d
    title
    Striatal dopamine release after prefrontal repetitive transcranial magnetic stimulation in major depression: Preliminary results of a dynamic [123I] IBZM SPECT study
    journal
    Journal of Psychiatric Research
    year
    Not recorded
    authors
    design
    urls

    https://doi.org/10.1016/j.jpsychires.2005.09.001

    quotes
      1. text
        “Five patients with a major depressive episode (DSM-IV) underwent an acute
        emphasis
        false
      2. text
        10 Hz
        emphasis
        true
      3. text
        rTMS challenge with 3000 stimuli over the left dorsolateral prefrontal cortex during an IBZM-SPECT bolus and constant infusion protocol.
        emphasis
        false
      1. text
        Data of nine SPECT investigations showed a significant reduction by 9.6 ± 6.2% in IBZM
        emphasis
        false
      2. text
        binding to
        emphasis
        true
      3. text
        striatal
        emphasis
        false
      4. text
        dopamine D2 receptors
        emphasis
        true
      5. text
        after rTMS challenge compared to baseline.
        emphasis
        false
      1. text
        The reduction of IBZM binding observed after rTMS challenge is suggestive of a
        emphasis
        false
      2. text
        release
        emphasis
        true
      3. text
        in
        emphasis
        false
      4. text
        endogenous dopamine
        emphasis
        true
      5. text
        induced by prefrontal rTMS.”
        emphasis
        false
      1. text
        “dopamine modulates addiction”
        emphasis
        false
    citation Count
    Not recorded
    source Pages

    19 · 20

    targets

    DRD2

    categories

    Molecular biomarkers · Brain & nervous system · Clinical & self-report

    doi
    10.1016/j.jpsychires.2005.09.001
    pmid
    Not recorded
    paper Trust Assessment
    score
    Not recorded
    scope
    Paper
    status
    unassessed
    randomized Controlled Trial
    Not recorded
    blinding
    not-confirmed
    peer Reviewed
    false
    basis
    Publication-specific design or publication status remains unconfirmed.
    sources

    https://www.sciencedirect.com/science/article/abs/pii/S0022395605001214 · https://www.researchgate.net/profile/Tao-Tan-8/publication/294122627_10-Hz_Repetitive_Transcranial_Magnetic_Stimulation_of_the_Left_Dorsolateral_Prefrontal_Cortex_Reduces_Heroin_Cue_Craving_in_Long-Term_Addicts/links/5a974d15aca27214056b3d1c/10-Hz-Repetitive-Transcranial-Magnetic-Stimulation-of-the-Left-Dorsolateral-Prefrontal-Cortex-Reduces-Heroin-Cue-Craving-in-Long-Term-Addicts.pdf

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    collection
    general
    chapter Number
    2
    topic Id
    sound-iii
    topic Title
    7.83 Hz and low-frequency electromagnetic research
    trust Score
    2
jadad
status
unassessed
score
Not recorded
condition Evidence
  1. id
    depression
    evidence
    1. field
      title
      text
      Striatal dopamine release after prefrontal repetitive transcranial magnetic stimulation in major depression: Preliminary results of a dynamic [123I] IBZM SPECT study
      matched Text
      depression
conditions

depression

topic Trust Scores

2

full Text
status
not-indexed
retrieval Available
false

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