Effects of intranasal oxytocin administration on empathy and approach motivation in women with borderline personality disorder: a randomized controlled trial
Translational Psychiatry · randomised controlled trial
Original publication · Original publication
Attributed extracts from the research record
“The present study demonstrates for the first time that a single dose of OT given intranasally improves affective empathy and approach motivation in women with BPD.”
Evidence and provenance
Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.
Study design and assessment
- design
- randomised controlled trial
- assessment
- Not recorded
- trust Factor
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- false
- basis
- Randomized controlled design recorded in the publication-specific design or bibliographic indexing.
- sources
https://www.nature.com/articles/s41398-019-0658-4
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- jadad
- status
- unassessed
- score
- Not recorded
- evidence
- Not recorded
Topics and recorded topic scores
- key
- sound:xxxi
- title
- Oxytocin, empathy and intergroup relationships
- collection
- sound
- trust Score
- 3
- key
- general:sound-xxxi
- title
- Oxytocin, empathy and intergroup relationships
- collection
- general
- trust Score
- 3
Citation snapshot and identifiers
- id
- src-ebacdf327973
- doi
- 10.1038/s41398-019-0658-4
- pmid
- Not recorded
- citation Snapshot
- Not recorded
- citations By Collection
- sound
- 10
- general
- 10
Complete approved library record
- id
- src-ebacdf327973
- publication Key
- Not recorded
- aliases
- None recorded
- title
- Effects of intranasal oxytocin administration on empathy and approach motivation in women with borderline personality disorder: a randomized controlled trial
- journal
- Translational Psychiatry
- publisher Family
- nature
- publisher Family Label
- Nature Portfolio
- neurotransmitters
- None recorded
- year
- Not recorded
- authors
- design
- randomised controlled trial
- kind
- Source record
- identity Conflict
- Not recorded
- doi
- 10.1038/s41398-019-0658-4
- urls
https://www.nature.com/articles/s41398-019-0658-4 · https://doi.org/10.1038/s41398-019-0658-4
- collections
sound · general
- categories
Molecular biomarkers
- targets
OXT
- priority
- 1
- quotes
“The present study demonstrates for the first time that a single dose of OT given intranasally improves affective empathy and approach motivation in women with BPD.”
- summary
- limitation
- citation Count
- 10
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- false
- basis
- Randomized controlled design recorded in the publication-specific design or bibliographic indexing.
- sources
https://www.nature.com/articles/s41398-019-0658-4
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- citations By Collection
- sound
- 10
- general
- 10
- topics
- key
- sound:xxxi
- title
- Oxytocin, empathy and intergroup relationships
- collection
- sound
- trust Score
- 3
- key
- general:sound-xxxi
- title
- Oxytocin, empathy and intergroup relationships
- collection
- general
- trust Score
- 3
- journal Key
- translationalpsychiatry
- journal Label
- Translational Psychiatry
- chapter Entries
- id
- xxxi-src-ebacdf327973
- record Id
- src-ebacdf327973
- title
- Effects of intranasal oxytocin administration on empathy and approach motivation in women with borderline personality disorder: a randomized controlled trial
- journal
- Translational Psychiatry
- year
- Not recorded
- authors
- design
- randomised controlled trial
- urls
https://www.nature.com/articles/s41398-019-0658-4 · https://doi.org/10.1038/s41398-019-0658-4
- quotes
- text
- “The present study demonstrates for the first time that a single dose of OT given intranasally improves affective empathy and approach motivation in women with BPD.”
- emphasis
- false
- citation Count
- 10
- source Pages
127
- targets
OXT
- categories
Molecular biomarkers
- doi
- 10.1038/s41398-019-0658-4
- pmid
- Not recorded
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- false
- basis
- Randomized controlled design recorded in the publication-specific design or bibliographic indexing.
- sources
https://www.nature.com/articles/s41398-019-0658-4
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- collection
- sound
- chapter Number
- 6
- topic Id
- xxxi
- topic Title
- Oxytocin, empathy and intergroup relationships
- trust Score
- 3
- id
- general-xxxi-src-ebacdf327973
- record Id
- src-ebacdf327973
- title
- Effects of intranasal oxytocin administration on empathy and approach motivation in women with borderline personality disorder: a randomized controlled trial
- journal
- Translational Psychiatry
- year
- Not recorded
- authors
- design
- randomised controlled trial
- urls
https://www.nature.com/articles/s41398-019-0658-4 · https://doi.org/10.1038/s41398-019-0658-4
- quotes
- text
- “The present study demonstrates for the first time that a single dose of OT given intranasally improves affective empathy and approach motivation in women with BPD.”
- emphasis
- false
- citation Count
- 10
- source Pages
127
- targets
OXT
- categories
Molecular biomarkers
- doi
- 10.1038/s41398-019-0658-4
- pmid
- Not recorded
- paper Trust Assessment
- score
- 2
- scope
- Paper
- status
- assessed
- randomized Controlled Trial
- true
- blinding
- not-confirmed
- peer Reviewed
- false
- basis
- Randomized controlled design recorded in the publication-specific design or bibliographic indexing.
- sources
https://www.nature.com/articles/s41398-019-0658-4
- review Scope
- Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
- assessed At
- 2026-10-27
- collection
- general
- chapter Number
- 1
- topic Id
- sound-xxxi
- topic Title
- Oxytocin, empathy and intergroup relationships
- trust Score
- 3
- jadad
- status
- unassessed
- score
- Not recorded
- condition Evidence
- None recorded
- conditions
- None recorded
- topic Trust Scores
3
- full Text
- status
- open-license
- retrieval Available
- true
- url
- https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6892895/fullTextXML
- pmcid
- PMC6892895
- rights
- license
- http://creativecommons.org/licenses/by/4.0/
- statement
© The Author(s) 2019 https://creativecommons.org/licenses/by/4.0/ Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ .
- sha256
- 079513ce9df0162198dd0c5d663b890a081323b5c7496dce8174374b00841f12
- checked At
- 2026-10-24