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Oxytocin modulates dopamine-mediated reward in the rat subthalamic nucleus

Hormones and Behavior

Original publication

Attributed extracts from the research record

“The neuropeptide oxytocin acts within the STh to reduce the rewarding effects of the psychostimulant methamphetamine, through a proposed interaction with dopamine.”
“Preference to dopamine treatment was blocked by the activation of local oxytocin receptors.”
“These data suggest that dopamine neurotransmission in the STh produces rewarding effects that can be reduced by activation of local oxytocin receptors.”

Evidence and provenance

Chapter Trust Factor uses a minimum of three distinct qualifying studies. Publication records retain their own evidence and assessment.

Study design and assessment
design
assessment
Not recorded
trust Factor
score
Not recorded
scope
Paper
status
unassessed
randomized Controlled Trial
Not recorded
blinding
not-confirmed
peer Reviewed
false
basis
Publication-specific design or publication status remains unconfirmed.
sources

https://www.sciencedirect.com/science/article/abs/pii/S0018506X12002930

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
jadad
status
unassessed
score
Not recorded
evidence
Not recorded
Topics and recorded topic scores
  1. key
    sound:xxix
    title
    Oxytocin pathways, dopamine and serotonin
    collection
    sound
    trust Score
    1
  2. key
    general:sound-xxix
    title
    Oxytocin pathways, dopamine and serotonin
    collection
    general
    trust Score
    1
Citation snapshot and identifiers
id
src-ed35d20b36c4
doi
10.1016/j.yhbeh.2012.12.003
pmid
Not recorded
citation Snapshot
Not recorded
citations By Collection
sound
44
general
44
Complete approved library record
id
src-ed35d20b36c4
publication Key
Not recorded
aliases
None recorded
title
Oxytocin modulates dopamine-mediated reward in the rat subthalamic nucleus
journal
Hormones and Behavior
neurotransmitters
None recorded
year
Not recorded
authors
design
kind
Source record
identity Conflict
Not recorded
doi
10.1016/j.yhbeh.2012.12.003
urls

https://doi.org/10.1016/j.yhbeh.2012.12.003

collections

sound · general

categories

Molecular biomarkers

targets

OXTR · OXT

priority
1
quotes

“The neuropeptide oxytocin acts within the STh to reduce the rewarding effects of the psychostimulant methamphetamine, through a proposed interaction with dopamine.” · “Preference to dopamine treatment was blocked by the activation of local oxytocin receptors.” · “These data suggest that dopamine neurotransmission in the STh produces rewarding effects that can be reduced by activation of local oxytocin receptors.”

summary
limitation
citation Count
44
paper Trust Assessment
score
Not recorded
scope
Paper
status
unassessed
randomized Controlled Trial
Not recorded
blinding
not-confirmed
peer Reviewed
false
basis
Publication-specific design or publication status remains unconfirmed.
sources

https://www.sciencedirect.com/science/article/abs/pii/S0018506X12002930

review Scope
Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
assessed At
2026-10-27
citations By Collection
sound
44
general
44
topics
  1. key
    sound:xxix
    title
    Oxytocin pathways, dopamine and serotonin
    collection
    sound
    trust Score
    1
  2. key
    general:sound-xxix
    title
    Oxytocin pathways, dopamine and serotonin
    collection
    general
    trust Score
    1
journal Key
hormonesandbehavior
journal Label
Hormones and Behavior
chapter Entries
  1. id
    xxix-src-ed35d20b36c4
    record Id
    src-ed35d20b36c4
    title
    Oxytocin modulates dopamine-mediated reward in the rat subthalamic nucleus
    journal
    Hormones and Behavior
    year
    Not recorded
    authors
    design
    urls

    https://doi.org/10.1016/j.yhbeh.2012.12.003

    quotes
      1. text
        “The neuropeptide oxytocin acts within the STh to reduce the rewarding effects of the psychostimulant methamphetamine, through a proposed interaction with dopamine.”
        emphasis
        false
      1. text
        “Preference to dopamine treatment was blocked by the activation of local oxytocin receptors.”
        emphasis
        false
      1. text
        “These data suggest that dopamine neurotransmission in the STh produces rewarding effects that can be reduced by activation of local oxytocin receptors.”
        emphasis
        false
    citation Count
    44
    source Pages

    116

    targets

    OXTR · OXT

    categories

    Molecular biomarkers

    doi
    10.1016/j.yhbeh.2012.12.003
    pmid
    Not recorded
    paper Trust Assessment
    score
    Not recorded
    scope
    Paper
    status
    unassessed
    randomized Controlled Trial
    Not recorded
    blinding
    not-confirmed
    peer Reviewed
    false
    basis
    Publication-specific design or publication status remains unconfirmed.
    sources

    https://www.sciencedirect.com/science/article/abs/pii/S0018506X12002930

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    collection
    sound
    chapter Number
    6
    topic Id
    xxix
    topic Title
    Oxytocin pathways, dopamine and serotonin
    trust Score
    1
  2. id
    general-xxix-src-ed35d20b36c4
    record Id
    src-ed35d20b36c4
    title
    Oxytocin modulates dopamine-mediated reward in the rat subthalamic nucleus
    journal
    Hormones and Behavior
    year
    Not recorded
    authors
    design
    urls

    https://doi.org/10.1016/j.yhbeh.2012.12.003

    quotes
      1. text
        “The neuropeptide oxytocin acts within the STh to reduce the rewarding effects of the psychostimulant methamphetamine, through a proposed interaction with dopamine.”
        emphasis
        false
      1. text
        “Preference to dopamine treatment was blocked by the activation of local oxytocin receptors.”
        emphasis
        false
      1. text
        “These data suggest that dopamine neurotransmission in the STh produces rewarding effects that can be reduced by activation of local oxytocin receptors.”
        emphasis
        false
    citation Count
    44
    source Pages

    116

    targets

    OXTR · OXT

    categories

    Molecular biomarkers

    doi
    10.1016/j.yhbeh.2012.12.003
    pmid
    Not recorded
    paper Trust Assessment
    score
    Not recorded
    scope
    Paper
    status
    unassessed
    randomized Controlled Trial
    Not recorded
    blinding
    not-confirmed
    peer Reviewed
    false
    basis
    Publication-specific design or publication status remains unconfirmed.
    sources

    https://www.sciencedirect.com/science/article/abs/pii/S0018506X12002930

    review Scope
    Existing publication-specific assessments and bibliographic indexing; no blanket full-text appraisal.
    assessed At
    2026-10-27
    collection
    general
    chapter Number
    1
    topic Id
    sound-xxix
    topic Title
    Oxytocin pathways, dopamine and serotonin
    trust Score
    1
jadad
status
unassessed
score
Not recorded
condition Evidence
None recorded
conditions
None recorded
topic Trust Scores

1

full Text
status
not-indexed
retrieval Available
false

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